公开(公告)号：EP2007803A4

公开(公告)日：2009-12-09

申请号：EP07751151

申请日：2007-02-20

申请人： SYNAGEVA BIOPHARMA CORP ,  UNIV GEORGIA RES FOUND

发明人： IVARIE ROBERT D ,  LIU GUODONG ,  RAPP JEFFREY C ,  MORRIS JULIE A ,  HARVEY ALEX J

IPC分类号： C07K14/535

CPC分类号： C07K14/535

公开(公告)号：EP2076530A4

公开(公告)日：2010-04-07

申请号：EP07839423

申请日：2007-10-10

申请人： SYNAGEVA BIOPHARMA CORP ,  UNIV GEORGIA

发明人： IVARIE ROBERT D ,  LIU GUODONG ,  RAPP JEFFREY C ,  MORRIS JULIE A ,  HARVEY ALEX J

IPC分类号： C07K14/405

CPC分类号： C07K14/505

公开(公告)号：EP1592773A4

公开(公告)日：2007-08-15

申请号：EP04704892

申请日：2004-01-23

申请人： AVIGENICS INC ,  UNIV GEORGIA RES FOUND

发明人： IVARIE ROBERT D ,  HARVEY ALEX J ,  MORRIS JULIE A ,  LIU GUODONG ,  RAPP JEFFREY C

IPC分类号： C12N15/85 ,  C12N15/867 ,  C12N15/90 ,  A01K67/00 ,  A01K67/027 ,  C12N15/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A01K2227/30 ,  A01K2267/01 ,  C12N15/8509 ,  C12N15/902 ,  C12N2740/13043 ,  C12N2799/027 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/40 ,  C12N2830/90 ,  C12N2840/20 ,  C12N2840/203

摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.