公开(公告)号：EP1801204B1

公开(公告)日：2011-02-09

申请号：EP06026820.8

申请日：1995-08-09

申请人： Schering-Plough Ltd.

发明人： Wild, Martha ,  Junker, David E. ,  Cochran, Mark D. ,  Singer, Philip

IPC分类号： C12N5/10 ,  C12N5/20 ,  C12N7/01 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/24 ,  C12N15/26 ,  C12N15/27

CPC分类号： C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343

公开(公告)号：EP1801204A1

公开(公告)日：2007-06-27

申请号：EP06026820.8

申请日：1995-08-09

申请人： Schering-Plough Ltd.

发明人： Wild, Martha ,  Junker, David E. ,  Cochran, Mark D. ,  Singer, Philip

IPC分类号： C12N5/10 ,  C12N5/20 ,  C12N7/01 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/19 ,  C12N15/24 ,  C12N15/26 ,  C12N15/27

CPC分类号： C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343

摘要： This invention provides a recombinant herpesvirus of turkeys comprising a foreign DNA sequence encoding a cytokine inserted into an insertion region which comprises a Xhol site within an EcoR1 #9 fragment of a herpesvirus of turkeys viral genome, and the foreign DNA sequence encoding a cytokine which is capable of being expressed in a host cell infected with the herpesvirus of turkeys. This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short region. Lastly, this invention provides homology vectors for producing a recombinant herpesvirus of turkeys, host cells, and vaccines and methods for immunization.