公开(公告)号：EP4032890A1

公开(公告)日：2022-07-27

申请号：EP20866743.6

申请日：2020-09-21

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  China Pharmaceutical University

发明人： DUAN, Wenhu ,  GENG, Meiyu ,  ZHANG, Huibin ,  XIE, Zuoquan ,  ZHOU, Jinpei ,  YANG, Yifei ,  WANG, Xiyuan ,  YANG, Xiaojun ,  ZHANG, Yan ,  HU, Zhaoxue ,  DING, Jian

IPC分类号： C07D491/04 ,  A61K31/4184 ,  A61P35/00 ,  A61P31/00

摘要： Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.

公开(公告)号：EP4053124A1

公开(公告)日：2022-09-07

申请号：EP20881171.1

申请日：2020-10-23

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： DUAN, Wenhu ,  GENG, Meiyu ,  ZHAN, Zhengsheng ,  XIE, Zuoquan ,  ZHAO, Kaiyan ,  GUO, Yuting ,  WANG, Xiyuan ,  ZHANG, Yan ,  ZHOU, Xiaoqian ,  DING, Jian

IPC分类号： C07D409/04 ,  C07D409/14 ,  C07D407/04 ,  C07D333/00 ,  C07D231/56 ,  C07D493/00 ,  C07D487/00 ,  A61K31/381 ,  A61K31/403 ,  A61K31/343 ,  A61K31/357 ,  A61P35/00 ,  A61P37/00

摘要： The present invention relates to a five-membered heterocyclic oxocarboxylic acid compound and the medical use thereof. Specifically, the present invention relates to a compound as represented by formula (I) and a pharmaceutically acceptable salt, prodrug, hydrate, solvate or crystal form thereof, and also relates to a method for preparing the compound, a pharmaceutical composition containing the compound, and the medical use thereof as a secretion regulator of type I interferon, especially as a STING agonist, and in the preparation of a drug for preventing and/or treating diseases related to type I interferon.

公开(公告)号：EP3907221A1

公开(公告)日：2021-11-10

申请号：EP19907455.0

申请日：2019-12-31

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHANG, Ao ,  GENG, Meiyu ,  DING, Chunyong ,  XIE, Zuoquan ,  DING, Jian ,  ZHANG, Yan ,  SHEN, Ancheng ,  WANG, Xiyuan

IPC分类号： C07D333/60 ,  C07D333/58 ,  C07D333/56 ,  C07D409/12 ,  A61K31/381 ,  A61P35/00

摘要： The present invention relates to fluorine-containing substituted benzothiophene compound, and a pharmaceutical composition and an application thereof. Specifically, the compound of the present invention has the structure as shown in formula I, wherein the definitions of each group and substituent are as described in the description. The present invention further discloses a preparation method of the compound and an anti-tumor application thereof.