公开(公告)号：EP2653872A1

公开(公告)日：2013-10-23

申请号：EP11849353.5

申请日：2011-12-05

申请人： Sapporo Medical University

发明人： KOKAI, Yasuo ,  SOHMA, Hitoshi ,  IMAI, Shinichi ,  MATSUMOTO, Kayo ,  KIMURA, Michitoshi

IPC分类号： G01N33/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/6812 ,  G01N2333/4709 ,  G01N2800/2821

摘要： A novel biomarker for diagnosing amyloid β -related neuropathy such as Alzheimer's disease is provided. Disclosed is a method for diagnosing Alzheimer's disease comprising measuring the level of a MFG-E8 protein in a blood, serum or plasma sample obtained from a human or animal subject, wherein the measured value is used as a marker for diagnosis of Alzheimer's disease. The MFG-E8 protein is found to bind to phosphatidylserine in a Ca 2+ dependent manner in a culture supernatant of mouse brain nerve cells, which are a dementia model stimulated with A β 42 . It is also found that the level of the MFG-E8 protein is increased in patients with Alzheimer's disease.

公开(公告)号：EP2163896A1

公开(公告)日：2010-03-17

申请号：EP08764208.8

申请日：2008-06-23

申请人： Sapporo Medical University ,  Immuno-Biological Laboratories Co., Ltd.

发明人： HORI, Tsukasa ,  KOKAI, Yasuo ,  NAISHIRO, Yasuyoshi ,  TSUTSUMI, Hiroyuki ,  IMAI, Kohzoh

IPC分类号： G01N33/53 ,  A61K39/395 ,  A61P37/06 ,  G01N27/62 ,  G01N30/72 ,  G01N30/88 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K16/24 ,  A61K2039/505 ,  G01N33/6863 ,  G01N2030/8831 ,  G01N2333/523 ,  G01N2800/245

摘要： Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody.

摘要翻译： 公开了一种诊断移植物抗宿主病的方法，包括测量从受试者获得的样品中CCL8蛋白的水平，作为移植物抗宿主病的诊断或过程的指标。 还公开了包含抗CCL8抗体的用于移植物抗宿主病的诊断试剂。 本发明的方法能够诊断移植物抗宿主疾病的发作和监测进展，特别是移植物抗宿主疾病与传染病之间的鉴别诊断。 本发明还提供了利用抗CCL8抗体治疗移植物抗宿主病的方法。

公开(公告)号：EP2653872B1

公开(公告)日：2017-02-22

申请号：EP11849353.5

申请日：2011-12-05

申请人： Sapporo Medical University

发明人： KOKAI, Yasuo ,  SOHMA, Hitoshi ,  IMAI, Shinichi ,  MATSUMOTO, Kayo ,  KIMURA, Michitoshi

IPC分类号： G01N33/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/6812 ,  G01N2333/4709 ,  G01N2800/2821

公开(公告)号：EP2163896B1

公开(公告)日：2013-09-25

申请号：EP08764208.8

申请日：2008-06-23

申请人： Sapporo Medical University

发明人： HORI, Tsukasa ,  KOKAI, Yasuo ,  NAISHIRO, Yasuyoshi ,  TSUTSUMI, Hiroyuki ,  IMAI, Kohzoh

IPC分类号： C07K16/24 ,  G01N33/53 ,  A61K39/395 ,  A61P37/06 ,  G01N27/62 ,  G01N30/72 ,  G01N30/88 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68

CPC分类号： C07K16/24 ,  A61K2039/505 ,  G01N33/6863 ,  G01N2030/8831 ,  G01N2333/523 ,  G01N2800/245