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1.发明授权
公开(公告)号：EP0995435B1
公开(公告)日：2007-04-25
申请号：EP98917756.3
申请日：1998-04-30
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/32 , A61K47/38 , Y10S514/846 , Y10S514/912 , Y10S514/914 , Y10S514/937
摘要： A aqueous suspension preparations of hardly soluble drugs containing water soluble polymers at a concentration within a range from the concentration at which the decrease in the surface tension of the liquid preparations is initiated to the concentration at which such decrease is terminated. These preparations can be easily redispersed and undergo neither aggregation of the dispersed particles nor caking. The excellent redispersibility of these preparations makes them useful as injections, eye drops, nasal drops, drugs for internal use, lotions, etc.
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2.发明公开AQUEOUS SUSPENSION PREPARATIONS WITH EXCELLENT REDISPERSIBILITY 失效WÄSSRIGESUSPENSIONSPRÄPARATIONENMIT EXZELLENTERREDISPERSIBILITÄT
公开(公告)号：EP0995435A1
公开(公告)日：2000-04-26
申请号：EP98917756.3
申请日：1998-04-30
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/32 , A61K47/38 , Y10S514/846 , Y10S514/912 , Y10S514/914 , Y10S514/937
摘要： The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug begins to decrease up to the concentration at which the reduction in surface tension ceases. The resulting aqueous suspension shows ready redispersibility and will not undergo aggregation of dispersed particles or caking. Because of its good redispersibility, the suspension is useful as a parenteral preparation, eye drops, nasal drops, a preparation for oral administration, a lotion or the like.
摘要翻译： 含水悬浮液可以通过在难溶性药物的水性悬浮液中掺入水溶性聚合物来制备，所述水溶性聚合物的浓度范围是从药物的水性悬浮液的表面张力开始降低至浓度的浓度 表面张力下降停止。 所得水性悬浮液显示出可再分散性，并且不会发生分散的颗粒或结块的聚集。 由于其良好的再分散性，悬浮液可用作肠胃外制剂，滴眼剂，滴鼻剂，口服制剂，洗剂等。
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