公开(公告)号：EP4129341A1

公开(公告)日：2023-02-08

申请号：EP21781950.7

申请日：2021-02-26

申请人： Santen Pharmaceutical Co., Ltd.

发明人： MOMOKAWA, Yusuke ,  IIDA, Maki ,  ASADA, Hiroyuki ,  FUJISAWA, Toyomi

IPC分类号： A61K47/02 ,  A61J1/05 ,  A61K9/08 ,  A61K31/4704 ,  A61K31/7084 ,  A61K47/32 ,  A61P27/02

摘要： The present invention relates to an ophthalmic aqueous composition containing a silver salt, and filled in a container made of a polyester-based resin, or a container made of a polyolefin-based resin excluding polypropylene. Besides, the present invention also relates to an ophthalmic preservative containing a silver salt, and filled in a container made of a polyester-based resin or a container made of a polyolefin-based resin excluding polypropylene, and a method for imparting, to an ophthalmic aqueous composition, preservative efficacy satisfying a criterion of Preservatives-Effectiveness Tests of The Japanese Pharmacopoeia, including adding a silver salt to the ophthalmic aqueous composition, and filling the ophthalmic aqueous composition in a container made of a polyester-based resin or a container made of a polyolefin-based resin excluding polypropylene. The present invention provides a preservative/system widely usable in ophthalmic aqueous compositions regardless of types of active ingredients and additives.

公开(公告)号：EP3463360A1

公开(公告)日：2019-04-10

申请号：EP17802848.6

申请日：2017-05-24

申请人： Singapore Health Services Pte Ltd ,  Nanyang Technological University ,  Santen Pharmaceutical Co., Ltd.

发明人： TAN, Donald ,  BEUERMAN, Roger ,  ASADA, Hiroyuki ,  TAKAHASHI, Kyohei ,  SAKANAKA, Koji ,  MORIMOTO, Takashi ,  FUJISAWA, Toyomi

IPC分类号： A61K31/46 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K47/38

公开(公告)号：EP3272362A1

公开(公告)日：2018-01-24

申请号：EP16765057.1

申请日：2016-03-17

申请人： Santen Pharmaceutical Co., Ltd.

发明人： OKABE, Komei ,  FUJISAWA, Toyomi ,  YAMADA, Kazuhito

IPC分类号： A61K47/14 ,  A61K31/444 ,  A61K47/10 ,  A61K47/20 ,  A61K47/34 ,  A61P27/02

CPC分类号： A61K31/444 ,  A61K9/0002 ,  A61K9/0048 ,  A61K9/0051 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/34

摘要： The present invention relates to an ophthalmic depot preparation comprising benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulfoxide, wherein the volume ratio of benzyl benzoate and/or benzyl alcohol to polyethylene glycol and/or dimethylsulfoxide in the ophthalmic depot preparation is 75:25 to 25:75, and the total amount of benzyl benzoate and/or benzyl alcohol and polyethylene glycol and/or dimethylsulfoxide contained is 50%(w/w) or more.

摘要翻译： 本发明涉及包含苯甲酸苄酯和/或苯甲醇和聚乙二醇和/或二甲亚砜的眼用储存制剂，其中眼用储存制剂中苯甲酸苄酯和/或苯甲醇与聚乙二醇和/或二甲基亚砜的体积比为 75:25至25:75，并且苯甲酸苄酯和/或苯甲醇和聚乙二醇和/或二甲基亚砜的总量为50％（w / w）或更高。

公开(公告)号：EP4112055A1

公开(公告)日：2023-01-04

申请号：EP22189717.6

申请日：2017-05-24

申请人： Singapore Health Services Pte Ltd ,  Nanyang Technological University ,  Santen Pharmaceutical Co., Ltd.

发明人： TAN, Donald ,  BEUERMAN, Roger ,  ASADA, Hiroyuki ,  SAKANAKA, Koji ,  MORIMOTO, Takashi ,  FUJISAWA, Toyomi ,  TAKAHASHI, Kyohei

IPC分类号： A61K31/46 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K47/38

摘要： Disclosed herein is an aqueous composition comprising 0.001 - 0.1 % (w/v) atropine or a salt thereof, and a phosphate buffer, which is at a pH range of 6 or lower.

公开(公告)号：EP4268827A1

公开(公告)日：2023-11-01

申请号：EP21910965.9

申请日：2021-12-23

申请人： Santen Pharmaceutical Co., Ltd.

发明人： OGURA, Naoki ,  KAJIWARA, Yu ,  FUJISAWA, Koushi ,  ESAKI, Yoshihiko ,  SAKANAKA, Koji ,  FUJISAWA, Toyomi ,  TONE, Yuko

IPC分类号： A61K31/551 ,  A61K9/06 ,  A61K9/107 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44 ,  A61P27/02 ,  A61P27/14 ,  A61P37/08

摘要： The present invention provides a pharmaceutical composition for application to the skin comprising epinastine or a salt thereof in a concentration of 0.05 to 1% (w/w) as an active ingredient which can maintain the concentration of the active ingredient for a long time even at lower concentrations.

公开(公告)号：EP4268825A1

公开(公告)日：2023-11-01

申请号：EP21910981.6

申请日：2021-12-23

申请人： Santen Pharmaceutical Co., Ltd.

发明人： FUJISAWA, Toyomi ,  IKEDA, Hiroyuki

IPC分类号： A61K31/55 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/44 ,  A61P27/02 ,  A61P27/14 ,  A61P39/06

摘要： The present invention provides a pharmaceutical composition for transdermal administration comprising epinastine or a salt thereof as an active ingredient which can maintain the effective concentration of epinastine or a salt thereof in an ocular tissue and stabilize epinastine or a salt thereof in the pharmaceutical composition for a long time.