公开(公告)号：EP0721944A1

公开(公告)日：1996-07-17

申请号：EP95926500.0

申请日：1995-07-26

申请人： SUNTORY LIMITED

发明人： FUKAMI, Harukazu ,  SUMIDA, Motoo ,  NIWATA, Shinjiro ,  KAKUTANI, Saki ,  SAITOH, Masayuki ,  SHIBATA, Hiroshi ,  KISO, Yoshinobu

IPC分类号： C07D233/80 ,  C07D233/86 ,  A61K31/415 ,  A61K31/495

CPC分类号： C07D401/04 ,  C07D233/80 ,  C07D233/86 ,  C07D403/04 ,  C07D405/12

摘要： The invention relates to an imidazolidine derivative represented by the following general formula (1):

wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C 1-4 alkyl groups, C 1-4 alkoxy groups, C 1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C 2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C 1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C 1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C 1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.

公开(公告)号：EP0795548A1

公开(公告)日：1997-09-17

申请号：EP96932039.9

申请日：1996-09-27

申请人： SUNTORY LIMITED

发明人： FUKAMI, Harukazu ,  ITO, Akiko ,  NIWATA, Shinjiro ,  KAKUTANI, Saki ,  SUMIDA, Motoo ,  KISO, Yoshinobu

IPC分类号： C07D239/96 ,  A61K31/505

CPC分类号： C07D401/06 ,  C07D239/96 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07F9/65128

摘要： A chymase inhibitor containing as its effective ingredient a quinazoline derivative, or a pharmaceutically acceptable salt thereof, having the formula (1):
and a pharmaceutical preparation for the prevention of cardiac and circulatory system diseases derived from abnormal exacerbation of Ang II production containing the same as its effective ingredient.

摘要翻译： 含有具有式（1）的喹唑啉衍生物或其药学上可接受的盐作为其有效成分的食糜酶抑制剂：＆lt; CHEM＆gt;和用于预防源自Ang II产生异常恶化的心脏和循环系统疾病的药物制剂 含有与其有效成分相同的物质。

公开(公告)号：EP0795548B1

公开(公告)日：2002-07-03

申请号：EP96932039.9

申请日：1996-09-27

申请人： SUNTORY LIMITED

发明人： FUKAMI, Harukazu ,  ITO, Akiko ,  NIWATA, Shinjiro ,  KAKUTANI, Saki ,  SUMIDA, Motoo ,  KISO, Yoshinobu

IPC分类号： C07D239/96 ,  A61K31/505 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/06 ,  C07D239/96 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07F9/65128

摘要： Quinazoline derivatives represented by general formula (1) or pharmacologically acceptable salts thereof, and chymase inhibitors and preventives/remedies for cardiac and circulatory diseases caused by abnormal overproduction of AngII, each containing the same as the active ingredient.

公开(公告)号：EP0721944B1

公开(公告)日：2001-01-17

申请号：EP95926500.0

申请日：1995-07-26

申请人： SUNTORY LIMITED

发明人： FUKAMI, Harukazu ,  SUMIDA, Motoo ,  NIWATA, Shinjiro ,  KAKUTANI, Saki ,  SAITOH, Masayuki ,  SHIBATA, Hiroshi ,  KISO, Yoshinobu

IPC分类号： C07D233/80 ,  C07D233/86 ,  A61K31/415 ,  A61K31/495 ,  C07D233/84 ,  C07D405/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/04

CPC分类号： C07D401/04 ,  C07D233/80 ,  C07D233/86 ,  C07D403/04 ,  C07D405/12

摘要： An imidazolidine derivative represented by general formula (1) and medicines containing the derivative as the active ingredient, representative examples of which include a chymase inhibitor and a preventive or remedy for cardiac and circulatory diseases caused by abnormal palpitation induced by angiotensin II, wherein A and B represent each an aromatic hydrocarbon group which may be substituted by one to three substituents selected from among halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylenedioxy, phenoxy, nitro, cyano, phenyl, C2-C5 alkanoylamino, carboxyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyloxy which may be esterified with C1-C4 alkyl or alkenyl, N-alkylpiperazinylcarbonyl, N-alkylpiperazinylcarbonylalkyl, N-alkyl-piperazinylcarbonylalkyloxy and morpholinocarbonyl; X represents sulfonyl or carbonyl; and Y represents oxygen or sulfur.