公开(公告)号：EP1098648B1

公开(公告)日：2002-10-02

申请号：EP99937321.0

申请日：1999-07-19

申请人： SEPRACOR, INC.

发明人： YELLE, William, E.

IPC分类号： A61K31/4439 ,  A61P1/04 ,  A61P17/06

CPC分类号： A61K31/4439

摘要： Methods and compositions are disclosed utilizing hydroxylansoprazole for the treatment of ulcers in humans. Hydroxylansoprazole exhibits a lessened liability toward drug-drug interactions than lansoprazole and a more predictable dosing regimen than lansoprazole. Hydroxylansoprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1082114B1

公开(公告)日：2002-08-28

申请号：EP99922802.6

申请日：1999-05-05

申请人： SEPRACOR, INC.

发明人： YELLE, William, E. ,  HANDLEY, Dean, A.

IPC分类号： A61K31/4439 ,  A61K31/4184

CPC分类号： A61K31/4439 ,  A61K31/415 ,  Y10S514/926 ,  Y10S514/927

摘要： Methods and compositions are disclosed utilizing hydroxyomeprazole for the treatment of ulcers in humans. Hydroxyomeprazole exhibits a lessened liability toward drug-drug interactions than omeprazole and a more predictable dosing regimen than omeprazole. Hydroxyomeprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1075262B1

公开(公告)日：2005-08-10

申请号：EP99921682.3

申请日：1999-05-05

申请人： Sepracor Inc.

发明人： YELLE, William, E.

IPC分类号： A61K31/44 ,  A61K31/4439 ,  A61P1/04 ,  A61P17/06

CPC分类号： A61K31/4439

摘要： Methods and compositions are disclosed utilizing desmethylpantoprazole for the treatment of ulcers in humans. Desmethylpantoprazole exhibits a lessened liability toward drug-drug interactions than pantoprazole and a more predictable dosing regimen than pantoprazole. Desmethylpantoprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1171133A2

公开(公告)日：2002-01-16

申请号：EP00921896.7

申请日：2000-04-07

申请人： Sepracor Inc.

发明人： BARBERICH, Timothy, J. ,  RUBIN, Paul, D. ,  YELLE, William, E.

IPC分类号： A61K31/496 ,  A61P25/00 ,  A61P3/04 ,  A61P25/24 ,  A61P25/20 ,  A61P25/22 ,  A61P25/06

CPC分类号： A61K31/496 ,  C07D249/12

摘要： The R-isomer of the hydroxy metabolite of nefazodone, R-hydroxynefazodone, is an effective treatment for depression which does not give rise to the adverse effects associated with nefazodone. R-hydroxynefazodone is also useful in the treatment of migraine headaches, panic disorders, post traumatic stress disorder and sleep disorders.

公开(公告)号：EP1098648A1

公开(公告)日：2001-05-16

申请号：EP99937321.0

申请日：1999-07-19

申请人： SEPRACOR, INC.

发明人： YELLE, William, E.

IPC分类号： A61K31/44

CPC分类号： A61K31/4439

摘要： Methods and compositions are disclosed utilizing hydroxylansoprazole for the treatment of ulcers in humans. Hydroxylansoprazole exhibits a lessened liability toward drug-drug interactions than lansoprazole and a more predictable dosing regimen than lansoprazole. Hydroxylansoprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1135136B1

公开(公告)日：2003-11-05

申请号：EP99961750.9

申请日：1999-11-22

申请人： Sepracor Inc.

发明人： YELLE, William, E.

IPC分类号： A61K31/551 ,  A61P25/24 ,  A61P25/30 ,  A61P25/00 ,  A61P31/10 ,  A61P25/18 ,  A61P25/22 ,  A61P1/00

CPC分类号： A61K31/5513 ,  A61K31/551 ,  Y10S514/81 ,  Y10S514/811 ,  Y10S514/812

摘要： Methods and compositions are disclosed utilizing olanzapine-N-oxide for the treatment of psychosis in humans. Olanzapine-N-oxide exhibits a lessened liability toward drug-drug interactions than olanzapine and a more predictable dosing regimen than olanzapine. Olanzapine-N-oxide is also useful for the treatment of acute mania, mild anxiety states, anxiety disorders, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autistic disorder, excessive aggression, substance abuse, depressive signs and symptoms, tic disorder, functional bowel disorder and fungal dermatitis.

