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公开(公告)号：EP2515940A1
公开(公告)日：2012-10-31
申请号：EP10838455.3
申请日：2010-12-20
发明人： HARPER, Kevin , LJUTIC, Belma , GALLICHAN, Scott , OCHS, Martina, Ochs , MOREFIELD, Garry , SALHA, Marie-Danielle , AUSAR, Fernando
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/092 , A61K47/26 , A61K2039/55505
摘要： This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
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公开(公告)号：EP1689867A1
公开(公告)日：2006-08-16
申请号：EP04802183.6
申请日：2004-11-22
IPC分类号： C12N15/31 , A61K39/118 , A61K31/7088 , A61P31/04 , C07H21/00 , C07K14/295 , C07K16/12 , C12P21/02
CPC分类号： C07K14/295 , A61K39/00 , A61K39/118 , A61K2039/53
摘要： The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. The polypeptides are derived from the Chalmydia gene 60kCRMP gene including truncated forms of the gene. The invention further provides recombinant 60kCRMP protein useful for protecting against disease caused by infection with Chlamydia.
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公开(公告)号：EP1615661A2
公开(公告)日：2006-01-18
申请号：EP04727638.1
申请日：2004-04-15
发明人： BERINSTEIN, Neil , GALLICHAN, Scott , LOVITT, Corey , PARRINGTON, Mark , PEDYCZAK, Artur , RADVANYI, Laszlo , SINGH-SANDHU, Devender
IPC分类号： A61K39/00
CPC分类号： C07K14/47
摘要： The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer.
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公开(公告)号：EP3116537A2
公开(公告)日：2017-01-18
申请号：EP15762304.2
申请日：2015-03-10
发明人： GALLICHAN, Scott , LJUTIC, Belma , OCHS-ONOLEMHEMHEN, Martina , SALHA, Marie-danielle , HOPFER, Robert , CHANG, Lee-jah
CPC分类号： A61K39/092 , A61K2039/55 , A61K2039/55505
摘要： This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide, at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e.g., PhtD), and at least one isolated detoxified pneumolysin (e.g., PlyD1) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.
摘要翻译： 本公开涉及包含分离的免疫原性肺炎链球菌PcpA多肽，至少一种另外的抗原（例如分离的免疫原性肺炎链球菌多肽，其选自蛋白质的多组氨酸三联体家族（例如，PhtD ）和至少一种分离的解毒肺炎溶血素（例如PlyD1）以及使用这些组合物预防和治疗由肺炎链球菌引起的疾病的方法。
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公开(公告)号：EP2931743A1
公开(公告)日：2015-10-21
申请号：EP13863211.2
申请日：2013-12-13
IPC分类号： C07K14/315 , C07K7/08 , G01N33/15 , G01N33/567
CPC分类号： G01N33/94 , C07K7/08 , G01N33/6854 , G01N33/9446
摘要： This disclosure relates to methods for detecting the potency of a drug preparation and / or detecting antibodies in a host reactive against one or more antigens.
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公开(公告)号：EP2640418A1
公开(公告)日：2013-09-25
申请号：EP11840988.7
申请日：2011-11-15
发明人： GALLICHAN, Scott , MANCEVSKI, Ausra , REVENEAU, Nathalie , SU, Jin , DALENÇON, François , HAENSLER, Jean
IPC分类号： A61K39/118 , A61P31/04 , A61P37/04 , A61K9/107
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K39/118 , A61K47/44 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/572 , A61K2039/575
摘要： The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as "MOMP"), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C.
trachomatis , C.
pneumoniae , C.
psittaci , or C.
trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C.
trachomatis . The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C.
trachomatis ) in a subject, by administering to the subject a composition of the invention.摘要翻译： 本发明提供了来自至少一种衣原体血清变型和佐剂的包含衣原体主要外膜蛋白（本文中称为“MOMP”）的组合物，其特征在于所述佐剂包含CAS号为287180-63-6的产品E6020。 该组合物可以进一步包含至少一种载体体系（例如乳液，矿物颗粒）。 MOMP蛋白可以来源于衣原体的任何物种（例如沙眼衣原体，肺炎衣原体，鹦鹉热衣原体或沙眼衣原体MoPn）。 在优选的实施方案中，组合物包含一种或多种主要外膜蛋白，每种主要外膜蛋白衍生自沙眼衣原体的不同血清型。 本发明还提供了通过向受试者施用本发明的组合物来诱导受试者对衣原体物种（例如沙眼衣原体）的免疫应答的方法。
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公开(公告)号：EP2515938A1
公开(公告)日：2012-10-31
申请号：EP10838456.1
申请日：2010-12-20
发明人： GALLICHAN, Scott , HARPER, Kevin , LJUTIC, Belma , OCHS, Martina, Ochs , MOREFIELD, Garry , AUSAR, Fernando , SALHA, Marie-Danielle
CPC分类号： A61K39/092 , A61K2039/55505 , C07K16/1275
摘要： This disclosure relates to immunogenic compositions comprising an isolated immunogenic
S. pneumoniae PcpA polypeptide and at least one additional antigen (such as for example, an isolated immunogenic
S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e g. PhtD) and methods of using these compositions for preventing and treating diseases caused by
S. pneumoniae.-
公开(公告)号：EP1687430A1
公开(公告)日：2006-08-09
申请号：EP04818741.3
申请日：2004-11-19
发明人： BRUNHAM, Robert C., UBC Centre for Disease Control , RAUDONIKIENE, Ausra , GALLICHAN, Scott , MURDIN, Andrew
IPC分类号： C12N15/31 , A61K39/118 , A61K31/7088 , A61P31/04 , C07H21/00 , C07K14/295 , C07K16/12 , C12P21/02 , A61K38/16
CPC分类号： A61K39/118 , A61K39/00 , A61K2039/53 , A61K2039/55555 , A61K2039/55577 , C07K14/295
摘要： The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a Mgp002 polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. Truncated forms of the full-length Mgp002 gene are useful immunogens for protecting against disease caused by infection with Chlamydia. The invention further provides recombinant Mgp002 protein useful for protecting against disease caused by infection with Chlamydia.
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