公开(公告)号：EP1931657A2

公开(公告)日：2008-06-18

申请号：EP06801601.3

申请日：2006-08-16

申请人： Schering Corporation

发明人： DENG, Yongqi ,  CURRAN, Patrick, J. ,  SHIPPS, Gerald W., Jr. ,  ZHAO, Lianyun ,  SIDDIQUI, M. Arshad ,  POPOVICI-MULLER, Janeta ,  DUCA, Jose, S. ,  HRUZA, Alan, W. ,  FISCHMANN, Thierry, O. ,  MADISON, Vincent, S. ,  ZHANG, Rumin ,  MCNEMAR, Charles, Wayne ,  MAYHOOD, Todd, W. ,  WINDSOR, William, T. ,  LEES, Emma, M. ,  PARRY, David, A.

IPC分类号： C07D409/04 ,  C07D215/50 ,  C07D215/42 ,  C07D401/12 ,  C07D401/10 ,  C07D405/04 ,  C07D215/48 ,  C07D413/12 ,  C07D417/10 ,  C07D401/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/06 ,  C07D401/14

CPC分类号： C07D409/04 ,  C07D215/42 ,  C07D215/48 ,  C07D215/50 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10

摘要： Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.