公开(公告)号：EP1871765A2

公开(公告)日：2008-01-02

申请号：EP06719337.5

申请日：2006-01-24

申请人： Schering Corporation

发明人： CHAN, Tin-yau ,  FISCHMANN, Thierry, O. ,  MC COY, Mark, A. ,  MC KITTRICK, Brian ,  PRONGAY, Andrew ,  PU, Haiyan ,  WANG, Li ,  XIAO, Li

IPC分类号： C07D403/04 ,  A61P35/00

CPC分类号： C07D403/04

摘要： The present invention relates to indazolyl (1;2,4) triazine compounds having the general structure of Formula (I); useful as protein kinase inhibitors, pharmaceutical compositions comprising such compounds, and methods of treatment using the compounds and compositions to treat conditions such as cancer and proliferative diseases or immunodeficiencies, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease. The substituents are defined in the claims.

公开(公告)号：EP1931657A2

公开(公告)日：2008-06-18

申请号：EP06801601.3

申请日：2006-08-16

申请人： Schering Corporation

发明人： DENG, Yongqi ,  CURRAN, Patrick, J. ,  SHIPPS, Gerald W., Jr. ,  ZHAO, Lianyun ,  SIDDIQUI, M. Arshad ,  POPOVICI-MULLER, Janeta ,  DUCA, Jose, S. ,  HRUZA, Alan, W. ,  FISCHMANN, Thierry, O. ,  MADISON, Vincent, S. ,  ZHANG, Rumin ,  MCNEMAR, Charles, Wayne ,  MAYHOOD, Todd, W. ,  WINDSOR, William, T. ,  LEES, Emma, M. ,  PARRY, David, A.

IPC分类号： C07D409/04 ,  C07D215/50 ,  C07D215/42 ,  C07D401/12 ,  C07D401/10 ,  C07D405/04 ,  C07D215/48 ,  C07D413/12 ,  C07D417/10 ,  C07D401/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/06 ,  C07D401/14

CPC分类号： C07D409/04 ,  C07D215/42 ,  C07D215/48 ,  C07D215/50 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10

摘要： Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

公开(公告)号：EP1871765B1

公开(公告)日：2009-12-09

申请号：EP06719337.5

申请日：2006-01-24

申请人： Schering Corporation

发明人： CHAN, Tin-yau ,  FISCHMANN, Thierry, O. ,  MC COY, Mark, A. ,  MC KITTRICK, Brian ,  PRONGAY, Andrew ,  PU, Haiyan ,  WANG, Li ,  XIAO, Li

IPC分类号： C07D403/04 ,  A61P35/00

CPC分类号： C07D403/04

摘要： The present invention relates to indazolyl (1;2,4) triazine compounds having the general structure of Formula (I); useful as protein kinase inhibitors, pharmaceutical compositions comprising such compounds, and methods of treatment using the compounds and compositions to treat conditions such as cancer and proliferative diseases or immunodeficiencies, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease. The substituents are defined in the claims.

公开(公告)号：EP2078003A1

公开(公告)日：2009-07-15

申请号：EP07853013.6

申请日：2007-10-29

申请人： Schering Corporation

发明人： SHIPPS, Gerald, W., Jr. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  FISCHMANN, Thierry, O. ,  DUCA, Jose, S. ,  RICHARDS, Matthew ,  ZENG, Hongbo ,  SUN, Binyuan ,  REDDY, Panduranga, A. ,  WONG, Tzu, T. ,  TADIKONDA, Praveen, K. ,  SIDDIQUI, M., Arshad ,  LABROLI, Marc, M. ,  POKER, Cory ,  GUZI, Timothy, J.

IPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10

摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。

公开(公告)号：EP1534712A2

公开(公告)日：2005-06-01

申请号：EP03796321.2

申请日：2003-09-03

申请人： SCHERING CORPORATION ,  PHARMACOPEIA, INC.

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  ALVAREZ, Carmen, S. ,  CHAN, Tin-Yau ,  KNUTSON, Chad ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP2078002A1

公开(公告)日：2009-07-15

申请号：EP07853011.0

申请日：2007-10-29

申请人： Schering Corporation

发明人： SHIPPS, Gerald, W., Jr. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  FISCHMANN, Thierry, O. ,  DUCA, Jose, S. ,  RICHARDS, Matthew

IPC分类号： C07D277/56 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/501 ,  A61K31/4427 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D277/56 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

公开(公告)号：EP1534712B1

公开(公告)日：2007-05-16

申请号：EP03796321.2

申请日：2003-09-03

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  ALVAREZ, Carmen, S. ,  CHAN, Tin-Yau ,  KNUTSON, Chad ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP1537116A1

公开(公告)日：2005-06-08

申请号：EP03794592.0

申请日：2003-09-03

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  MALLAMS, Alan ,  ALVAREZ, Carmen, S. ,  KEERTIKAR, Kartik, M. ,  RIVERA, Jocelyn ,  CHAN, Tin-Yau ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon ,  PARADKAR, Vidyadhar, M. ,  HOBBS, Douglas, Walsh

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP1537116B1

公开(公告)日：2010-06-02

申请号：EP03794592.0

申请日：2003-09-03

申请人： Schering Corporation ,  Pharmacopeia, LLC

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  DOLL, Ronald, J. ,  GIRIJAVALLABHAN, Viyyoor, Moopil ,  MALLAMS, Alan ,  ALVAREZ, Carmen, S. ,  KEERTIKAR, Kartik, M. ,  RIVERA, Jocelyn ,  CHAN, Tin-Yau ,  MADISON, Vincent ,  FISCHMANN, Thierry, O. ,  DILLARD, Lawrence, W. ,  TRAN, Vinh, D. ,  HE, Zhen Min ,  JAMES, Ray, Anthony ,  PARK, Haengsoon ,  PARADKAR, Vidyadhar, M. ,  HOBBS, Douglas, Walsh

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：EP2078004A1

公开(公告)日：2009-07-15

申请号：EP07853035.9

申请日：2007-10-29

申请人： Schering Corporation

发明人： SHIPPS, Gerald, W., Jr. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  FISCHMANN, Thierry, O. ,  DUCA, Jose, S. ,  RICHARDS, Matthew ,  ZENG, Hongbo ,  SUN, Binyuan ,  REDDY, Panduranga, A. ,  ZHAO, Lianyun ,  TANG, Shuyi ,  WONG, Tzu, T. ,  TADIKONDA, Praveen, K. ,  TORRES, Luis, E. ,  SIDDIQUI, M., Arshad ,  DWYER, Michael, P. ,  KEERTIKAR, Kartik, M. ,  GUZI, Timothy, J.

IPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04 ,  A61K31/501 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D277/56 ,  A61K31/435 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04 ,  A61K2300/00

摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.