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公开(公告)号：EP3118326A2
公开(公告)日：2017-01-18
申请号：EP16164792.0
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号：EP3231867A1
公开(公告)日：2017-10-18
申请号：EP15867698.1
申请日：2015-12-08
发明人： SATO, Noriyuki , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , KANASEKI, Takayuki , MIYAMOTO, Sho , KOCHIN, Vitaly , GOTO, Masashi
IPC分类号： C12N15/09 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K16/30 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574
CPC分类号： A61K39/0011 , A61K39/00 , A61K48/00 , A61K2039/572 , C07K7/06 , C07K16/2833 , C07K16/30 , C07K2317/34 , C12N5/0638 , C12N15/09 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/15 , G01N33/50 , G01N33/5088 , G01N33/574 , G01N2333/46
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by Y o -X o -Z o ; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 肿瘤干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，所述药物组合物包含上述肿瘤抗原肽作为活性成分; 筛选肿瘤抗原肽的方法; 为实现上述目的，提供了：由Yo-Xo-Zo代表的肽; 由多个连接在一起的表位肽组成的多表位肽，所述多表位肽含有至少一种上述肽作为表位肽之一; 编码上述肽和/或多表位肽的多核苷酸; 包含其作为活性成分的药物组合物; 特征在于诱导CTL的癌症的预防和/或治疗剂; 等等
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公开(公告)号：EP3118326A3
公开(公告)日：2017-05-31
申请号：EP16164792.0
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译： 一种用于检测作为感兴趣对象的细胞团中的癌症干细胞的分子标记，其中所述分子标记可以在感兴趣对象中包含的癌症干细胞中检测到，但是不能在正常细胞和癌细胞中检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定目标受试者中癌症干细胞的存在或不存在的方法; 用于确定癌症干细胞的存在或不存在的试剂盒，其至少包含用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别源自分子标记的基因的表达产物的表位的抗体; 能够抑制分子标记表达的核酸; 以及包含衍生自分子标记的基因的核酸疫苗。
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公开(公告)号：EP3020806A1
公开(公告)日：2016-05-18
申请号：EP14823622.7
申请日：2014-07-11
发明人： MASUDA, Keiki , IGUCHI, Haruhisa , GOTO, Masashi , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , MORITA, Rena
CPC分类号： A61K39/0011 , A61K38/177 , A61K2039/55566 , A61K2039/57 , C07K14/4747 , C07K14/705 , C07K14/70539 , C07K16/2833 , C07K16/30 , C07K2317/32
摘要： Provided is a tumor antigen peptide and the like that is useful in the prevention and/or treatment of cancer. The present invention pertains to: a peptide comprising the amino acid sequence of sequence number 3, sequence number 4, sequence number 5, sequence number 6, or sequence number 11; a polyepitope peptide resulting from joining a plurality of epitope peptides and containing at least one of the aforementioned peptides as one epitope peptide; a polynucleotide coding for at least one of the polyepitope peptides or the peptides; a pharmaceutical composition containing the above as active ingredients; a cancer prevention and/or treatment agent characterized by inducing CTLs; and the like.
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公开(公告)号：EP2361988B1
公开(公告)日：2016-04-13
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574 , A61K48/00 , A61K49/00 , G01N33/50
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
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公开(公告)号：EP3199627A1
公开(公告)日：2017-08-02
申请号：EP15843390.4
申请日：2015-09-24
发明人： TORIGOE, Toshihiko , ATSUYAMA, Eri , OTAKA, Hironori , NAKANO, Kazue , LI, Dongliang , TOJI, Shingo , ASANO, Takuya , HORIBE, Ryota , HIROHASHI, Yoshihiko , SATO, Noriyuki , SAITO, Tsuyoshi
IPC分类号： C12N15/00 , A61K35/76 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C07K7/06 , C12N5/10 , C12N15/09 , C07K14/82
CPC分类号： C07K14/4703 , A61K35/76 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K14/82 , C07K16/18 , C07K16/30 , C12N5/0634 , C12N5/0638 , C12N5/10 , C12N15/00 , C12N15/09 , C12N2510/00 , G01N33/57496 , G01N2333/4704
摘要： The object is to provide a tumor antigen peptide that is specifically presented on a cancer and a cancer stem cell, and a pharmaceutical composition, etc. that is useful for the prevention and/or treatment of a cancer and contains the above peptide as an active ingredient.
The above object has been accomplished by providing a BORIS-derived partial peptide belonging to isoform A or C or subfamily 5 or 6, a polynucleotide encoding the peptide, a pharmaceutical composition containing the above as an active ingredient, and an agent for the prevention and/or treatment of a cancer, the agent containing the above as an active ingredient and inducing CTLs.摘要翻译： 本发明的目的在于提供可用于癌症的预防和/或治疗的含有上述肽作为有效成分的癌症和癌干细胞上特异性表达的肿瘤抗原肽和药物组合物等 成分。 上述目的通过提供属于同种型A或C或亚科5或6的BORIS衍生的部分肽，编码该肽的多核苷酸，含有上述作为活性成分的药物组合物，以及用于预防和 /或治疗癌症，包含上述作为活性成分并诱导CTL的试剂。
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公开(公告)号：EP3054010B1
公开(公告)日：2020-07-22
申请号：EP14850688.4
申请日：2014-10-03
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公开(公告)号：EP2361988A9
公开(公告)日：2012-02-22
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号：EP3054010A1
公开(公告)日：2016-08-10
申请号：EP14850688.4
申请日：2014-10-03
发明人： SATO, Noriyuki , TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , KANASEKI, Takayuki , KOCHIN, Vitaly , TAKAYA, Akari , GOTO, Masashi
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K16/28 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO-XO-ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.
摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 癌症干细胞特异表现的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，其含有作为其有效成分的药物组合物; 和筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽，包含至少一种所述肽作为表位肽并且具有连接在其中的多个表位肽的多表位肽，编码至少肽或多表位肽的多核苷酸，药物组合物 含有这些作为其有效成分的化合物，以及以诱导CTL为特征的癌症预防和/或治疗剂。
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公开(公告)号：EP2361988A1
公开(公告)日：2011-08-31
申请号：EP09823303.4
申请日：2009-10-27
发明人： TORIGOE, Toshihiko , HIROHASHI, Yoshihiko , SATOH, Noriyuki , KAMIGUCHI, Kenjiro , MORITA, Rena , NISHIZAWA, Satoshi , TAKAHASHI, Akari
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K47/42 , A61P35/00 , C07K16/18 , C12N15/09 , G01N33/574
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译： 用于检测作为感兴趣对象的细胞团中的癌干细胞的分子标记物，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这不同于癌症干细胞; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 以及包含衍生自所述分子标记的基因的核酸疫苗。
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