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公开(公告)号：EP3246400A1
公开(公告)日：2017-11-22
申请号：EP17178956.3
申请日：2013-01-09
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , B01D15/363 , C12N7/00 , C12N2710/16634 , C12N2710/16651 , C12N2710/16671
摘要： The present invention provides a composition comprising Herpes Simplex Virus (HSV) particles in a defined liquid stabilization buffer, which may further comprise a pharmaceutically acceptable carrier and/or an adjuvant; a pharmaceutically acceptable dosage form and use of the compositions for therapy are also provided.
摘要翻译： 本发明提供了一种组合物，其包含定义的液体稳定缓冲液中的单纯疱疹病毒（HSV）颗粒，其可以进一步包含药学上可接受的载体和/或佐剂; 还提供了药学上可接受的剂型和用于治疗的组合物的用途。
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公开(公告)号：EP2852662A2
公开(公告)日：2015-04-01
申请号：EP13793902.1
申请日：2013-05-21
发明人： ANDERSON, Stephen , DELAGRAVE, Simon , HAMBERGER, John , LI, Qinglian , MUNDLE, Sophia , RAHMAN, Nausheen
IPC分类号： C12N7/00
摘要： The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compositions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
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公开(公告)号：EP2802649B1
公开(公告)日：2017-08-09
申请号：EP13735764.6
申请日：2013-01-09
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , B01D15/363 , C12N7/00 , C12N2710/16634 , C12N2710/16651 , C12N2710/16671
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公开(公告)号：EP2852662B1
公开(公告)日：2020-09-16
申请号：EP13793902.1
申请日：2013-05-21
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5.发明授权
公开(公告)号：EP2310495B1
公开(公告)日：2017-11-22
申请号：EP09807164.0
申请日：2009-08-11
CPC分类号： C12N7/00 , C12N5/0018 , C12N2500/34 , C12N2500/36 , C12N2500/76 , C12N2710/16051 , C12N2710/16052
摘要： The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.
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公开(公告)号：EP2802649A1
公开(公告)日：2014-11-19
申请号：EP13735764.6
申请日：2013-01-09
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , B01D15/363 , C12N7/00 , C12N2710/16634 , C12N2710/16651 , C12N2710/16671
摘要： The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.
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