公开(公告)号：EP1991266A2

公开(公告)日：2008-11-19

申请号：EP07705530.9

申请日：2007-01-15

申请人： Pfizer Products Inc.

发明人： DOMINOWSKI, Paul, Joseph ,  MANNAN, Ramasamy, Mannar ,  MEDIRATTA, Sangita

IPC分类号： A61K39/39 ,  C07H15/12 ,  C07H13/12

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55572 ,  C07H13/12 ,  C07H15/12 ,  C12N2710/16051 ,  C12N2710/16734 ,  C12N2760/18351 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18651

摘要： This invention relates to compositions and methods of preparing stable adjuvant diluent stock solutions and final adjuvant solutions comprising glycolipids, weak acids, alcohols, nonionic surfactants and buffers.

公开(公告)号：EP2357224A4

公开(公告)日：2012-05-09

申请号：EP09826325

申请日：2009-09-22

申请人： REPULICAN GOVERNMENTAL ENTPR ON THE RIGHT OF ECONOMIC MAN RES INST FOR BIOLOG SAFETY PROBLEMS OF THE

发明人： SANDYBAYEV NURLAN TAMAMBAYEVICH ,  MAMADALIYEV SEIDIGAPBAR MAMADALIYEVICH ,  ZHOLDYBAYEVA YELENA VITAL YEVNA ,  SULTANKULOVA KULYAISAN TURLYBAYEVNA ,  STROCHKOV VITALIY MIKHAILOVICH ,  ZAITSEV VALENTIN LUK YANOVICH

IPC分类号： C12N7/00 ,  C12N15/34

CPC分类号： C12N15/1006 ,  C12N7/00 ,  C12N2710/16051

公开(公告)号：EP2267119A1

公开(公告)日：2010-12-29

申请号：EP09727365.0

申请日：2009-03-31

申请人： Japan Tobacco, Inc.

发明人： TAKAKURA, Yoshimitsu ,  ICHIKAWA, Masako ,  KONDO, Kazuhiro ,  SHIMIZU, Akihiro

IPC分类号： C12N7/02 ,  C12N15/09

CPC分类号： C12N15/1003 ,  C12N7/00 ,  C12N2710/16051 ,  G01N2333/36

摘要： The present invention provides a novel method that can increase readily a virus or viral vector concentration in a solution having a low concentration and a kit for performing the method. Conventional methods require complicated operations, expensive equipment, or highly trained experts for efficiently concentrating viruses from low-concentration virus solutions. The method of the present invention can concentrate viral vectors readily while maintaining infection abilities of the viral vectors, and thus it can be used as a safe and simple technique for concentrating a vector useful in the field of a genetic therapy or a vaccine therapy using a viral vector.

摘要翻译： 本发明提供了一种可以容易地增加具有低浓度的溶液中的病毒或病毒载体浓度的新方法和用于实施该方法的试剂盒。 常规方法需要复杂的操作，昂贵的设备或受过高度训练的专家，以有效地集中低浓度病毒解决方案的病毒。 本发明的方法可以容易地集中病毒载体，同时保持病毒载体的感染能力，因此可用作一种安全简单的技术，用于浓缩在遗传治疗领域中有用的载体或使用 病毒载体。

公开(公告)号：EP0016552B2

公开(公告)日：1988-01-13

申请号：EP80300546.1

申请日：1980-02-25

申请人： Kendrew Biosystems, Inc.

发明人： Widder, Kenneth, Jon ,  Senyei, Andrew Erwin

IPC分类号： C12N1/02 ,  C12N7/02 ,  C12Q1/00

CPC分类号： C12N7/00 ,  A61K35/12 ,  C12M47/04 ,  C12N1/02 ,  C12N2710/16051 ,  G01N33/5434 ,  G01N33/544 ,  G01N2333/31 ,  G01N2333/76 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84 ,  Y10S436/828

公开(公告)号：EP0804233B1

公开(公告)日：2001-10-10

申请号：EP94922473.7

申请日：1994-07-12

申请人： AMERICAN CYANAMID COMPANY

发明人： PETERSEN, Gary Ralph ,  WELNIAK, Ellan ,  VAN WILTENBURG, Nico

IPC分类号： A61K39/245 ,  A61K39/235 ,  C12N7/08

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/235 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2710/10151 ,  C12N2710/16034 ,  C12N2710/16051 ,  C12N2710/16334 ,  Y10S424/816

