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    IMMUNOLOGICAL MEASUREMENT REAGENT FOR USE IN MEASUREMENT OF KL-6
    2.
    发明公开
    IMMUNOLOGICAL MEASUREMENT REAGENT FOR USE IN MEASUREMENT OF KL-6 有权
    用于测量KL-6的免疫测定试剂

    公开(公告)号：EP2450709A1

    公开(公告)日：2012-05-09

    申请号：EP10794167.6

    申请日：2010-06-30

    申请人： Sekisui Medical Co., Ltd. ,  EIDIA Co., Ltd.

    发明人： KONDOU, Junichi ,  YAMAMOTO, Mitsuaki ,  KANEKO, Chie

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/6884 ,  G01N2333/4725 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/815

    摘要： The present invention aims to provide an assay reagent and an assay for accurately measuring KL-6, in particular, an assay reagent and an assay for accurately measuring KL-6 in samples containing a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor. KL-6 in samples that contain a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor can be accurately measured using an immunoassay reagent comprising a solution at a pH of 4.0 to 5.5 containing a rheumatoid factor interference inhibitor and a solution of an insoluble carrier on which anti-KL-6 antibodies are immobilized.

    摘要翻译： 本发明旨在提供用于准确测量KL-6的测定试剂和测定法，特别是用于准确测定含有类风湿因子和/或类风湿因子以外的非特异性物质的样品中的KL-6的测定法和测定法 因子。 含有类风湿因子和/或类风湿因子以外的非特异性物质的样品中的KL-6可以使用包含含有类风湿因子干扰抑制剂的pH4.0〜5.5的溶液的免疫测定试剂， 其上固定有抗KL-6抗体的不溶性载体。

    METHOD FOR INHIBITING NON-SPECIFIC REACTION IN PIVKA-II MEASUREMENT REAGENT
    3.
    发明公开
    METHOD FOR INHIBITING NON-SPECIFIC REACTION IN PIVKA-II MEASUREMENT REAGENT 审中-公开
    VERFAHREN ZUR HEMMUNG NICHTSPEZIFISCHER REAKENEN IN EINEM PIVKA-II-MESSREAGENZ

    公开(公告)号：EP2717054A1

    公开(公告)日：2014-04-09

    申请号：EP12789768.4

    申请日：2012-05-23

    申请人： Sekisui Medical Co., Ltd. ,  EIDIA Co., Ltd.

    发明人： MATSUMOTO, Takuji ,  YAMAMOTO, Mitsuaki

    IPC分类号： G01N33/543 ,  G01N33/53

    CPC分类号： G01N33/86 ,  G01N33/541 ,  G01N33/542 ,  G01N33/82

    摘要： A problem to be solved by the present invention is to inhibit a nonspecific agglutination reaction in an agglutination test using a monoclonal antibody having a property of specifically biding to PIVKA-II and a monoclonal antibody having a property of specifically biding to prothrombin as well as two types of carrier particles carrying these monoclonal antibodies. The nonspecific agglutination reaction can be inhibited by adding certain divalent metal ions to a reaction solution containing the monoclonal antibody having a property of specifically biding to PIVKA-II and the monoclonal antibody having a property of specifically biding to prothrombin as well as the two types of carrier particles carrying these monoclonal antibodies.

    摘要翻译： 本发明要解决的问题是使用具有特异性地与PIVKA-II特异性结合的单克隆抗体和具有特异性结合凝血酶原的特性的单克隆抗体以及两种具有特异性结合的单克隆抗体在凝集试验中抑制非特异性凝集反应 携带这些单克隆抗体的载体颗粒的类型。 通过向含有特异性地结合PIVKA-II的特性的单克隆抗体的反应溶液中添加某些二价金属离子，具有特异性结合凝血酶原的特性的单克隆抗体，也可以抑制两种非特异性凝集反应。 携带这些单克隆抗体的载体颗粒。

    GLYCATED HEMOGLOBIN (%) ASSAY METHOD
    4.
    发明公开
    GLYCATED HEMOGLOBIN (%) ASSAY METHOD 审中-公开

    公开(公告)号：EP3859332A1

    公开(公告)日：2021-08-04

    申请号：EP19865242.2

    申请日：2019-09-27

    申请人： Sekisui Medical Co., Ltd.

