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公开(公告)号：EP3271389B1
公开(公告)日：2020-02-12
申请号：EP16716979.6
申请日：2016-03-18
发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi
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公开(公告)号：EP3189067A1
公开(公告)日：2017-07-12
申请号：EP15766697.5
申请日：2015-09-04
发明人： KWONG, Peter , PANCERA, Marie , ZHOU, Tongqing , GEORGIEV, Ivelin , JOYCE, Michael Gordon , ACHARYA, Priyamvada , GORMAN, Jason , YANG, Yongping , DRUZ, Aliaksandr , STEWART-JONES, Guillaume , CHEN, Rita , CHUANG, Gwo-Yu , CHENG, Cheng , BAXA, Ulrich , MASCOLA, John , LYNCH, Rebecca , ZHANG, Baoshan
CPC分类号： C07K14/435 , A61K39/12 , A61K39/21 , A61K2039/55555 , A61K2039/55561 , A61K2039/55577 , C07K14/005 , C07K16/1063 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.
摘要翻译： 公开了在融合前成熟闭合构象中稳定的HIV-1环境外三聚体及其使用和生产方法。 在几个实施方案中，HIV-1内源结构域三聚体和/或核酸分子可用于在受试者体内产生对HIV-1的免疫应答。 在另外的实施方案中，治疗有效量的HIV-1内源结构域三聚体可以在治疗或预防HIV-1感染的方法中施用于受试者。
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公开(公告)号：EP4214229A1
公开(公告)日：2023-07-26
申请号：EP21870173.8
申请日：2021-09-15
申请人： Duke University , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： SEMPOWSKI, Gregory , HAYNES, Barton F. , SAUNDERS, Kevin , LI, Dapeng , LU, Xiaozhi , EDWARDS, Robert J. , ACHARYA, Priyamvada , MANNE, Kartik , GOBEIL, Sophie , MASCOLA, John R. , GRAHAM, Barney S. , ZHOU, Tongqing
IPC分类号： C07K16/10
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公开(公告)号：EP2970398A1
公开(公告)日：2016-01-20
申请号：EP14775224.0
申请日：2014-03-13
发明人： BOYINGTON, Jeffrey , GEORGIEV, Ivelin, Stefanov , PANCERA, Marie , SOTO, Cinque , SRIVATSAN, Sanjay , STEWART-JONES, Guillaume , KWONG, Peter, D. , GRAHAM, Barney, S. , MCLELLAN, Jason, S. , JOYCE, Michael, Gordon , KANEKIYO, Masaru , ZHANG, Baoshan , CHEN, Lei , CHEN, Man , CHUANG, Gwo-Yu , GORMAN, Jason , YANG, Yongping , ZHOU, Tongqing , SASTRY, Mallika , OFEK, Gilad
IPC分类号： C07K14/135 , A61K39/00 , A61K39/155 , A61K38/10 , A61P43/00 , C12N15/45 , C12N15/62
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/543 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K2319/21 , C07K2319/22 , C07K2319/50 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N2710/10343 , C12N2760/18522 , C12N2760/18534 , G01N33/564
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
摘要翻译： 公开了呼吸道合胞病毒（RSV）抗原，包括以融合前构象稳定的重组RSV F蛋白。 还公开了编码抗原的核酸和生产抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是通过将治疗有效量的抗原给予受试者来治疗或预防受试者中的RSV感染的方法。
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公开(公告)号：EP4421177A2
公开(公告)日：2024-08-28
申请号：EP24174501.7
申请日：2014-03-13
发明人： BOYINGTON, Jeffrey , GEORGIEV, Ivelin, Stefanov , PANCERA, Marie , SOTO, Cinque , SRIVATSAN, Sanjay , STEWART-JONES, Guillaume , KWONG, Peter, D. , GRAHAM, Barney, S. , MCLELLAN, Jason, S. , JOYCE, Michael, Gordon , KANEKIYO, Masaru , ZHANG, Baoshan , CHEN, Lei , CHEN, Man , CHUANG, Gwo-Yu , GORMAN, Jason , YANG, Yongping , ZHOU, Tongqing , SASTRY, Mallika , OFEK, Gilad
IPC分类号： C12N15/62
CPC分类号： A61K39/155 , A61K2039/5320130101 , A61K2039/5556120130101 , A61K2039/5556620130101 , C12N2760/1853420130101 , A61K2039/525220130101 , A61K2039/525420130101 , A61K2039/54320130101 , A61K2039/5550520130101 , C12N2710/1034320130101 , A61K39/12 , C07K2319/2120130101 , C07K2319/2220130101 , C07K2319/5020130101 , C07K2319/7020130101 , C07K2319/73520130101 , C12N2760/1852220130101 , C07K14/005 , A61P31/14 , A61P43/00
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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公开(公告)号：EP4142785A2
公开(公告)日：2023-03-08
申请号：EP21726787.1
申请日：2021-04-29
发明人： KWONG, Peter , STEWART-JONES, Guillaume , GORMAN, Jason , OU, Li , ZHOU, Tongqing , ZHANG, Baoshan , KONG, Wing-Pui , TSYBOVSKY, Yaroslav , MASCOLA, John , COLLINS, Peter , BUCHHOLZ, Ursula
IPC分类号： A61K39/155 , A61K39/12 , A61P31/14
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公开(公告)号：EP3271389B8
公开(公告)日：2020-04-22
申请号：EP16716979.6
申请日：2016-03-18
发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi
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公开(公告)号：EP2480572B1
公开(公告)日：2019-01-30
申请号：EP10760878.8
申请日：2010-09-24
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , University of Washington through its Center for Commercialization
发明人： MASCOLA, John, R. , WYATT, Richard , WU, Xueling , LI, Yuxing , HOGERKORP, Carl-Magnus , ROEDERER, Mario , YANG, Zhi-yong , NABEL, Gary , KWONG, Peter , ZHOU, Tongqing , CONNORS, Mark , OFEK, Gilad , SHAPIRO, Lawrence , ZHU, Jiang , SCHIEF, William R.
IPC分类号： C07K16/10
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公开(公告)号：EP2828294A1
公开(公告)日：2015-01-28
申请号：EP13763664.3
申请日：2013-03-15
发明人： MASCOLA, John, R. , LYNCH, Rebecca, M. , WU, Xueling , CONNORS, Mark , ZHOU, Tongqing , CASAZZA, Joseph , KWONG, Peter, D.
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , A61K2039/545 , C07K2317/31 , C07K2317/76 , G01N33/56983
摘要： Neutralizing antibodies that specifically bind to HIV-1 gpl20 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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公开(公告)号：EP4291226A1
公开(公告)日：2023-12-20
申请号：EP22705961.5
申请日：2022-02-04
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