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    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END
    2.
    发明授权
    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END 有权

    公开(公告)号：EP3064524B1

    公开(公告)日：2018-09-12

    申请号：EP15197844.2

    申请日：2015-12-03

    申请人： Shin-Etsu Chemical Co., Ltd.

    发明人： SUKA, Yuki ,  HARADA, Yuji ,  WATANABE, Takeru ,  NONAKA, Shiori

    IPC分类号： C08G65/12 ,  C08G65/26 ,  C08G65/333 ,  C07C213/02 ,  C07C213/08 ,  C07F7/08 ,  C08G65/00 ,  C07F7/10

    CPC分类号： C07F7/0892 ,  C07C213/02 ,  C07C213/08 ,  C07F7/10 ,  C08G65/00 ,  C08G65/12 ,  C08G65/2609 ,  C08G65/33303 ,  C08G65/33306 ,  Y02P20/55 ,  C07C217/08

    摘要： A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR A 3 o(R A 4 O) k-1 R A 4 O - M + €ƒ€ƒ€ƒ€ƒ€ƒ(V) wherein R A 3 represents a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; R A 4 represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal; wherein R A 1a and R A 1b each independently represent a protective group of the amino group, or one of R A 1a and R A 1b represents H and the other represents a protective group of the amino group, or R A 1a and R A 1b bind to each other to form a cyclic protective group, and the protective group is deprotectable without using a heavy metal; R A 2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; and X represents a leaving group.

    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END
    3.
    发明公开
    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON POLYALKYLENGLYCOLDERIVAT MIT AMINO-ENDGRUPPE

    公开(公告)号：EP3064524A1

    公开(公告)日：2016-09-07

    申请号：EP15197844.2

    申请日：2015-12-03

    申请人： Shin-Etsu Chemical Co., Ltd.

    发明人： SUKA, Yuki ,  HARADA, Yuji ,  WATANABE, Takeru ,  NONAKA, Shiori

    IPC分类号： C08G65/12 ,  C08G65/26 ,  C08G65/333 ,  C07C213/02 ,  C07C213/08 ,  C07F7/08 ,  C08G65/00 ,  C07F7/10

    CPC分类号： C07F7/0892 ,  C07C213/02 ,  C07C213/08 ,  C07F7/10 ,  C08G65/00 ,  C08G65/12 ,  C08G65/2609 ,  C08G65/33303 ,  C08G65/33306 ,  Y02P20/55 ,  C07C217/08

    摘要： A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal:

            R A 3 o(R A 4 O) k-1 R A 4 O - M +      (V)

    wherein R A 3 represents a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; R A 4 represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal;

    wherein R A 1a and R A 1b each independently represent a protective group of the amino group, or one of R A 1a and R A 1b represents H and the other represents a protective group of the amino group, or R A 1a and R A 1b bind to each other to form a cyclic protective group, and the protective group is deprotectable without using a heavy metal; R A 2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; and X represents a leaving group.

    摘要翻译： 一种方法简单地生产在不使用重金属催化剂的情况下在末端具有氨基的窄分布和高纯度的聚亚烷基二醇衍生物。 通过使通式（V）表示的化合物与烯化氧反应，然后使反应产物与由通式（I）表示的亲电子试剂反应，以及将通式 不使用重金属对所得产品进行脱保护：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRA 3 o（RA 4 O）k-1 RA 4 O - M +€ƒ€ƒ€ （V）其中RA 3表示具有1至20个碳原子的直链，支链或环状烃基; R A 4表示碳原子数2〜8的亚烷基。 k表示2〜5的整数， M表示碱金属; 其中RA 1a和RA 1b各自独立地表示氨基的保护基，或者RA 1a和RA 1b之一表示H，另一个表示氨基的保护基，或者RA 1a和RA 1b彼此结合至 形成环状保护基，保护基在不使用重金属的情况下可脱保护; R A 2表示碳原子数为1〜6的直链状，支链状或环状的烃基。 X表示离去基团。

    BIOELECTRODE, PRODUCTION METHOD FOR BIOELECTRODE, AND MEASUREMENT METHOD FOR BIOSIGNALS
    4.
    发明公开
    BIOELECTRODE, PRODUCTION METHOD FOR BIOELECTRODE, AND MEASUREMENT METHOD FOR BIOSIGNALS 审中-公开

    公开(公告)号：EP4306558A1

    公开(公告)日：2024-01-17

    申请号：EP21930420.1

    申请日：2021-12-24

    申请人： SHIN-ETSU CHEMICAL CO., LTD.