    发明人： OTA, Mieko ,  MIYAZAKI, Osamu ,  SEO, Satoko ,  YAMAMOTO, Mitsuaki ,  NISHIO, Tomohisa

    IPC分类号： G01N33/53 ,  G01N33/536

    摘要： A problem to be solved is to provide a glycated hemoglobin (%) assay method and assay reagent capable of accurate measurement of glycated hemoglobin (%) in blood even when a blood specimen containing hemoglobin contains abnormal hemoglobin such as HbS or HbC.
    The present invention provides a method capable of accurate measurement of glycated hemoglobin (%) in blood even in a specimen containing abnormal hemoglobin by combining two types of monoclonal antibodies, i.e., an anti-glycated hemoglobin monoclonal antibody and a monoclonal antibody to the anti-glycated hemoglobin monoclonal antibody, and an assay reagent for performing the method.

    L-FABP IMMUNOASSAY METHOD AND ASSAY REAGENT USED IN SAID METHOD
    6.
    发明公开
    L-FABP IMMUNOASSAY METHOD AND ASSAY REAGENT USED IN SAID METHOD 审中-公开
    所述方法中使用的L-FABP免疫测定方法和测定试剂

    公开(公告)号：EP3264083A1

    公开(公告)日：2018-01-03

    申请号：EP16755607.5

    申请日：2016-02-25

    申请人： Sekisui Medical Co., Ltd.

    发明人： KOBAYASHI, Koji ,  MATSUMOTO, Takuji ,  YAMAMOTO, Mitsuaki

    IPC分类号： G01N33/531 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/577 ,  C07C15/02 ,  G01N33/53 ,  G01N33/5306 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/54393 ,  G01N33/6893 ,  G01N33/92

    摘要： A problem to be solved by the invention is to provide an immunological measurement method for L-FABP in a sample using an anti-L-FABP antibody having a detection sensitivity equal to or greater than that of an existing pharmaceutical product for in-vitro diagnosis and having a favorable correlation. The problem is solved by a method of detecting L-FABP (liver-type fatty acid binding protein) in a sample with an anti-L-FABP antibody, comprising the step of bringing an anti-L-FABP antibody and a compound having a partial structure of NH 2 -C=N- and a cyclic structure in a molecule into contact with a sample suspected of containing L-FABP.

    摘要翻译： 本发明要解决的问题是提供使用检测灵敏度等于或大于现有用于体外诊断的药物产品的抗L-FABP抗体的样品中L-FABP的免疫学测量方法 并具有良好的相关性。 该问题通过用抗L-FABP抗体检测样品中的L-FABP（肝型脂肪酸结合蛋白）的方法来解决，该方法包括以下步骤：将抗L-FABP抗体和具有 NH 2 -C = N-的部分结构和分子中的环状结构与怀疑含有L-FABP的样品接触。

    INSULIN ASSAY METHOD
    7.
    发明公开
    INSULIN ASSAY METHOD 有权
    胰岛素测定方法

    公开(公告)号：EP2980586A1

    公开(公告)日：2016-02-03

    申请号：EP14775665.4

    申请日：2014-03-31

    申请人： Sekisui Medical Co., Ltd.

    发明人： KONDOU, Junichi ,  NIIYAMA, Kanami ,  YAMAMOTO, Mitsuaki

    IPC分类号： G01N33/53 ,  G01N33/531 ,  G01N33/543

    CPC分类号： G01N33/5306 ,  G01N33/54393 ,  G01N33/74 ,  G01N2333/62

    摘要： Provided herein is a human insulin latex agglutination immunoassay and assay reagents with which nonspecific reaction in a blood sample assay can be suppressed. The assay performs an immunoreaction with anti-insulin antibody-immobilized particles in a buffer containing two or more amine compounds having a pH buffering effect.

    摘要翻译： 本文提供了可以抑制血液样品测定中的非特异性反应的人胰岛素胶乳凝集免疫测定和测定试剂。 该试验在含有两种或更多种具有pH缓冲作用的胺化合物的缓冲液中与抗胰岛素抗体固定颗粒进行免疫反应。