公开(公告)号：EP4440610A1

公开(公告)日：2024-10-09

申请号：EP22831051.2

申请日：2022-11-29

申请人： Sanofi Pasteur, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： CHAN, Yvonne ,  SASMAL, Sukanya ,  STUEBLER, Antonia ,  KISHKO, Michael ,  MUNDLE, Sophia ,  ZHANG, Linong ,  DINAPOLI, Josh ,  ALAMARES-SAPUAY, Judith ,  ANOSOVA, Natalie ,  CHIVUKULA, Sudha ,  DANZ, Hillary ,  STRUGNELL, Tod ,  GROPPO, Rachel ,  COLLINS, Peter ,  BUCHHOLZ, Ursula ,  MUNIR, Shirin ,  DAHAL, Bibha

IPC分类号： A61K39/12 ,  A61K39/155 ,  A61P11/00 ,  A61P31/14 ,  C07K14/005

CPC分类号： A61K39/12 ,  A61K39/155 ,  A61P11/00 ,  A61P31/14 ,  C07K14/005 ,  C07K2319/0020130101 ,  C12N2760/1832220130101 ,  C12N2760/1833420130101 ,  A61K2039/525620130101 ,  C12N2760/1864120130101 ,  C12N2760/1864320130101

公开(公告)号：EP4161567A2

公开(公告)日：2023-04-12

申请号：EP21736442.1

申请日：2021-06-04

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： COLLINS, Peter ,  BUCHHOLZ, Ursula

IPC分类号： A61K39/12

公开(公告)号：EP3247388A1

公开(公告)日：2017-11-29

申请号：EP16702318.3

申请日：2016-01-20

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： COLLINS, Peter ,  LIANG, Bo ,  MUNIR, Shirin ,  NUTT, Anne, Schaap ,  BUCHHOLZ, Ursula ,  MACKOW, Natalie ,  KWONG, Peter ,  GRAHAM, Barney ,  MCLELLAN, Jason

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  C07K2319/03 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18641 ,  C12N2760/18734 ,  C12N2760/18741

摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.

公开(公告)号：EP4142785A2

公开(公告)日：2023-03-08

申请号：EP21726787.1

申请日：2021-04-29

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： KWONG, Peter ,  STEWART-JONES, Guillaume ,  GORMAN, Jason ,  OU, Li ,  ZHOU, Tongqing ,  ZHANG, Baoshan ,  KONG, Wing-Pui ,  TSYBOVSKY, Yaroslav ,  MASCOLA, John ,  COLLINS, Peter ,  BUCHHOLZ, Ursula

IPC分类号： A61K39/155 ,  A61K39/12 ,  A61P31/14