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公开(公告)号：EP0292000A1
公开(公告)日：1988-11-23
申请号：EP88108127.7
申请日：1988-05-20
CPC分类号： A61K38/16 , A61K9/127 , A61K9/1271 , Y10S514/885 , Y10S530/825 , Y10S530/826 , Y10S530/827 , Y10S530/828 , Y10S530/829 , Y10S530/83
摘要： Use of a toxin which specifically inhibits cellular protein synthesis for the manufacture of a pharmaceutical composition for the treatment of acquired immunodeficiency syndrome (AIDS). The pharmaceutical composition comprises a liposomal preparation containing said toxin.
摘要翻译： 使用特异性抑制细胞蛋白质合成用于制备用于治疗获得性免疫缺陷综合征（AIDS）的药物组合物的毒素。 药物组合物包含含有所述毒素的脂质体制剂。
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公开(公告)号：EP0292000B1
公开(公告)日：1992-09-16
申请号：EP88108127.7
申请日：1988-05-20
CPC分类号： A61K38/16 , A61K9/127 , A61K9/1271 , Y10S514/885 , Y10S530/825 , Y10S530/826 , Y10S530/827 , Y10S530/828 , Y10S530/829 , Y10S530/83
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公开(公告)号：EP0432693A1
公开(公告)日：1991-06-19
申请号：EP90123694.3
申请日：1990-12-10
发明人： Kumagai, Kazuo , Nabeshima, Shigeyasu , Ohki, Koji , Ohmura, Kazutaka , Ikuta, Kazuyoshi , Kato, Shiro
IPC分类号： A61K9/127 , A61K31/685 , A61K37/02 , A61K39/00 , A61K39/385 , A61K47/48 , A61K35/14
CPC分类号： A61K9/1271 , A61K9/127 , A61K47/544
摘要： Liposomes cytotoxic to virus-infected cells which comprises as membrane constituents a phosphatidylcholine having phase-transition temperature of below 37°C, an acidic phospholipid, and cholesterol. Similar liposomes which additionally comprise a phospholipid linked to a peptide possessing anti-HIV activity, said peptide comprising an amino acid sequence:
Asn-Phe-Pro-Leu-Ile-Ile-Lys-Asn-Leu-Lys-Ile-
Glu-Asp-Ser-Asp-Thr-Tyr-Ile-Cys-Glu-Val-Glu-
Asp-Gln-Lys-Glu-Glu
wherein the Cys residue is L-cysteine, or S -benzylated or S -acetamidomethylated derivative of L-cysteine.摘要翻译： 对病毒感染细胞具有细胞毒性的脂质体，其包含具有低于37℃的相转变温度的磷脂酰胆碱的膜组分，酸性磷脂和胆固醇。 相似的脂质体，其另外包含与具有抗HIV活性的肽连接的磷脂，所述肽包含氨基酸序列：Asn-Phe-Pro-Leu-Ile-Lys-Asn-Leu-Lys-Ile-Glu-Asp -Ser-Asp-Thr-Tyr-Ile-Cys-Glu-Val-Glu-Asp-Gln-Lys-Glu-Glu其中Cys残基是L-半胱氨酸，或L-半胱氨酸S-苄基化或S-乙酰氨基甲基化衍生物 。
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