摘要翻译： 公开了利用奥氮平-N-氧化物治疗人类精神病的方法和组合物。 与奥氮平相比，奥氮平-N-氧化物对药物 - 药物相互作用的可靠性降低，并且可预测的剂量方案比奥氮平更可预测。 奥氮平N-氧化物也可用于治疗急性躁狂症，轻度焦虑症，焦虑症，精神分裂症，双相性精神障碍，注意力缺陷多动障碍，自闭症，过度攻击，药物滥用，抑郁症状和体征，抽动障碍，功能障碍 肠紊乱和真菌性皮炎。

公开(公告)号：EP1135136A1

公开(公告)日：2001-09-26

申请号：EP99961750.9

申请日：1999-11-22

申请人： Sepracor Inc.

发明人： YELLE, William, E.

IPC分类号： A61K31/551 ,  A61P25/24 ,  A61P25/30 ,  A61P25/00 ,  A61P31/10 ,  A61P25/18 ,  A61P25/22 ,  A61P1/00

CPC分类号： A61K31/5513 ,  A61K31/551 ,  Y10S514/81 ,  Y10S514/811 ,  Y10S514/812

摘要： Methods and compositions are disclosed utilizing olanzapine-N-oxide for the treatment of psychosis in humans. Olanzapine-N-oxide exhibits a lessened liability toward drug-drug interactions than olanzapine and a more predictable dosing regimen than olanzapine. Olanzapine-N-oxide is also useful for the treatment of acute mania, mild anxiety states, anxiety disorders, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autistic disorder, excessive aggression, substance abuse, depressive signs and symptoms, tic disorder, functional bowel disorder and fungal dermatitis.

公开(公告)号：EP1082114A1

公开(公告)日：2001-03-14

申请号：EP99922802.6

申请日：1999-05-05

申请人： SEPRACOR, INC.

发明人： YELLE, William, E. ,  HANDLEY, Dean, A.

IPC分类号： A61K31/415 ,  A61K31/44

CPC分类号： A61K31/4439 ,  A61K31/415 ,  Y10S514/926 ,  Y10S514/927

摘要： Methods and compositions are disclosed utilizing hydroxyomeprazole for the treatment of ulcers in humans. Hydroxyomeprazole exhibits a lessened liability toward drug-drug interactions than omeprazole and a more predictable dosing regimen than omeprazole. Hydroxyomeprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1075262A1

公开(公告)日：2001-02-14

申请号：EP99921682.3

申请日：1999-05-05

申请人： SEPRACOR, INC.

发明人： YELLE, William, E.

IPC分类号： A61K31/44

CPC分类号： A61K31/4439

摘要： Methods and compositions are disclosed utilizing desmethylpantoprazole for the treatment of ulcers in humans. Desmethylpantoprazole exhibits a lessened liability toward drug-drug interactions than pantoprazole and a more predictable dosing regimen than pantoprazole. Desmethylpantoprazole is also useful for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

公开(公告)号：EP1171133B1

公开(公告)日：2006-06-21

申请号：EP00921896.7

申请日：2000-04-07

申请人： Sepracor Inc.

发明人： BARBERICH, Timothy, J. ,  RUBIN, Paul, D. ,  YELLE, William, E.

IPC分类号： A61K31/496 ,  A61P25/24

CPC分类号： A61K31/496 ,  C07D249/12

摘要： The R-isomer of the hydroxy metabolite of nefazodone, R-hydroxynefazodone, is an effective treatment for depression which does not give rise to the adverse effects associated with nefazodone. R-hydroxynefazodone is also useful in the treatment of migraine headaches, panic disorders, post traumatic stress disorder and sleep disorders.

摘要翻译： 奈法唑酮羟基代谢物R-异构体R-羟基非唑酮是抑郁症的有效治疗药物，不会引起与奈法唑酮有关的副作用。 R-hydroxynefazodone也可用于治疗偏头痛，恐慌症，创伤后应激障碍和睡眠障碍。