公开(公告)号：EP1898960A1

公开(公告)日：2008-03-19

申请号：EP06762277.9

申请日：2006-06-29

申请人： Schering AG ,  Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： BRIEL, Andreas ,  GLEICH, Bernhard ,  WEIZENECKER, Jürgen ,  ROHRER, Martin ,  WEINMANN, Hanns-Joachim ,  PIETSCH, Hubertus ,  LAWACZECK, Rüdiger ,  ROTHE, Matthias ,  THOMSEN, Jens

IPC分类号： A61K49/18

CPC分类号： A61B5/418 ,  A61B5/0515 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61K49/1836 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00

摘要： The present invention relates to complexes which contain polycrystalline magnetic iron oxide particles in a pharmaceutically acceptable shell, and to the use of these compositions in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.

摘要翻译： 粒子（A），其包括磁性氧化铁核心的多晶涂层的直径为20纳米至1微米，是新的。 独立权利要求中包括了：（1）制备（A），其包括wässrige铁盐溶液的含亚铁盐和铁盐与碱wässrige中的合成的（共）聚合物，淀粉或其衍生物，葡聚糖存在下溶液的混合 或其衍生物，环糊精或其衍生物，脂肪酸，多糖，卵磷脂和/或单 - ，二 - 或三酸甘油酯或其衍生物，以得到其（A）将包含所述溶液到磁性胶体溶液（A） 梯度场，在去除磁场并提取（A）中的梯度场; （2）包含（A）的组合物; 和（3）的液体包含所述组合物。

公开(公告)号：EP1898959A1

公开(公告)日：2008-03-19

申请号：EP06762276.1

申请日：2006-06-29

申请人： Bayer Schering Pharma Aktiengesellschaft ,  Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： BRIEL, Andreas ,  GLEICH, Bernhard ,  WEIZENECKER, Jürgen ,  ROHRER, Martin ,  WEINMANN, Hanns-Joachim ,  PIETSCH, Hubertus ,  LAWACZECK, Rüdiger ,  ROTHE, Matthias ,  THOMSEN, Jens

IPC分类号： A61K49/18

CPC分类号： A61B5/418 ,  A61B5/0515 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61K49/1836 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00

摘要： The present invention relates to complexes which contain magnetic iron oxide particles in a pharmaceutically acceptable shell, said particles having a diameter of 20 nm to 1 µm with an overall particle diameter/core diameter ratio of less than 6, and to the use of these complexes in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.

公开(公告)号：EP1450864A2

公开(公告)日：2004-09-01

申请号：EP02794507.0

申请日：2002-07-18

申请人： Schering AG

发明人： PLATZEK, Johannes ,  SCHMITT-WILLICH, Heribert ,  MICHL, Günther ,  FRENZEL, Thomas ,  SÜLZLE, Detlev ,  BAUER, Hans ,  RADÜCHEL, Bernd ,  WEINMANN, Hanns-Joachim ,  SCHIRMER, Heiko

IPC分类号： A61K49/08 ,  A61K49/00

CPC分类号： A61K49/14 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/143

摘要： The invention relates to conjugates comprised of macrocyclic metal complexes with biomolecules and to the production thereof. The conjugates are suited for use as contrast agents in NMR diagnosis and radiodiagnosis and as agents for radiotherapy. A high relaxivity is achieved and a fine tuning of the relaxivity is made possible by a special liganding of the macrocycles.

公开(公告)号：EP1409024A1

公开(公告)日：2004-04-21

申请号：EP02754904.7

申请日：2002-07-18

申请人： Schering AG

发明人： PLATZEK, Johannes ,  SCHMITT-WILLICH, Heribert ,  MICHL, Günther ,  FRENZEL, Thomas ,  SÜLZLE, Detlev ,  BAUER, Hans ,  RADÜCHEL, Bernd ,  WEINMANN, Hanns-Joachim ,  SCHIRMER, Heiko

IPC分类号： A61K47/48 ,  A61K49/00 ,  C07D257/02 ,  C07F5/00

CPC分类号： A61K49/10 ,  A61K47/54 ,  A61K47/547 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/14 ,  A61K49/143 ,  C07D257/02

摘要： The invention relates to macrocyclic metal complexes and production and use thereof for production of conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR and radio diagnostics and for radiotherapy. According to the invention, a high relaxivity and a fine-tuning of the relaxivity may be achieved by means of a special ligand formation with the macrocycles.