利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.014 秒)

    BIOMARKERS AND METHODS FOR PREDICTING PREECLAMPSIA
    2.
    发明公开
    BIOMARKERS AND METHODS FOR PREDICTING PREECLAMPSIA 审中-公开
    生物标志物和用于预测先兆子痫

    公开(公告)号：EP2972393A2

    公开(公告)日：2016-01-20

    申请号：EP14762389.6

    申请日：2014-03-14

    申请人： Sera Prognostics, Inc.

    发明人： HICKOK, Durlin, Edward ,  BONIFACE, John, Jay ,  CRITCHFIELD, Gregory, Charles ,  FLEISCHER, Tracey, Cristine

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2800/368 ,  G06F19/18

    摘要： The disclosure provides biomarker panels, methods and kits for determining the probability for preeclampsia in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preeclampsia relative to matched controls. The present disclosure is further based, in part, on the unexepected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preeclampsia in a pregnant female with relatively high sensitivity and specificity. These proteins and peptides dislosed herein serve as biomarkers for classifying test samples, predicting a probability of preeclampsia, monitoring of progress of preeclampsia in a pregnant female, either individually or in a panel of biomarkers.

    BIOMARKER PAIRS FOR PREDICTING PRETERM BIRTH
    5.
    发明公开
    BIOMARKER PAIRS FOR PREDICTING PRETERM BIRTH 审中-公开

    公开(公告)号：EP4321626A2

    公开(公告)日：2024-02-14

    申请号：EP23193775.6

    申请日：2016-06-17

    申请人： Sera Prognostics, Inc.

    发明人： BONIFACE, John, Jay ,  FLEISCHER, Tracey ,  GASSMAN, Andrew ,  FLICK, Jeff ,  BRADFORD, Chad ,  POLPITIYA, Ashoka ,  HICKOK, Durlin, Edward ,  KEARNEY, Paul ,  CRITCHFIELD, Gregory, Charles

    IPC分类号： C12Q1/68

    摘要： The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAMl, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SFIBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAMl, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.