公开(公告)号：EP1589960A1

公开(公告)日：2005-11-02

申请号：EP03813828.5

申请日：2003-12-18

申请人： Scios, Inc.

发明人： MEDICHERLA, Satyanarayana ,  PROTTER, Andrew, A. ,  SCHREINER, George, F.

IPC分类号： A61K31/155 ,  A61K31/415 ,  A61K31/445 ,  A61K31/505

CPC分类号： A61K31/445 ,  A61K31/00 ,  A61K31/155 ,  A61K31/415 ,  A61K31/505

摘要： The invention concerns the treatment obesity and associated conditions with TGF-β inhibitors. More specifically, the invention concerns the use of TGF-β inhibitors in the treatment of obesity, type 2 diabetes, and pathologic conditions associated with obesity or type 2 diabetes.

公开(公告)号：EP1140137A2

公开(公告)日：2001-10-10

申请号：EP99964277.0

申请日：1999-12-15

申请人： SCIOS INC.

发明人： STANTON, Lawrence, W. ,  WHITE, R., Tyler ,  DAMM, Deborah, L. ,  LEWICKI, John, A. ,  JOLY, Alison ,  SCHREINER, George, F.

IPC分类号： A61K38/17 ,  C07K14/47 ,  C12Q1/68 ,  A61K38/18 ,  C07K14/475 ,  C12N15/12

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods useful in the diagnosis, prevention and therapeutic treatment of a disease, specifically cardiac, kidney or inflammatory disease. Specifically, methods and compositions are provided for the diagnostic evaluation and prognosis of conditions involving a disease, specifically cardiac, kidney or inflammatory disease, for the identification of subjects exhibiting a predisposition to such conditions, for modulating the effect of these differentially expressed genes, for monitoring patients undergoing clinical evaluation for the prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and its disorders, and for monitoring the efficacy of compounds used in clinical trials.

公开(公告)号：EP1107959B1

公开(公告)日：2006-10-11

申请号：EP99949568.2

申请日：1999-08-27

申请人： SCIOS INC.

发明人： CHAKRAVARTY, Sarvajit ,  DUGAR, Sundeep ,  PERUMATTAM, John, J. ,  SCHREINER, George, F. ,  LIU, David, Y. ,  LEWICKI, John, A.

IPC分类号： C07D239/91 ,  C07D215/00 ,  C07D239/72 ,  A61P29/00 ,  A61K31/505 ,  A61K31/47

CPC分类号： C07D401/12 ,  A61K31/519 ,  C07D239/94 ,  C07D471/04

摘要： The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of formula (1) or the pharmaceutically acceptable salts thereof wherein R3 is a noninterfering substituent; each Z is CR2 or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N; each R2 is independently a noninterfering substituent; L is a linker; n is 0 or 1; and Ar' is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.

公开(公告)号：EP1575506A2

公开(公告)日：2005-09-21

申请号：EP03771821.0

申请日：2003-07-23

申请人： Scios, Inc.

发明人： LI, Zhihe ,  LIU, David, Y. ,  MA, Jing, Ying ,  PROTTER, Andrew ,  SCHREINER, George, F. ,  TRAN, Thomas-Toan

IPC分类号： A61K6/00

CPC分类号： A61K31/00 ,  A61K31/34 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4035 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5355

摘要： The invention concerns methods for improvement of lung function by administering non-peptide small molecule inhibitors of TGF-β specifically binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are quinazoline derivatives.

公开(公告)号：EP1572208A2

公开(公告)日：2005-09-14

申请号：EP03789956.4

申请日：2003-11-20

申请人： Scios, Inc.

发明人： FENG, Ying ,  HIGGINS, Linda, S. ,  KAPOUN, Ann, M. ,  LIU, David, Y. ,  SCHREINER, George, F.

