公开(公告)号：EP2653872A1

公开(公告)日：2013-10-23

申请号：EP11849353.5

申请日：2011-12-05

申请人： Sapporo Medical University

发明人： KOKAI, Yasuo ,  SOHMA, Hitoshi ,  IMAI, Shinichi ,  MATSUMOTO, Kayo ,  KIMURA, Michitoshi

IPC分类号： G01N33/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/6812 ,  G01N2333/4709 ,  G01N2800/2821

摘要： A novel biomarker for diagnosing amyloid β -related neuropathy such as Alzheimer's disease is provided. Disclosed is a method for diagnosing Alzheimer's disease comprising measuring the level of a MFG-E8 protein in a blood, serum or plasma sample obtained from a human or animal subject, wherein the measured value is used as a marker for diagnosis of Alzheimer's disease. The MFG-E8 protein is found to bind to phosphatidylserine in a Ca 2+ dependent manner in a culture supernatant of mouse brain nerve cells, which are a dementia model stimulated with A β 42 . It is also found that the level of the MFG-E8 protein is increased in patients with Alzheimer's disease.

公开(公告)号：EP2653872B1

公开(公告)日：2017-02-22

申请号：EP11849353.5

申请日：2011-12-05

申请人： Sapporo Medical University

发明人： KOKAI, Yasuo ,  SOHMA, Hitoshi ,  IMAI, Shinichi ,  MATSUMOTO, Kayo ,  KIMURA, Michitoshi

IPC分类号： G01N33/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/6812 ,  G01N2333/4709 ,  G01N2800/2821