公开(公告)号：EP2938358A2

公开(公告)日：2015-11-04

申请号：EP13821489.5

申请日：2013-12-26

申请人： SANOFI

发明人： BAUDAT, Yves ,  BLANCHE, Francis ,  CAMERON, Béatrice ,  DABDOUBI, Tarik ,  LEFEBVRE, Anne-Marie ,  MATHIEU, Magali ,  MERINO-TRIGO, Ana ,  NUNES, Manoel

IPC分类号： A61K39/395 ,  A61P35/00 ,  C12Q1/68 ,  C07K16/28 ,  A61K47/48

CPC分类号： C07K16/2896 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6863 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/574

摘要： Antibodies are provided which specifically bind human and Macaca fascicularis lysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as LAMP1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. The application further provides for the detection of LAMP1 gene amplification or gain in cancer cells leading to the determination if patients with cancer are likely to respond to anti-LAMP1 therapy. Anti-LAMP1 therapeutic agent for use for treating cancer in a patient harboring LAMP1 gene copy number gain in cancer cells is further provided.

摘要翻译： 提供了特异性结合人和食蟹猕猴（Macaca fascicularis）溶酶体相关膜蛋白1（LAMP1）蛋白的抗体和包含与生长抑制剂缀合或连接的所述抗体的免疫缀合物。 还提供了包含本发明的抗体或免疫缀合物的药物组合物以及抗体或免疫缀合物用于治疗癌症的用途，以及LAMP1抗体，包含编码所述抗体的序列的分离的核酸，载体和宿主细胞，以及所述 抗体作为诊断工具。 本申请还提供了检测癌细胞中的LAMP1基因扩增或增加，从而导致确定癌症患者是否可能对抗LAMP1疗法有反应。 因此，提出了选择癌症患者的体外方法，其包括在患有癌细胞的癌症患者的生物样品中确定所述患者携带LAMP1基因拷贝数增益; 并根据LAMP1基因拷贝数增益的存在选择患者。 进一步提供了用于治疗患有癌症细胞中LAMP1基因拷贝数增加的患者的癌症的抗LAMP1治疗剂。

公开(公告)号：EP3400961A1

公开(公告)日：2018-11-14

申请号：EP18175369.0

申请日：2013-12-26

申请人： Sanofi

发明人： BAUDAT, Yves ,  BLANCHE, Francis ,  CAMERON, Béatrice ,  DABDOUBI, Tarik ,  MATHIEU, Magali ,  MERINO-TRIGO, Ana ,  LEFEBVRE, Anne-Marie ,  NUNES, Manoel

IPC分类号： A61K39/395 ,  A61P35/00 ,  C12Q1/68 ,  C07K16/28 ,  A61K47/68

CPC分类号： C07K16/2896 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6863 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/574

摘要： Antibodies are provided which specifically bind human and Macaca fascicularis lysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as LAMP1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. The application further provides for the detection of LAMP1 gene amplification or gain in cancer cells leading to the determination if patients with cancer are likely to respond to anti-LAMP1 therapy. Therefore, it is proposed an in vitro method of selecting patients with cancer which comprises determining, in a biological sample of a patient with cancer which includes cancer cells, if said patient harbors a LAMP1 gene copy number gain; and selecting the patient based on the presence of LAMP1 gene copy number gain. Anti-LAMP1 therapeutic agent for use for treating cancer in a patient harboring LAMP1 gene copy number gain in cancer cells is further provided.