公开(公告)号：EP4279491A1

公开(公告)日：2023-11-22

申请号：EP22739024.2

申请日：2022-01-12

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  ZOU, Yang ,  ZHANG, Cili

IPC分类号： C07D501/46 ,  A61K31/546 ,  A61P31/04

摘要： The present disclosure relates to a cephalosporin antibacterial compound and a preparation method therefor. The cephalosporin antibacterial compound can exhibit antibacterial activity against Gram-negative bacteria and other bacteria.

公开(公告)号：EP4095141A1

公开(公告)日：2022-11-30

申请号：EP21745090.7

申请日：2021-01-22

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  ZOU, Yang ,  ZHANG, Cili

IPC分类号： C07D501/46 ,  A61K31/546 ,  A61P31/04

摘要： Provided are a cephalosporin compound represented by formula 1-1, 1-2, or 1-3, a pharmaceutical composition comprising same, and use thereof as an antibacterial agent.

公开(公告)号：EP3991730A1

公开(公告)日：2022-05-04

申请号：EP20831251.2

申请日：2020-06-28

申请人： Shanghai Shengdi Pharmaceutical Co., Ltd ,  Shanghai Senhui Medicine Co., Ltd. ,  Jiangsu Hengrui Medicine Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  ZOU, Yang ,  TANG, Yinggang

IPC分类号： A61K31/438 ,  C07D471/10 ,  A61P1/08 ,  A61P11/06 ,  A61P11/14 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24

摘要： A compound represented by formula II or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The compound represented by formula II is an antagonist of a neurokinin-1 receptor, can be used for treating diseases related to the neurokinin-1 receptor, and can avoid hemolytic effects of drugs and reduce the side effects of drug administration.

公开(公告)号：EP3805204A1

公开(公告)日：2021-04-14

申请号：EP19807109.4

申请日：2019-05-23

申请人： Suzhou Suncadia Biopharmaceuticals Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Medicine Co., Ltd.

发明人： LU, Gang ,  HUANG, Jian ,  HU, Yimin ,  ZHU, Lingjian ,  ZOU, Yang ,  CUI, Hua ,  YOU, Qidong ,  ZHANG, Xiaojin

IPC分类号： C07D213/81 ,  A61K31/44 ,  A61P9/10 ,  A61P7/06

摘要： Provided is a method for preparing an alkynyl pyridine prolyl hydroxylase inhibitor. In particular, the method involved uses 3-substituted-5-bromopyridine-2-carboxylic acid protected by different protection groups as raw materials, and by means of condensation, Sonogashira coupling and deprotection, the target compound is obtained. The process reaction conditions are simple, and have no harsh reaction conditions, strong operability, and stable amplification.