公开(公告)号：EP1694659B1

公开(公告)日：2008-08-27

申请号：EP04814266.5

申请日：2004-12-16

申请人： Schering Corporation ,  Pharmacopeia Drug Discovery, Inc.

发明人： BIJU, Purakkattle, J. ,  TAVERAS, Arthur, G. ,  YU, Younong ,  ZHENG, Junying ,  CHAO, Jianhua ,  AKI, Cynthia, J. ,  FINE, Jay ,  LUNDELL, Daniel ,  PRIESTLEY, Tony ,  REGGIANI, Angelo ,  MERRITT, J., Robert ,  BALDWIN, John, J.

IPC分类号： C07D285/10 ,  C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61K31/4436

CPC分类号： C07D285/10 ,  C07D285/06 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).

摘要翻译： 公开了式（IA）的新化合物及其药学上可接受的盐和溶剂化物。 包含取代基A的基团的实例包括杂芳基，芳基，杂环烷基，环烷基，芳基，炔基，烯基，氨基烷基，烷基或氨基。 包含取代基B的基团的例子包括芳基和杂芳基。 还公开了治疗趋化因子介导的疾病例如癌症，血管生成，血管生成性眼病，肺部疾病，多发性硬化症，类风湿性关节炎，骨关节炎，中风和局部缺血再灌注损伤，疼痛（例如急性疼痛，急性和慢性 炎症性疼痛和神经性疼痛）使用式（IA）的化合物。

公开(公告)号：EP1539678A1

公开(公告)日：2005-06-15

申请号：EP03772075.2

申请日：2003-07-30

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J. ,  CHAO, Jianping ,  DWYER, Michael ,  CHAO, Jianhua ,  YU, Younong ,  MERRITT, J., Robert ,  BIJU, Purakkattle ,  JAKWAY, James ,  LAI, Gaifa ,  WU, Minglang ,  HECKER, Evan, A. ,  LUNDELL, Daniel ,  FINE, Jay, S.

IPC分类号： C07C237/36 ,  C07C237/44 ,  C07C311/39 ,  C07D207/323 ,  C07D217/24 ,  C07D307/52 ,  C07D307/68 ,  C07D307/81 ,  C07D307/82 ,  C07D307/83 ,  C07D317/46 ,  C07D319/18 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381

CPC分类号： C07C237/30 ,  C07C225/20 ,  C07C237/36 ,  C07C237/44 ,  C07C255/59 ,  C07C311/39 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/335 ,  C07D213/74 ,  C07D217/24 ,  C07D295/26 ,  C07D307/38 ,  C07D307/52 ,  C07D307/68 ,  C07D307/81 ,  C07D307/82 ,  C07D307/83 ,  C07D317/46 ,  C07D319/18 ,  C07D333/20 ,  C07D333/36 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

摘要： Disclosed are novel compounds of the formula (I)or a pharmaceutically acceptable salt or solvate thereof. Also disclosed is the treatment of chemokine-mediated diseases using compounds of the formula (II)

摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的具有下式的化合物或其药学上可接受的盐或溶剂合物。

公开(公告)号：EP1381590B1

公开(公告)日：2007-06-20

申请号：EP02739172.1

申请日：2002-04-15

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J. ,  BOND, Richard, W. ,  CHAO, Jianping ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  CHAO, Jianhua ,  YU, Younong ,  BALDWIN, John, J. ,  KAISER, Bernd ,  LI, Ge ,  MERRITT, J., Robert ,  NELSON, Kingsley, H. ,  ROKOSZ, Laura, L.

IPC分类号： C07C237/30 ,  C07C255/59 ,  C07C225/20 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

CPC分类号： C07D231/38 ,  C07C225/20 ,  C07C237/30 ,  C07C255/59 ,  C07C2601/04 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

摘要： There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的具有下式的化合物或其药学上可接受的盐或溶剂合物。

公开(公告)号：EP1694659A1

公开(公告)日：2006-08-30

申请号：EP04814266.5

申请日：2004-12-16

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： BIJU, Purakkattle, J. ,  TAVERAS, Arthur, G. ,  YU, Younong ,  ZHENG, Junying ,  CHAO, Jianhua ,  AKI, Cynthia, J. ,  FINE, Jay ,  LUNDELL, Daniel ,  PRIESTLEY, Tony ,  REGGIANI, Angelo ,  MERRITT, J., Robert ,  BALDWIN, John, J.

IPC分类号： C07D285/10 ,  C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61K31/4436

CPC分类号： C07D285/10 ,  C07D285/06 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).

公开(公告)号：EP1697354A1

公开(公告)日：2006-09-06

申请号：EP04814856.3

申请日：2004-12-20

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： TAVERAS, Arthur, G. ,  ZHENG, Junying ,  BIJU, Purakkattle, J. ,  YU, Younong ,  CHAO, Jianhua ,  FINE, Jay ,  LUNDELL, Daniel ,  PRIESTLEY, Tony ,  REGGIANI, Angelo ,  MERRITT, J., Robert ,  BALDWIN, John, J. ,  LAI, Gaifa ,  WU, Minglang

IPC分类号： C07D417/12 ,  C07D275/02 ,  C07D417/14 ,  A61K31/427 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D275/03 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

公开(公告)号：EP1551818A1

公开(公告)日：2005-07-13

申请号：EP03781311.0

申请日：2003-10-07

申请人： Pharmacopeia Drug Discovery, Inc.

