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1.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权一种用于阿尔法1,6-岩藻糖转移基因表达的失活的方法和组合物
公开(公告)号：EP2527435A9
公开(公告)日：2013-09-04
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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2.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权用于灭活α1,6岩藻糖基转移酶（FUT8）基因表达的方法和组合物
公开(公告)号：EP2527435A3
公开(公告)日：2013-02-13
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或切割半结构域的融合蛋白来灭活FUT8基因的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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3.发明授权Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权一种用于阿尔法1,6-岩藻糖转移基因表达的失活的方法和组合物
公开(公告)号：EP2527435B1
公开(公告)日：2014-12-17
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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4.发明公开Targeted genomic modification with partially single-stranded donor molecules 审中-公开Gezielte Genommodifikation mit partielleinzelsträngigenDonatormolekülen
公开(公告)号：EP2660318A1
公开(公告)日：2013-11-06
申请号：EP13166487.2
申请日：2011-02-09
CPC分类号： C12N15/902 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/907
摘要： Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
摘要翻译： 本文公开了包含一个或多个感兴趣序列侧翼的单链互补区的供体分子。 包含这些分子的供体分子和/或组合物可用于将外源序列靶向整合到细胞基因组中的特定感兴趣区域的方法中。
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5.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权Verfahren und Zusammensetzung zur Deaktivierung der alpha-1-fucosyltransferase-genexpression
公开(公告)号：EP2527435A2
公开(公告)日：2012-11-28
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白来灭活FUT8基因的方法和组合物。 还提供编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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