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1.发明授权BENZPYRIDO CYCLOHEPTANE COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE 失效与蛋白质法尼基转移抑制作用BENZPYRIDO环庚烷衍生物
公开(公告)号：EP0989983B1
公开(公告)日：2004-08-11
申请号：EP98928886.5
申请日：1998-06-15
发明人： COOPER, Alan, B. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, M. , GANGULY, Ashit , READER, John, C. , BALDWIN, John, J. , HUANG, Chia-yu
IPC分类号： C07D401/14 , A61K31/55 , C07D401/04 , A61K31/495 , A61K31/44
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14
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2.发明公开
公开(公告)号：EP1140909A1
公开(公告)日：2001-10-10
申请号：EP99965906.3
申请日：1999-12-22
发明人： COOPER, Alan, B. , DOLL, Ronald, J. , FERREIRA, Johan, A. , GANGULY, Ashit , GIRIJAVALLABHAN, Viyyoor, M. , TAVERAS, Arthur, G. , CHAO, Jianping , BALDWIN, John, J. , HUANG, Chia-Yu , LI, Ge
IPC分类号： C07D403/12 , C07D401/14 , C07D241/04 , A61K31/496 , A61P35/00
CPC分类号： C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D401/14 , C07D403/12
摘要： Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
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3.发明公开3,4-DI-SUBSTITUTED MALEIMIDE COMPOUNDS AS CXC-CHEMOKINE RECEPTOR ANTAGONISTS 审中-公开3,4-二取代的马来酰亚胺衍生物作为CXC趋化因子受体拮抗剂
公开(公告)号：EP1434775A1
公开(公告)日：2004-07-07
申请号：EP02786395.0
申请日：2002-10-11
发明人： TAVERAS, Arthur, G. , DWYER, Michael , FERREIRA, Johan, A. , GIRIJAVALLABHAN, Viyyoor, M. , CHAO, Jianping , BALDWIN, John, J. , MERRITT, J., Robert , LI, Ge
IPC分类号： C07D409/12 , C07D405/12 , C07D207/44 , C07D401/08 , C07D403/12 , C07D401/12 , C07D409/14 , C07D417/12 , A61K31/4015 , A61K31/4025 , A61P35/00
CPC分类号： C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
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4.发明公开BENZPYRIDO CYCLOHEPTANE COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE 失效与蛋白质法尼基转移抑制作用BENZPYRIDO环庚烷衍生物
公开(公告)号：EP0989983A1
公开(公告)日：2000-04-05
申请号：EP98928886.5
申请日：1998-06-15
发明人： COOPER, Alan, B. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, M. , GANGULY, Ashit , READER, John, C. , BALDWIN, John, J. , HUANG, Chia-yu
IPC分类号： C07D401/14 , A61K31/55 , C07D401/04 , A61K31/495 , A61K31/44
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14
摘要： Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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公开(公告)号：EP1664092B1
公开(公告)日：2011-02-02
申请号：EP04784827.0
申请日：2004-09-23
申请人： Schering Corporation
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , WU, Wanli , GIRIJAVALLABHAN, Viyyoor, M. , MCKITTRICK, Brian , SU, Jing , VELAZQUEZ, Francisco , PINTO, Patrick, A.
IPC分类号： C07K5/12 , C07D245/00 , A61K38/12
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula (1): wherein Z', L', M', R1, X and D are defined herein.
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公开(公告)号：EP1660477B1
公开(公告)日：2008-12-10
申请号：EP04779960.6
申请日：2004-08-04
申请人： Schering Corporation
发明人： ZHU, Hugh, Y. , COOPER, Alan, B. , DESAI, Jagdish, A. , WANG, James, J-S. , RANE, Dinanath, F. , DOLL, Ronald, J. , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D401/06 , C07D401/14 , A61K31/415 , A61P35/00
CPC分类号： C07D401/06
摘要： Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
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公开(公告)号：EP1543008B1
公开(公告)日：2007-11-07
申请号：EP03754658.7
申请日：2003-09-19
申请人： Schering Corporation
发明人： PARUCH, Kamil , GUZI, Timothy, J. , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, M. , MALLAMS, Alan, K.
IPC分类号： C07D487/04 , A61K31/495 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds of formula (III) as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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8.发明公开ACYLSULFONAMIDE COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE 有权丙型肝炎病毒的NS3丝氨酸蛋白酶的ACYLSULFONAMIDVERBINDUNGEN作为抑制剂
公开(公告)号：EP1797111A1
公开(公告)日：2007-06-20
申请号：EP05790914.5
申请日：2005-08-25
申请人： SCHERING CORPORATION
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0217
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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9.发明公开17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES 有权第17β-羟基TYPE 3用于治疗雄激素病抑制剂
公开(公告)号：EP1572299A1
公开(公告)日：2005-09-14
申请号：EP03790505.6
申请日：2003-12-15
申请人： SCHERING CORPORATION
发明人： GUZI, Timothy, J. , LIU, Yi-Tsung , DOLL, Ronald, J. , SAKSENA, Anil , GIRIJAVALLABHAN, Viyyoor, M. , PACHTER, Jonathan, A.
IPC分类号： A61P5/28 , A61P35/00 , A61K31/496 , A61K31/4545 , C07D401/14
CPC分类号： C07D401/14 , A61K31/435 , A61K31/495 , A61K31/56 , A61K45/06 , C07D211/16 , C07D241/04 , C07D241/08 , C07D401/04 , C07D401/06 , A61K2300/00
摘要： The present invention provides a novel class of compounds of formula (I): as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1337522A1
公开(公告)日：2003-08-27
申请号：EP01985496.7
申请日：2001-11-27
申请人： Schering Corporation
IPC分类号： C07D401/04 , C07D401/14 , A61K31/473 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
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