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    N-OXIDANTHRANYLAMID-DERIVATE UND DEREN VERWENDUNG ALS ARZNEIMITTEL
    2.
    发明公开
    N-OXIDANTHRANYLAMID-DERIVATE UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开
    N-二OXIDANTHRANYLAMID衍生物及其药物AS

    公开(公告)号：EP1389201A1

    公开(公告)日：2004-02-18

    申请号：EP02740563.8

    申请日：2002-05-03

    申请人： SCHERING AKTIENGESELLSCHAFT

    发明人： ERNST, Alexander ,  HUTH, Andreas ,  KRÜGER, Martin ,  THIERAUCH, Karl-Heinz ,  MENRAD, Andreas ,  HABEREY, Martin

    IPC分类号： C07D401/12 ,  C07D405/12 ,  C07D213/89 ,  A61K31/47 ,  A61P35/00

    CPC分类号： C07D213/89 ,  C07D401/12 ,  C07D405/12

    摘要： The invention relates to substituted N-oxide anthranylamide derivatives, to the production thereof and to their use as medicaments for treating diseases that are triggered by persistent angiogenesis. The inventive compounds can be used in the case of psoriasis, Kaposi's sarcoma, restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia, arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma, eye diseases, such as diabetic retinopathy, neovascular glaucoma, renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombotic microangiopathic syndromes, transplant rejections and glomerulopathy, fibrotic diseases such as cirrhosis of the liver, mesangial cell-proliferative diseases, arteriosclerosis, injuries of the nerve tissue, and for inhibiting the reocclusion of vessels after balloon catheter treatment, for use in vascular prosthetics or after inserting mechanical devices for holding vessels open such as, e.g. stents, as immunosuppressants, as an aid in scar-free wound healing, and for treating age spots and contact dermatitis. The inventive compounds can also be used as VEGFR-3 inhibitors in lymphangiogenesis.

    20-METHYL-SUBSTITUIERTE VITAMIN D-DERIVATE
    5.
    发明授权
    20-METHYL-SUBSTITUIERTE VITAMIN D-DERIVATE 失效
    20甲基取代的维生素D衍生物

    公开(公告)号：EP0637299B1

    公开(公告)日：1996-05-22

    申请号：EP92924724.5

    申请日：1992-12-14

    申请人： SCHERING AKTIENGESELLSCHAFT

    发明人： NEEF, Günter ,  STEINMEYER, Andreas ,  KIRSCH, Gerald ,  SCHWARZ, Katica ,  THIEROFF-Ekerdt, Ruth ,  WIESINGER, Herbert ,  HABEREY, Martin

    IPC分类号： C07C401/00 ,  A61K31/59

    CPC分类号： C07C401/00

    摘要： New 20-methyl-substituted vitamin D derivates have general formula (I), in which R1 is a hydrogen atom, a hydroxyl group or an alkanoyloxyl group with 1 to 12 carbon atoms or a benzoyloxyl group, R2 is a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group; and R3 is saturated or unsaturated, straight-chain or branched-chain hydrocarbon residue with up to 18 C atoms, possibly interrupted and/or substituted by one or several carbocyclic structures (C¿3-10?-cycloalkyl or cycloakenyl residues, the latter having up to 2 double bonds), possibly substituted by one or several hydroxyl, oxo, amino groups and/or by one or several halogen atoms, possibly having one or several oxygen, sulphur and/or nitrogen (as (a)) atoms as chaining members in the hydrocarbon residue. Also disclosed is a process for preparing the same. These new compounds have a strongly improved induction of cell differentiation (HL-60), with respect to calcitriol, and are suitable for preparing medicaments.

    20-METHYL-SUBSTITUIERTE VITAMIN D-DERIVATE
    10.
    发明公开
    20-METHYL-SUBSTITUIERTE VITAMIN D-DERIVATE 失效
    20甲基取代的维生素D衍生物。

    公开(公告)号：EP0637299A1

    公开(公告)日：1995-02-08

    申请号：EP92924724.0

    申请日：1992-12-14

    申请人： SCHERING AKTIENGESELLSCHAFT

    发明人： NEEF, Günter ,  STEINMEYER, Andreas ,  KIRSCH, Gerald ,  SCHWARZ, Katica ,  THIEROFF-Ekerdt, Ruth ,  WIESINGER, Herbert ,  HABEREY, Martin

    IPC分类号： A61K31 ,  A61P3 ,  A61P17 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07C401

    CPC分类号： C07C401/00

    摘要： New 20-methyl-substituted vitamin D derivates have general formula (I), in which R1 is a hydrogen atom, a hydroxyl group or an alkanoyloxyl group with 1 to 12 carbon atoms or a benzoyloxyl group, R2 is a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group; and R3 is saturated or unsaturated, straight-chain or branched-chain hydrocarbon residue with up to 18 C atoms, possibly interrupted and/or substituted by one or several carbocyclic structures (C¿3-10?-cycloalkyl or cycloakenyl residues, the latter having up to 2 double bonds), possibly substituted by one or several hydroxyl, oxo, amino groups and/or by one or several halogen atoms, possibly having one or several oxygen, sulphur and/or nitrogen (as (a)) atoms as chaining members in the hydrocarbon residue. Also disclosed is a process for preparing the same. These new compounds have a strongly improved induction of cell differentiation (HL-60), with respect to calcitriol, and are suitable for preparing medicaments.