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公开(公告)号：EP4268818A1
公开(公告)日：2023-11-01
申请号：EP21909544.5
申请日：2021-12-24
申请人： Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Senhui Medicine Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： XU, Daping , YANG, Changyong , LIAO, Cheng , ZHANG, Lianshan , HUANG, Jian
IPC分类号： A61K31/438 , A61P1/08 , C07D471/10
摘要： The present disclosure relates to the use of an NK1 antagonist prodrug compound and a 5-HT3 receptor antagonist. In particular, the present disclosure relates to the use of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof in combination with a 5-HT3 receptor antagonist in the preparation of a drug for preventing or treating nausea and/or vomiting.
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公开(公告)号：EP4144742A1
公开(公告)日：2023-03-08
申请号：EP21796822.1
申请日：2021-04-30
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHANG, Lianshan , HUANG, Jian , ZHU, Lingjian , TANG, Yinggang , HUANG, Qi , MENG, Jia
IPC分类号： C07F9/09 , A61K31/683 , A61P9/14
摘要： Involved are an inositol derivative and a use thereof. Specifically, provided is a compound, said compound includes two or many parts, as represented by formula (D), connected via a common central linker L2, where formula (D) is as shown below.
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3.发明公开
公开(公告)号：EP4289857A1
公开(公告)日：2023-12-13
申请号：EP22749058.8
申请日：2022-01-28
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , HONG, Min , TANG, Manping , SU, Lu , DENG, Mengdie , ZHANG, Jingyang , REN, Wenming , LIN, Kan , HUANG, Jian , LIAO, Cheng , ZHANG, Lianshan
摘要： A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.
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公开(公告)号：EP3875475A1
公开(公告)日：2021-09-08
申请号：EP19898340.5
申请日：2019-12-20
申请人： Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd
发明人： CHEN, Lei , HU, Qiyue , GE, Hu , LIN, Yuan , WANG, Hongwei , OU, Yangchao , KONG, Xianglin , LIAO, Cheng , ZHANG, Lianshan
IPC分类号： C07K14/55 , C07K17/08 , C07K19/00 , C12N15/26 , C12N15/63 , C12P21/02 , A61K38/20 , A61K47/60 , A61K47/62 , A61K47/68 , A61P35/00 , A61P37/00
摘要： Provided is a human interleukin-2 (IL-2) variant having one or more amino acid mutations or a derivative thereof. The IL-2 variant or derivative thereof has increased stability compared to wild-type IL-2 and improved properties as an immunotherapeutic agent. Also disclosed are an immunoconjugate and a pharmaceutical composition which comprise the human IL-2 variant or derivative thereof, a polynucleotide molecule encoding same, a vector, a host cell and a preparation method therefor, as well as the pharmaceutical uses of the IL-2 variant or derivative thereof and the immunoconjugate or pharmaceutical composition comprising the L-2 variant or derivative thereof.
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公开(公告)号：EP4122493A1
公开(公告)日：2023-01-25
申请号：EP21770913.8
申请日：2021-03-19
发明人： ZHANG, Lianshan , ZHU, Bo , XIA, Jing
IPC分类号： A61K39/395 , A61P3/06 , C07K16/40 , A61K39/00
摘要： Provided in the present invention is a method for treating cholesterol-related diseases. In particular, in the present invention, an antibody combating proprotein convertase subtilisin/kexin Type 9 (PCSK9) or an antigen-binding fragment thereof is used to treat or prevent cholesterol-related diseases.
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