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    NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
    2.
    发明公开
    NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY 有权
    蛋白酶抑制剂杂交细胞衍生物麻醉剂11BETA-羟肟酸脱氢酶TYP-1-HEMMUNGSAKTIVITÄT

    公开(公告)号：EP2163543A1

    公开(公告)日：2010-03-17

    申请号：EP08764258.3

    申请日：2008-05-07

    申请人： Shionogi&Co., Ltd.

    发明人： MASUDA, Koji ,  OGAWA, Tomoyuki ,  NAKATANI, Takuji

    IPC分类号： C07D231/14 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/5377 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P43/00 ,  C07D231/16 ,  C07D231/20 ,  C07D231/38 ,  C07D405/12

    CPC分类号： C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20 ,  C07D231/38 ,  C07D405/12 ,  C07D413/06

    摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.
    A compound represented by the formula:

    , its pharmaceutically acceptable salt, or a solvate thereof,
    wherein Ring A is a group represented by the formula:

    Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle,
    R 1 is hydrogen or optionally substituted alkyl,
    R 2 is -OR 5 , -SR 5 , halogen, halogenated alkyl or the like,
    R 3 is optionally substituted alkyl or the like,
    R 4 is optionally substituted alkyl or the like,
    R 5 is optionally substituted alkyl or the like,
    R 6 is hydrogen or the like,
    R 7 and R 8 are each independently hydrogen or the like,
    R 10 and R 11 are each independently hydrogen or the like,
    R 12 is optionally substituted alkyl or the like,
    m and p are each independently integer of 1 to 3.

    摘要翻译： 公开了可用作11β-羟基类固醇脱氢酶1型抑制剂的化合物。 由下式表示的化合物，其药学上可接受的盐或其溶剂化物，其中环A是由下式表示的基团：环B是任选取代的杂芳基，条件是排除任选取代的异唑或任选取代的杂环，R 1是氢或任选取代的烷基，R 2是-OR 5，-SR 5，卤素，卤代烷基等，R 3是任选取代的烷基等，R 4是任选取代的烷基等，R 5是 任选取代的烷基等，R 6为氢等，R 7和R 8各自独立地为氢等，R 10和R 11各自独立地为氢等，R 12为任选取代的烷基等 ，m和p各自独立地为1〜3的整数。