    发明人： HATAKEYAMA, Jun ,  IWABUCHI, Motoaki ,  IKEDA, Joe ,  WATANABE, Osamu ,  NONAKA, Shiori ,  HASEGAWA, Koji

    IPC分类号： C08F212/14 ,  C08F220/38 ,  A61B5/25 ,  A61B5/266

    摘要： The present invention is a bio-electrode including a porous, stretchy base material, an adhesive, conductive film containing silicon, and a conducting path. The conductive film is formed on one surface of the porous, stretchy base material. The conducting path is connected to the conductive film, and penetrates the stretchy base material to be exposed on the opposite side. This enables provision of the bio-electrode that has high sensitivity to a bio-signal and excellent biocompatibility, that is lightweight, that can be produced at low cost, that is free of itching, red spots, and rash of the skin and comfortable even when being wet, dried, or attached to the skin for a long period of time, without a significant decrease in sensitivity to the bio-signal, a production method for the bio-electrode, and a measurement method for a bio-signa

    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END, POLYMERIZATION INITIATOR FOR USE IN THE SAME, AND ALCOHOL COMPOUND AS RAW MATERIAL FOR THE POLYMERIZATION INITIATOR
    7.
    发明公开
    METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END, POLYMERIZATION INITIATOR FOR USE IN THE SAME, AND ALCOHOL COMPOUND AS RAW MATERIAL FOR THE POLYMERIZATION INITIATOR 审中-公开
    用于生产POLYALKYLENGLYCOLDERIVATS与氨基末端基团，FOR USE聚合在其中并酒精相关的AS起始原料聚合

    公开(公告)号：EP3053944A1

    公开(公告)日：2016-08-10

    申请号：EP15197846.7

    申请日：2015-12-03

    申请人： Shin-Etsu Chemical Co., Ltd.

    发明人： SUKA, Yuki ,  HARADA, Yuji ,  WATANABE, Takeru ,  NONAKA, Shiori

    IPC分类号： C08G65/26 ,  C08G65/329 ,  C07F7/10

    CPC分类号： C07F7/10 ,  C08G65/2609 ,  C08G65/2618 ,  C08G65/2639 ,  C08G65/329 ,  Y02P20/55

    摘要： A method for producing a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end, a polymerization initiator for use in the method, and a precursor of the polymerization initiator are provided.
    The present invention provides: a method for producing a polyalkylene glycol derivative having an amino group at an end, using, as a polymerization initiator, a compound represented by the general formula (I); a compound represented by the following general formula (I); and a precursor thereof:

    wherein R A 1a and R A 1b each independently represent a protective group of the amino group, or one of R A 1a and R A 1b represents H and the other represents a protective group of the amino group, or R A 1a and R A 1b bind to each other to represent a cyclic protective group forming a ring; R A 2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; R A 3 represents a single bond, or a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms, and the hydrocarbon group may contain a heteroatom; the total number of carbon atoms (or the total number of carbon atoms and heteroatoms) of R A 2 and R A 3 is 4 or more; and M represents an alkali metal.

    摘要翻译： 一个窄分布和具有氨基的在端部的高纯度的聚亚烷基二醇衍生物中，提供了一种用于制造一种用于在所述方法中使用的聚合引发剂，和聚合引发剂的前体。 本发明提供：一种方法，用于生产聚亚烷基二醇衍生物具有氨基的在端部，使用作为聚合引发剂，由通式（I）表示的化合物; 由下述通式（I）表示的化合物; 和其前体：worin RA 1a和RA 1B各自unabhängig表示的保护基的氨基的，或RA 1a和RA 1B darstellt H，而另一个darstellt之一的保护基的氨基的，或RA 1a和RA 1B 结合到海誓山盟表示的环状保护基团形成一个环; R A 2表示直链，支链或环状烃具有1到6个碳原子基团; R A 3表示单键，或直链，支链或环状的烃基有1-20个碳原子，该烃基可以含有杂原子; 碳原子的R A 2和R A 3的总数目（或碳原子和杂原子的总数目）为4或更大; 碱金属的和M darstellt。

    METHODS OF PREPARING AND PURIFYING POLYALKYLENE GLYCOL DERIVATIVES
    9.
    发明公开
    METHODS OF PREPARING AND PURIFYING POLYALKYLENE GLYCOL DERIVATIVES 审中-公开

    公开(公告)号：EP3434713A1

    公开(公告)日：2019-01-30

    申请号：EP18185061.1

    申请日：2018-07-23

    申请人： Shin-Etsu Chemical Co., Ltd.

    发明人： NONAKA, Shiori ,  SUKA, Yuki ,  HARADA, Yuji

    IPC分类号： C08G65/26

    摘要： A polyalkylene glycol derivative with a minimal impurity content is prepared simply by the steps of reacting a compound having formula (III-I) or (III-II) with an electrophile having formula (IV) in the presence of an optional basic compound, to form a reaction solution containing a compound having formula (V), and passing the reaction solution through a column of cation and anion exchange resins to remove water-soluble impurities, for thereby purifying the desired polyalkylene glycol derivative.



             R 4 -R 5 -X     (IV)