公开(公告)号：EP2318388A2

公开(公告)日：2011-05-11

申请号：EP09775391.7

申请日：2009-07-21

申请人： Schering Corporation

发明人： MCCORMICK, Kevin D. ,  ASLANIAN, Robert G. ,  MANGIARACINA, Pietro ,  BERLIN, Michael Y. ,  DE LERA RUIZ, Manuel ,  BOYCE, Christopher W ,  CHAO, Jianhua ,  TING, Pauline C. ,  ZHENG, Junying ,  ROSENBLUM, Stuart B.

IPC分类号： C07D401/06

CPC分类号： C07D471/10 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D491/107 ,  C07D491/20 ,  C07D495/20 ,  C07D498/10

摘要： The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

摘要翻译： 本发明涉及新的三环螺环衍生物，包含三环螺环衍生物的药物组合物以及这些化合物用于治疗或预防过敏症，过敏引起的气道反应，充血，心血管疾病，炎性疾病，胃肠道病症， 神经系统疾病，代谢疾病，肥胖或肥胖相关疾病，糖尿病，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。

公开(公告)号：EP2344491A2

公开(公告)日：2011-07-20

申请号：EP09792551.5

申请日：2009-09-15

申请人： Schering Corporation

发明人： BOYCE, Christopher W ,  CHAO, Jianhua ,  MCCORMICK, Kevin D.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D491/052

摘要： In its many embodiments, the present invention provides a novel class of azanitrile compounds as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

公开(公告)号：EP2356106A1

公开(公告)日：2011-08-17

申请号：EP09793312.1

申请日：2009-10-06

申请人： Schering Corporation

发明人： MCCORMICK, Kevin D. ,  DONG, Li ,  BOYCE, Christopher W ,  DE LERA RUIZ, Manuel ,  FEVRIER, Salem ,  WU, Jie ,  ZHENG, Junying ,  YU, Younong ,  CHAO, Jianhua ,  WON, Walter S. ,  RAO, Ashwin U. ,  KUANG, Rongze ,  TING, Pauline C. ,  HUANG, Xianhai ,  SHAO, Ning ,  PALANI, Anandan ,  BERLIN, Michael Y. ,  ASLANIAN, Robert G.

IPC分类号： C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D235/02 ,  C07D263/52 ,  C07D498/10 ,  C07D519/00 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/424 ,  A61P11/02

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/501 ,  A61K31/506 ,  A61K31/537 ,  C07D235/02 ,  C07D263/52 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D471/04 ,  C07D498/10 ,  C07D519/00

摘要： In its many embodiments, the present invention provides a novel class of biaryi spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新的二氨基螺氨基恶唑啉类似物作为α2C肾上腺素能受体激动剂的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物 以及使用这些化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。