摘要： Infectious laryngotracheitis virus (ILTV) and egg drop syndrome virus (EDS) production are currently cultivated in either primary cell cultures or in chicken embryos. These production practices are both costly and difficult. Until now no continuous cell line has been identified which is capable of supporting either ILTV or EDS replication. This invention involves the discovery that a chemically transformed chicken hepatocyte derived cell line is capable of efficiently supporting replication of both ILTV and EDS. Titers of virus harvested from cell culture are sufficient to allow conversion of production from chicken embryo or primary cell culture to continuous cell culture methods.

公开(公告)号：EP0804233A4

公开(公告)日：1998-06-10

申请号：EP94922473

申请日：1994-07-12

申请人： SOLVAY ANIMAL HEALTH INC

发明人： PETERSEN GARY RALPH ,  WELNIAK ELLAN ,  VAN WILTENBURG NICO

IPC分类号： C12N5/06 ,  A61K39/235 ,  A61K39/245 ,  A61P31/12 ,  A61P31/20 ,  A61P31/22 ,  C12N7/00 ,  C12N7/08

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/235 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2710/10151 ,  C12N2710/16034 ,  C12N2710/16051 ,  C12N2710/16334 ,  Y10S424/816

公开(公告)号：EP0325635A4

公开(公告)日：1990-06-26

申请号：EP88906667

申请日：1988-07-11

申请人： ELECTRO NUCLEONICS

发明人： HUNG CHIA-LING

IPC分类号： C12N7/00 ,  C12R1/92

CPC分类号： C12N7/00 ,  C12N2710/16051

公开(公告)号：EP0016552B1

公开(公告)日：1982-10-13

申请号：EP80300546.1

申请日：1980-02-25

申请人： Kendrew Biosystems, Inc.

发明人： Widder, Kenneth, Jon ,  Senyei, Andrew Erwin

IPC分类号： C12N1/02 ,  C12N7/02 ,  C12Q1/00

CPC分类号： C12N7/00 ,  A61K35/12 ,  C12M47/04 ,  C12N1/02 ,  C12N2710/16051 ,  G01N33/5434 ,  G01N33/544 ,  G01N2333/31 ,  G01N2333/76 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84 ,  Y10S436/828

公开(公告)号：EP2310495B1

公开(公告)日：2017-11-22

申请号：EP09807164.0

申请日：2009-08-11

申请人： Sanofi Pasteur Biologics, LLC

发明人： DELAGRAVE, Simon ,  OUBELAID, Rachid ,  HAMBERGER, John

IPC分类号： C12N7/00 ,  C12N7/01 ,  C12N7/02 ,  C12N5/00

CPC分类号： C12N7/00 ,  C12N5/0018 ,  C12N2500/34 ,  C12N2500/36 ,  C12N2500/76 ,  C12N2710/16051 ,  C12N2710/16052

摘要： The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.

公开(公告)号：EP2310495A4

公开(公告)日：2012-01-25

申请号：EP09807164

申请日：2009-08-11

申请人： SANOFI PASTEUR BIOLOGICS CO

发明人： DELAGRAVE SIMON ,  OUBELAID RACHID ,  HAMBERGER JOHN

IPC分类号： C12N7/00 ,  C12N5/00 ,  C12N7/01 ,  C12N7/02

CPC分类号： C12N7/00 ,  C12N5/0018 ,  C12N2500/34 ,  C12N2500/36 ,  C12N2500/76 ,  C12N2710/16051 ,  C12N2710/16052

摘要： The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.

摘要翻译： 本发明涉及改善在细胞培养物中生长的α-疱疹病毒（例如HSV-2）的产量的病毒生长培养基。 本发明的生长培养基包括可添加到无血清或富含血清的生长培养基中以提高病毒生产效率的两种添加剂，二糖和脂质混合物。 本发明进一步提供了在这种生长培养基中产生α-疱疹病毒（例如HSV-2）的方法。