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公开(公告)号：EP1694659B8
公开(公告)日：2008-10-08
申请号：EP04814266.5
申请日：2004-12-16
发明人： BIJU, Purakkattle, J. , TAVERAS, Arthur, G. , YU, Younong , ZHENG, Junying , CHAO, Jianhua , AKI, Cynthia, J. , FINE, Jay , LUNDELL, Daniel , PRIESTLEY, Tony , REGGIANI, Angelo , MERRITT, J., Robert , BALDWIN, John, J.
IPC分类号： C07D285/10 , C07D417/12 , C07D417/14 , A61K31/433 , A61K31/4436
CPC分类号： C07D285/10 , C07D285/06 , C07D417/12 , C07D417/14
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公开(公告)号：EP2091534A1
公开(公告)日：2009-08-26
申请号：EP07838186.0
申请日：2007-09-13
申请人： Schering Corporation
发明人： ASLANIAN, Robert G. , CHAN, Tin-Yau , HARRIS, Joel M. , MCKITTRICK, Brian A. , NEUSTADT, Bernard R. , PALANI, Anandan , PRIESTLEY, Tony , SMITH, Elizabeth M. , STAMFORD, Andrew W. , VACCARO, Henry M. , XIAO, Dong
IPC分类号： A61K31/4427 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/28 , C07D401/04
CPC分类号： A61K31/4427 , C07D471/10 , C07D519/00
摘要： The present invention relates to methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering a compound having the formula (I) or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof, wherein: R1 and R2 are defined in Tables 1-6 herein, and R3 is -phenyl, -4-chlorophenyl, -2-pyridyl, or -3-pyridyl.
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3.发明公开
公开(公告)号：EP1697354A1
公开(公告)日：2006-09-06
申请号：EP04814856.3
申请日：2004-12-20
发明人： TAVERAS, Arthur, G. , ZHENG, Junying , BIJU, Purakkattle, J. , YU, Younong , CHAO, Jianhua , FINE, Jay , LUNDELL, Daniel , PRIESTLEY, Tony , REGGIANI, Angelo , MERRITT, J., Robert , BALDWIN, John, J. , LAI, Gaifa , WU, Minglang
IPC分类号： C07D417/12 , C07D275/02 , C07D417/14 , A61K31/427 , A61P35/00 , A61P29/00
CPC分类号： C07D275/03 , C07D417/12 , C07D417/14
摘要： Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.
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公开(公告)号：EP1694659B1
公开(公告)日：2008-08-27
申请号：EP04814266.5
申请日：2004-12-16
发明人： BIJU, Purakkattle, J. , TAVERAS, Arthur, G. , YU, Younong , ZHENG, Junying , CHAO, Jianhua , AKI, Cynthia, J. , FINE, Jay , LUNDELL, Daniel , PRIESTLEY, Tony , REGGIANI, Angelo , MERRITT, J., Robert , BALDWIN, John, J.
IPC分类号： C07D285/10 , C07D417/12 , C07D417/14 , A61K31/433 , A61K31/4436
CPC分类号： C07D285/10 , C07D285/06 , C07D417/12 , C07D417/14
摘要： Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).
摘要翻译： 公开了式（IA）的新化合物及其药学上可接受的盐和溶剂化物。 包含取代基A的基团的实例包括杂芳基，芳基，杂环烷基，环烷基，芳基，炔基，烯基，氨基烷基，烷基或氨基。 包含取代基B的基团的例子包括芳基和杂芳基。 还公开了治疗趋化因子介导的疾病例如癌症，血管生成，血管生成性眼病，肺部疾病，多发性硬化症，类风湿性关节炎，骨关节炎，中风和局部缺血再灌注损伤，疼痛（例如急性疼痛，急性和慢性 炎症性疼痛和神经性疼痛）使用式（IA）的化合物。
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5.发明公开COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF NAv1.8 审中-公开组合物和方法Nav1.8的短干扰，NUKLEINSÄUREINHIBITION
公开(公告)号：EP1809745A2
公开(公告)日：2007-07-25
申请号：EP05825147.1
申请日：2005-10-26
申请人： SCHERING CORPORATION , CANJI, Inc.
IPC分类号： C12N15/11 , A61K48/00 , C07K14/705 , A61P25/02 , C12N15/861
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
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公开(公告)号：EP1694659A1
公开(公告)日：2006-08-30
申请号：EP04814266.5
申请日：2004-12-16
发明人： BIJU, Purakkattle, J. , TAVERAS, Arthur, G. , YU, Younong , ZHENG, Junying , CHAO, Jianhua , AKI, Cynthia, J. , FINE, Jay , LUNDELL, Daniel , PRIESTLEY, Tony , REGGIANI, Angelo , MERRITT, J., Robert , BALDWIN, John, J.
IPC分类号： C07D285/10 , C07D417/12 , C07D417/14 , A61K31/433 , A61K31/4436
CPC分类号： C07D285/10 , C07D285/06 , C07D417/12 , C07D417/14
摘要： Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).
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