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    2-2'-Bis-thiazole derivatives as antiviral agents
    5.
    发明公开
    2-2'-Bis-thiazole derivatives as antiviral agents 有权
    2-2'-双噻唑衍生物抗病毒剂Wirkstoffe

    公开(公告)号：EP2218720A1

    公开(公告)日：2010-08-18

    申请号：EP10000847.3

    申请日：2006-01-24

    申请人： Shanghai Institute Of Materia Medica Chinese Academy of Sciences

    发明人： Nan, Fajun ,  Zuo, Jianping ,  Wang, Wenlong ,  Wang, Guifeng ,  Chen, Haijun ,  He, Peilan

    IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D403/04 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  A61K31/41 ,  A61K31/42 ,  A61K31/425

    CPC分类号： C07D277/56 ,  C07D277/68 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.

    摘要翻译： 本发明提供具有P1-P2结构式的串联的双杂环的小分子化合物及其用途以及含有这些化合物的组合物，P1和P2各自为不饱和5元杂环，其具有一个或两个 杂。 该化合物可有效抑制流感病毒的复制，乙型肝炎病毒（HBV）的DNA复制以及HBsAg和HBeAg的形成。 这些化合物可用于制备用于病毒性疾病的药物，并且可以克服已知的核苷类药物的限制，包括细胞毒性，对于长期诱导的抗药性病毒变体具有不同结构的其它药物的要求 治疗。 根据本发明的化合物的结构相对简单且易于制备。