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公开(公告)号：EP3199552B1
公开(公告)日：2019-12-25
申请号：EP17157890.9
申请日：2013-11-20
申请人： SANOFI
发明人： BERNE, Pierre-François , BLANCHE, Francis , BOUCHARD, Hervé , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stéphanie , FERRARI, Paul , RAK, Alexey
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
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公开(公告)号：EP3594243A1
公开(公告)日：2020-01-15
申请号：EP19181036.5
申请日：2013-11-20
申请人： Sanofi
发明人： BERNE, Pierre-François , BLANCHE, Francis , BOUCHARD, Hervé , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stéphanie , FERRARI, Paul , RAK, Alexey
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
摘要： The present application discloses antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The application also discloses immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the disclosure. The antibodies or immunoconjugates described herein are used for the treatment of cancer or for diagnostic purposes.
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公开(公告)号：EP3400961A1
公开(公告)日：2018-11-14
申请号：EP18175369.0
申请日：2013-12-26
申请人： Sanofi
发明人： BAUDAT, Yves , BLANCHE, Francis , CAMERON, Béatrice , DABDOUBI, Tarik , MATHIEU, Magali , MERINO-TRIGO, Ana , LEFEBVRE, Anne-Marie , NUNES, Manoel
IPC分类号： A61K39/395 , A61P35/00 , C12Q1/68 , C07K16/28 , A61K47/68
CPC分类号： C07K16/2896 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/574
摘要： Antibodies are provided which specifically bind human and Macaca fascicularis lysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as LAMP1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. The application further provides for the detection of LAMP1 gene amplification or gain in cancer cells leading to the determination if patients with cancer are likely to respond to anti-LAMP1 therapy. Therefore, it is proposed an in vitro method of selecting patients with cancer which comprises determining, in a biological sample of a patient with cancer which includes cancer cells, if said patient harbors a LAMP1 gene copy number gain; and selecting the patient based on the presence of LAMP1 gene copy number gain. Anti-LAMP1 therapeutic agent for use for treating cancer in a patient harboring LAMP1 gene copy number gain in cancer cells is further provided.
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公开(公告)号：EP3199552A1
公开(公告)日：2017-08-02
申请号：EP17157890.9
申请日：2013-11-20
申请人： SANOFI
发明人： BERNE, Pierre-François , BLANCHE, Francis , BOUCHARD, Hervé , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stéphanie , FERRARI, Paul , RAK, Alexey
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
摘要： The present disclosure describes antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The disclosure also provides immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the disclosure . The antibodies or immunoconjugates of the disclosure are used for the treatment of cancer or for diagnostic purposes.
摘要翻译： 本公开描述了结合人和食蟹猴CEACAM5蛋白的抗体，以及包含编码所述抗体的序列的分离的核酸，载体和宿主细胞。 本公开还提供了包含与生长抑制剂缀合或连接的所述抗体的免疫缀合物，并且涉及包含抗体的药物组合物或本公开的免疫缀合物。 本公开的抗体或免疫偶联物用于治疗癌症或用于诊断目的。
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公开(公告)号：EP2922875B1
公开(公告)日：2017-03-15
申请号：EP13794894.9
申请日：2013-11-20
申请人： SANOFI
发明人： BERNE, Pierre-Francois , BLANCHE, Francis , BOUCHARD, Hervé , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stéphanie , FERRARI, Paul , RAK, Alexey
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
CPC分类号： C07K16/3007 , A61K31/537 , A61K47/6803 , A61K47/6849 , A61K47/6853 , C07K16/2896 , C07K16/464 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/57473 , G01N2333/70503
摘要： The present disclosure describes antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The disclosure also provides immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the disclosure . The antibodies or immunoconjugates of the disclosure are used for the treatment of cancer or for diagnostic purposes.
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公开(公告)号：EP2922875A1
公开(公告)日：2015-09-30
申请号：EP13794894.9
申请日：2013-11-20
申请人： SANOFI
发明人： BERNE, Pierre-Francois , BLANCHE, Francis , BOUCHARD, Hervé , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stéphanie , FERRARI, Paul , RAK, Alexey
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
CPC分类号： C07K16/3007 , A61K31/537 , A61K47/6803 , A61K47/6849 , A61K47/6853 , C07K16/2896 , C07K16/464 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/57473 , G01N2333/70503
摘要： The present disclosure describes antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The disclosure also provides immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the disclosure . The antibodies or immunoconjugates of the disclosure are used for the treatment of cancer or for diagnostic purposes.