发明人： TAVERAS, Arthur, G. ,  CHAO, Jianhua ,  BIJU, Purakkattle, J. ,  YU, Younong ,  FINE, Jay, S. ,  HIPKIN, William ,  AKI, Cynthia, J. ,  MERRITT, J., Robert ,  LI, Ge ,  BALDWIN, John, J. ,  LAI, Gaifa ,  WU, Minglang ,  HECKER, Evan, A.

IPC分类号： C07D285/10 ,  C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61K31/4436

CPC分类号： C07D285/10 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

公开(公告)号：EP1434775A1

公开(公告)日：2004-07-07

申请号：EP02786395.0

申请日：2002-10-11

申请人： Schering Corporation ,  PHARMACOPEIA, INC.

发明人： TAVERAS, Arthur, G. ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  CHAO, Jianping ,  BALDWIN, John, J. ,  MERRITT, J., Robert ,  LI, Ge

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D207/44 ,  C07D401/08 ,  C07D403/12 ,  C07D401/12 ,  C07D409/14 ,  C07D417/12 ,  A61K31/4015 ,  A61K31/4025 ,  A61P35/00

CPC分类号： C07D207/456 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

公开(公告)号：EP1355875A1

公开(公告)日：2003-10-29

申请号：EP02731085.3

申请日：2002-02-01

申请人： SCHERING CORPORATION ,  PHARMACOPEIA, INC.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J., ,  BOND, Richard, W. ,  CHAO, Jianping ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  PACHTER, Jonathan ,  BALDWIN, John, J. ,  KAISER, Bernd ,  LI, Ge ,  MERRITT, J., Robert ,  NELSON, Kingsley, H., Jr. ,  ROKOSZ, Laura, L.

IPC分类号： C07C225/20 ,  C07C229/42 ,  C07C229/64 ,  C07C237/36 ,  C07C237/44 ,  C07C255/58 ,  C07C255/59 ,  C07C271/20 ,  C07C311/08 ,  C07C311/21 ,  C07D205/04 ,  C07D207/08 ,  C07D207/16 ,  C07D211/60 ,  C07D213/89 ,  C07D231/38 ,  C07D235/06 ,  C07D239/42 ,  C07D249/18 ,  C07D277/28 ,  C07D285/08

CPC分类号： C07D207/08 ,  C07C225/20 ,  C07C229/42 ,  C07C229/64 ,  C07C237/36 ,  C07C237/44 ,  C07C255/59 ,  C07C271/20 ,  C07C311/08 ,  C07C311/21 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D213/74 ,  C07D213/89 ,  C07D231/38 ,  C07D235/06 ,  C07D239/42 ,  C07D249/18 ,  C07D277/28 ,  C07D277/42 ,  C07D285/08 ,  C07D295/13 ,  C07D295/135 ,  C07D295/192 ,  C07D295/205 ,  C07D317/66 ,  C07D333/38

摘要： There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

摘要翻译： 公开了下式的化合物其前药，或所述化合物或所述前药的药学上可接受的盐，溶剂合物或异构体，其可用于治疗趋化因子介导的疾病，例如急性和慢性炎症性疾病和癌症。

公开(公告)号：EP1551818B1

公开(公告)日：2009-02-04

申请号：EP03781311.0

申请日：2003-10-07

申请人： Schering Corporation ,  Pharmacopeia, Inc.

发明人： TAVERAS, Arthur, G. ,  CHAO, Jianhua ,  BIJU, Purakkattle, J. ,  YU, Younong ,  FINE, Jay, S. ,  HIPKIN, William ,  AKI, Cynthia, J. ,  MERRITT, J., Robert ,  LI, Ge ,  BALDWIN, John, J. ,  LAI, Gaifa ,  WU, Minglang ,  HECKER, Evan, A.

IPC分类号： C07D285/10 ,  C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61K31/4436

CPC分类号： C07D285/10 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

公开(公告)号：EP1694659B8

公开(公告)日：2008-10-08

申请号：EP04814266.5

申请日：2004-12-16

申请人： Schering Corporation ,  Pharmacopeia, Inc.

发明人： BIJU, Purakkattle, J. ,  TAVERAS, Arthur, G. ,  YU, Younong ,  ZHENG, Junying ,  CHAO, Jianhua ,  AKI, Cynthia, J. ,  FINE, Jay ,  LUNDELL, Daniel ,  PRIESTLEY, Tony ,  REGGIANI, Angelo ,  MERRITT, J., Robert ,  BALDWIN, John, J.

IPC分类号： C07D285/10 ,  C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61K31/4436

CPC分类号： C07D285/10 ,  C07D285/06 ,  C07D417/12 ,  C07D417/14