公开(公告)号：EP3505255A1

公开(公告)日：2019-07-03

申请号：EP18248268.7

申请日：2018-12-28

Applicant: STMicroelectronics S.r.l.

Inventor： CEREDA, Marco ,  RAIA, Lillo ,  BRAMANTI, Alessandro Paolo

IPC: B01L3/00 ,  B01L9/00 ,  B29C43/02 ,  B29C43/18

Abstract: A solid reagent containment unit is formed by a support (351; 366; 48); a frame body (352) fixed to the support and delimiting internally, together with the support, an analysis volume (354); a reagent-adhesion structure (356; 375) within the analysis volume; and at least one reagent cavity (359), which extends within the reagent-adhesion structure. The reagent-adhesion structure (356; 375) is of an adhesion material embossable at temperatures lower by 6-8°C than its own melting point and has a melting point such as not to interfere with the analysis. The reagent cavity (359) forms a retention wall, laterally surrounding the reagent cavity (359), and houses dried reagents (361). The adhesion material is chosen among wax, such as paraffin, a polymer, such as polycaprolactone, a solid fat, such as cocoa butter, and a gel, such as hydrogel or organogel.

公开(公告)号：EP3505256A1

公开(公告)日：2019-07-03

申请号：EP18248270.3

申请日：2018-12-28

Applicant: STMicroelectronics S.r.l.

Inventor： BIANCHESSI, Marco Angelo ,  RAIA, Lillo

IPC: B01L3/00 ,  C12Q1/6837 ,  G01N1/34

Abstract: A microfluidic group comprising a female connector (223) and a male needle connector (222). The female connector has a connector chamber (236) in a containment body (235); a duct (244) extending in the containment body (235) to a duct opening (244A) on a first face (236A) of the connector chamber (236); a needle entry hole (242) extending from a lateral face (235A) of the containment body (235) to a second face (236B), not facing the first face (236A) of the connector chamber (236); and a gasket (240) arranged in the connector chamber (236). The gasket has a side wall (243A) internally delimiting a cavity (245) and extending in part adjacent to the second face (235B) of the connector chamber (236). The cavity (245) of the gasket (240) faces the first face (236A) of the connector chamber (236) .

公开(公告)号：EP3505254A1

公开(公告)日：2019-07-03

申请号：EP18248262.0

申请日：2018-12-28

Applicant: STMicroelectronics S.r.l.

Inventor： CUCCHI, Davide ,  BIANCHESSI, Marco Angelo ,  COCCI, Alessandro ,  RAIA, Lillo ,  BRUNO, Lorenzo ,  SERINA, Nadia ,  CEREDA, Marco ,  PIROLA, Danilo ,  FERRARI, Pietro ,  FERRARA, Francesco ,  BRAMANTI, Alessandro Paolo

IPC: B01L3/00 ,  C12Q1/6837 ,  G01N1/34

Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening on a top face, and a fluidic inlet and a fluidic outlet on a bottom face. The cartridge houses an extraction chamber extending vertically from the sample inlet opening towards the bottom face and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber, near the bottom face, and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.

公开(公告)号：EP4173715A1

公开(公告)日：2023-05-03

申请号：EP22199518.6

申请日：2022-10-04

Applicant: STMicroelectronics S.r.l.

Inventor： RAIA, Lillo ,  FREGUGLIA, Alessandro ,  PESATURO, Massimiliano

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/68

Abstract: A chip (1) for biochemical reactions comprising: a first body (3) including a plurality of first through openings (5) arranged according to an arrangement pattern; a second body (4), having a hydrophilic surface (8), coupled to the first body (3) on the hydrophilic surface (8); and an intermediate layer (10), which extends over the hydrophilic surface (8) and forms a coupling interface between the first and the second bodies. The intermediate layer (10) is of hydrophobic material, extends continuously over the hydrophilic surface, and has a plurality of second through openings (12) through which respective regions (8') of the hydrophilic surface (8) are exposed. The hydrophilic regions (8') may be functionalized for carrying out a PCR.

公开(公告)号：EP3505073A1

公开(公告)日：2019-07-03

申请号：EP18248261.2

申请日：2018-12-28

Applicant: STMicroelectronics S.r.l.

Inventor： CEREDA, Marco ,  RAIA, Lillo ,  PIROLA, Danilo

IPC: A61B10/00 ,  C12Q1/6837 ,  A61B5/15 ,  B01L9/00 ,  B01L3/00 ,  G01N1/34 ,  B01F13/00 ,  B01F13/08

Abstract: An analysis unit (390) formed by an analysis body (394) housing an analysis chamber (392) and having a sample inlet (391B) and a supply channel (393) configured to fluidically connect the sample inlet to the analysis chamber (392). Dried assay reagents (395) are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilised mass formed by excipients and by assay-specific reagents.