IPC分类号： A61K31/495 ,  A61K31/50 ,  A61K31/505

CPC分类号： A61K31/495 ,  A61K31/50 ,  A61K31/505

摘要： The invention concerns methods for modulating the ß-adrenergic pathway. In particular, the invention concerns methods for counteracting a pathologic change, such as, for example, a loss in ß-adrenergic sensitivity, in the ß-adrenergic signal transduction pathway by administering an effective amount of a compound capable of inhibiting TGF-ß signaling through a TGF-ß receptor.

公开(公告)号：EP1511738A1

公开(公告)日：2005-03-09

申请号：EP03726892.7

申请日：2003-05-16

申请人： Scios Inc.

发明人： CHAKRAVARTY, Sarvajit ,  DUGAR, Sundeep ,  HIGGINS, Linda, S. ,  KAPOUN, Ann, M. ,  LIU, David, Y. ,  SCHREINER, George, F. ,  PROTTER, Andrew, A. ,  TRAN, Thomas-Toan

IPC分类号： C07D239/42 ,  C07D239/94 ,  C07D471/04

CPC分类号： A61K31/435 ,  A61K31/495 ,  A61K31/53

摘要： The invention concerns methods of treating fibroproliferative disorders associated with TGF-β signaling, by administering non-peptide small molecule inhibitors of TGF-β specifically binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are quinazoline derivatives. The invention also concerns methods for reversing the effect of TGF-β mediated cell activation on the expression of a gene associated with fibrosis, comprising contacting a cell or tissue in which the expression of such gene is altered as a result of TGF-β mediated cell activation, with a non-peptide small molecule inhibitor of TGF-β, specifically binding a TGFβ-R1 receptor kinase present in the cell or tissue.

公开(公告)号：EP1109571B1

公开(公告)日：2004-03-03

申请号：EP99968631.4

申请日：1999-09-09

申请人： SCIOS INC. ,  University of Washington

发明人： SCHREINER, George, F. ,  JOHNSON, Richard, J.

IPC分类号： A61K38/19 ,  A61K39/395 ,  A61P9/00 ,  G01N33/50

CPC分类号： A61K38/1866 ,  A61K48/00

摘要： The present invention provides methods and compositions for treating hypertension. The methods generally involve administering a factor which increases angiogenesis and/or vascular permeability. Compositions for use in the methods are also provided.

公开(公告)号：EP1112083A2

公开(公告)日：2001-07-04

申请号：EP99946776.4

申请日：1999-09-09

申请人： SCIOS INC.

发明人： SCHREINER, George, F. ,  JOHNSON, Richard, J.

IPC分类号： A61K38/19 ,  A61K48/00 ,  A61K39/395 ,  A61P9/00

CPC分类号： A61K38/1866 ,  A61K48/00

摘要： The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF).

公开(公告)号：EP1720562A1

公开(公告)日：2006-11-15

申请号：EP05705830.7

申请日：2005-01-18

申请人： Scios, Inc.

发明人： KAPOUN, Ann, M. ,  SCHREINER, George, F. ,  LIANG, Faquan ,  LI, Zhihe

IPC分类号： A61K38/00

CPC分类号： A61K38/2242

摘要： The invention concerns methods for treating cardiac remodeling in a subject who has undergone myocardial injury, said method comprising the administration of natriuretic peptide to said subject. Preferably the natriuretic peptide is brain natriuretic peptide. The invention also concerns methods for treating structural heart disorders arising from myocardial injury, said method comprising the administration of a natriuretic peptide to a patient in need thereof.

公开(公告)号：EP1490683A2

公开(公告)日：2004-12-29

申请号：EP03711618.3

申请日：2003-03-18

申请人： SCIOS INC.

发明人： SCHREINER, George, F.

IPC分类号： G01N33/543 ,  C07K1/00

CPC分类号： C07K14/58 ,  A61K38/2242 ,  A61K2300/00

摘要： Compositions and methods are disclosed for administration of synergistic levels of a diuretic and a natriuretic peptide, especially a recombinant form of human BNP, or hBNP. Theses compositions and methods are useful for the treatment of congestive heart failure.