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1.发明公开Compositions and methods for protein production 审中-公开Zusammensetzungen und Methoden zur Protein Herstellung
公开(公告)号：EP2292274A1
公开(公告)日：2011-03-09
申请号：EP10183733.4
申请日：2005-09-08
CPC分类号： A61K48/00 , C07K14/4702 , C07K14/4705 , C07K2319/09 , C07K2319/43 , C07K2319/71 , C07K2319/81 , C12N2830/002
摘要： Disclosed herein are methods and compositions for enhanced protein production and overexpression using engineered zinc finger proteins.
摘要翻译： 本文公开了使用工程化锌指蛋白质增强蛋白质生产和过表达的方法和组合物。
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2.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权一种用于阿尔法1,6-岩藻糖转移基因表达的失活的方法和组合物
公开(公告)号：EP2527435A9
公开(公告)日：2013-09-04
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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3.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权用于灭活α1,6岩藻糖基转移酶（FUT8）基因表达的方法和组合物
公开(公告)号：EP2527435A3
公开(公告)日：2013-02-13
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或切割半结构域的融合蛋白来灭活FUT8基因的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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公开(公告)号：EP2266396A2
公开(公告)日：2010-12-29
申请号：EP10179632.4
申请日：2002-09-24
CPC分类号： C12N15/85 , A61K35/12 , C07H21/04 , C12N5/0606 , C12N15/62 , C12N15/63 , C12N2501/40 , C12N2503/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
摘要： Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
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5.发明公开Methods and compositions for generation of BAX- and BAK-deficient cell lines 审中-公开用于产生BAX-和BAK-缺陷细胞系的方法和组合物
公开(公告)号：EP2910568A3
公开(公告)日：2015-09-09
申请号：EP15151636.6
申请日：2009-06-10
CPC分类号： C12N5/0018 , C07K2319/81 , C12N9/22 , C12N2501/48 , C12N2510/02
摘要： Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
摘要翻译： 本文公开了使用工程化核酸酶产生Bak-和/或Bax缺陷型细胞系的方法和组合物。
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6.发明授权Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权一种用于阿尔法1,6-岩藻糖转移基因表达的失活的方法和组合物
公开(公告)号：EP2527435B1
公开(公告)日：2014-12-17
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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7.发明公开Methods and compositions for generation of BAX- and BAK-deficient cell lines 审中-公开方法和组合物用于生产BAX和BAK缺陷细胞系的
公开(公告)号：EP2910568A2
公开(公告)日：2015-08-26
申请号：EP15151636.6
申请日：2009-06-10
CPC分类号： C12N5/0018 , C07K2319/81 , C12N9/22 , C12N2501/48 , C12N2510/02
摘要： Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
摘要翻译： 公开在用于生成Bak和/或使用工程核酸酶Bax蛋白缺陷细胞系的方法和组合物。
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8.发明公开Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression 有权Verfahren und Zusammensetzung zur Deaktivierung der alpha-1-fucosyltransferase-genexpression
公开(公告)号：EP2527435A2
公开(公告)日：2012-11-28
申请号：EP12172360.5
申请日：2008-07-10
CPC分类号： C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
摘要： Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白来灭活FUT8基因的方法和组合物。 还提供编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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公开(公告)号：EP2266396A3
公开(公告)日：2011-06-15
申请号：EP10179632.4
申请日：2002-09-24
CPC分类号： C12N15/85 , A61K35/12 , C07H21/04 , C12N5/0606 , C12N15/62 , C12N15/63 , C12N2501/40 , C12N2503/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
摘要： Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
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