公开(公告)号：EP2674413A1

公开(公告)日：2013-12-18

申请号：EP12172191.4

申请日：2012-06-15

申请人： SciPharm SàRL

发明人： Jain, Nareshkumar, F. ,  Kirkup, Michael, P. ,  Marella, Michael, A. ,  Ghone, Sanjeevani, A.

IPC分类号： C07C67/29 ,  C07C69/18 ,  C07F7/18 ,  C12P41/00

CPC分类号： C07C51/377 ,  C07C47/565 ,  C07C47/575 ,  C07C59/72 ,  C07C2603/14 ,  C07F7/18 ,  C07F7/1844 ,  C07F7/1852 ,  C07F7/1892 ,  C12P31/00 ,  C12P41/002 ,  C12P41/004

摘要： A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.

公开(公告)号：EP2674413B1

公开(公告)日：2017-06-07

申请号：EP12172191.4

申请日：2012-06-15

申请人： SciPharm SàRL

发明人： Jain, Nareshkumar, F. ,  Kirkup, Michael, P. ,  Marella, Michael, A. ,  Ghone, Sanjeevani, A.

IPC分类号： C07C67/29 ,  C07C69/18 ,  C07F7/18 ,  C12P41/00 ,  C07C47/565 ,  C07C47/575 ,  C07C51/377 ,  C07C59/72 ,  C12P31/00

CPC分类号： C07C51/377 ,  C07C47/565 ,  C07C47/575 ,  C07C59/72 ,  C07C2603/14 ,  C07F7/18 ,  C07F7/1844 ,  C07F7/1852 ,  C07F7/1892 ,  C12P31/00 ,  C12P41/002 ,  C12P41/004