摘要翻译： 本发明公开了结合人和猕猴属CEACAM5蛋白的抗体，以及包含编码所述抗体的序列的分离的核酸，载体和宿主细胞。 本发明还公开了包含与生长抑制剂缀合或连接的所述抗体的免疫缀合物，以及包含本发明的抗体或免疫缀合物的药物组合物。 本发明的抗体或免疫偶联物用于治疗癌症或用于诊断目的。
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">7.发明公开
公开(公告)号：EP2486058A1
公开(公告)日：2012-08-15
申请号：EP10771381.0
申请日：2010-10-08
申请人： SANOFI
发明人： HUBER, Jochen , BLANCHE, Francis , DABDOUBI, Tarik , SOUBRIER, Fabienne , FOCKEN, Ingo , KRUIP, Jochen , HEERMEIER, Katherin , LANGE, Christian
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/92
摘要： The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the "receptor for advanced glycation endproducts" (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against RAGE, a pharmaceutical composition comprising at least one polypeptide or nucleic as defined above, optionally for treating a RAGE-related disease or disorder and a method of diagnosing a RAGE-related disease or disorder.
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8.发明公开
公开(公告)号：EP2938358A2
公开(公告)日：2015-11-04
申请号：EP13821489.5
申请日：2013-12-26
申请人： SANOFI
发明人： BAUDAT, Yves , BLANCHE, Francis , CAMERON, Béatrice , DABDOUBI, Tarik , LEFEBVRE, Anne-Marie , MATHIEU, Magali , MERINO-TRIGO, Ana , NUNES, Manoel
IPC分类号： A61K39/395 , A61P35/00 , C12Q1/68 , C07K16/28 , A61K47/48
CPC分类号： C07K16/2896 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/574
摘要： Antibodies are provided which specifically bind human and Macaca fascicularis lysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as LAMP1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. The application further provides for the detection of LAMP1 gene amplification or gain in cancer cells leading to the determination if patients with cancer are likely to respond to anti-LAMP1 therapy. Anti-LAMP1 therapeutic agent for use for treating cancer in a patient harboring LAMP1 gene copy number gain in cancer cells is further provided.
摘要翻译： 提供了特异性结合人和食蟹猕猴（Macaca fascicularis）溶酶体相关膜蛋白1（LAMP1）蛋白的抗体和包含与生长抑制剂缀合或连接的所述抗体的免疫缀合物。 还提供了包含本发明的抗体或免疫缀合物的药物组合物以及抗体或免疫缀合物用于治疗癌症的用途，以及LAMP1抗体，包含编码所述抗体的序列的分离的核酸，载体和宿主细胞，以及所述 抗体作为诊断工具。 本申请还提供了检测癌细胞中的LAMP1基因扩增或增加，从而导致确定癌症患者是否可能对抗LAMP1疗法有反应。 因此，提出了选择癌症患者的体外方法，其包括在患有癌细胞的癌症患者的生物样品中确定所述患者携带LAMP1基因拷贝数增益; 并根据LAMP1基因拷贝数增益的存在选择患者。 进一步提供了用于治疗患有癌症细胞中LAMP1基因拷贝数增加的患者的癌症的抗LAMP1治疗剂。
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9.发明授权ANTICORPS HUMANISES SPÉCIFIQUES DE LA FORME PROTOFIBRILLAIRE DU PEPTIDE BÉTA-AMYLOIDE 有权FOR PROTOFIBRILLENFORMβ淀粉样肽特异性抗体
公开(公告)号：EP2430049B1
公开(公告)日：2015-04-15
申请号：EP10728743.5
申请日：2010-05-11
申请人： SANOFI
发明人： BAURIN, Nicolas , BLANCHE, Francis , CAMERON, Béatrice , DUCHESNE, Marc , MIKOL, Vincent , NAIMI, Souad , PRADIER, Laurent , SHI, Yi
IPC分类号： C07K16/18 , G01N33/68 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61K39/3955 , C07H21/04 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/92 , C12N15/63 , C12N2015/8518
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10.发明公开PROTÉINE DE FUSION ROBO1-FC ET SON UTILISATION DANS LE TRAITEMENT DES TUMEURS 审中-公开ROBO1-Fc融合蛋白及其用途，用于肿瘤的治疗
公开(公告)号：EP2558489A1
公开(公告)日：2013-02-20
申请号：EP11719346.6
申请日：2011-04-08
申请人： SANOFI
发明人： BLANCHE, Francis , CAMERON, Béatrice , DABDOUBI, Tarik , DOL-GLEIZES, Frédérique , FONS, Pierre , HERAULT, Jean-Pascal , PRADES, Catherine
IPC分类号： C07K14/475 , A61K38/00
CPC分类号： C07K14/475
摘要： The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant protein. Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.
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