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公开(公告)号：EP3118326A2
公开(公告)日：2017-01-18
申请号：EP16164792.0
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号：EP2361988B1
公开(公告)日：2016-04-13
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
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公开(公告)号：EP3118326A3
公开(公告)日：2017-05-31
申请号：EP16164792.0
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译： 一种用于检测作为感兴趣对象的细胞团中的癌症干细胞的分子标记，其中所述分子标记可以在感兴趣对象中包含的癌症干细胞中检测到，但是不能在正常细胞和癌细胞中检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定目标受试者中癌症干细胞的存在或不存在的方法; 用于确定癌症干细胞的存在或不存在的试剂盒，其至少包含用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别源自分子标记的基因的表达产物的表位的抗体; 能够抑制分子标记表达的核酸; 以及包含衍生自分子标记的基因的核酸疫苗。
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公开(公告)号：EP3020806A1
公开(公告)日：2016-05-18
申请号：EP14823622.7
申请日：2014-07-11
发明人： MASUDA, Keiki , IGUCHI, Haruhisa , GOTO, Masashi , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , MORITA, Rena
CPC分类号： A61K39/0011 , A61K38/177 , A61K2039/55566 , A61K2039/57 , C07K14/4747 , C07K14/705 , C07K14/70539 , C07K16/2833 , C07K16/30 , C07K2317/32
摘要： Provided is a tumor antigen peptide and the like that is useful in the prevention and/or treatment of cancer. The present invention pertains to: a peptide comprising the amino acid sequence of sequence number 3, sequence number 4, sequence number 5, sequence number 6, or sequence number 11; a polyepitope peptide resulting from joining a plurality of epitope peptides and containing at least one of the aforementioned peptides as one epitope peptide; a polynucleotide coding for at least one of the polyepitope peptides or the peptides; a pharmaceutical composition containing the above as active ingredients; a cancer prevention and/or treatment agent characterized by inducing CTLs; and the like.
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公开(公告)号：EP2361988A1
公开(公告)日：2011-08-31
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译： 用于检测作为感兴趣对象的细胞团中的癌干细胞的分子标记物，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这不同于癌症干细胞; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 以及包含衍生自所述分子标记的基因的核酸疫苗。
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公开(公告)号：EP2361988A9
公开(公告)日：2012-02-22
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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