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    SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE AND PRODRUG THEREOF
    2.
    发明公开
    SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE AND PRODRUG THEREOF 审中-公开

    公开(公告)号：EP4219508A1

    公开(公告)日：2023-08-02

    申请号：EP23150186.7

    申请日：2016-04-27

    申请人： Shionogi & Co., Ltd

    发明人： KAWAI, Makoto ,  TOMITA, Kenji ,  AKIYAMA, Toshiyuki ,  OKANO, Azusa ,  MIYAGAWA, Masayoshi

    IPC分类号： C07D498/14 ,  A61P31/16 ,  A61K31/5383

    摘要： The present inventon provides the following compounds having anti-viral activity.

    A 1 is CR 1A R 1B , S or O;
    A 2 is CR 2A R 2B , S or O;
    A 3 is CR 3A R 3B , S or O;
    A 4 is CR 4A R 4B , S or O;
    the number of hetero atoms among atoms constituting the ring which consists of A 1 , A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 1 , is 1 or 2;
    R 1A and R 1B are each independently hydrogen, halogen, alkyl, or the like;
    R 2A and R 2B are each independently hydrogen, halogen, alkyl, or the like;
    R 3A and R 3B are each independently hydrogen, halogen, alkyl, or the like;
    R 4A and R 4B are each independently hydrogen, halogen, alkyl, or the like;
    R 3A and R 3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle;
    X is CH 2 , S or O;
    R 1 is each independently halogen, hydroxy, or the like;
    m is any integer of 0 to 2; and
    n is any integer of 1 to 2.

    SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE AND PRODRUG THEREOF
    7.
    发明公开
    SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE AND PRODRUG THEREOF 审中-公开
    取代的多环吡啶酮衍生物及其产物

    公开(公告)号：EP3290424A1

    公开(公告)日：2018-03-07

    申请号：EP16786500.5

    申请日：2016-04-27

    申请人： Shionogi & Co., Ltd

    发明人： KAWAI, Makoto ,  TOMITA, Kenji ,  AKIYAMA, Toshiyuki ,  OKANO, Azusa ,  MIYAGAWA, Masayoshi

    IPC分类号： C07D498/14 ,  C07D513/14 ,  C07D491/22 ,  C07D471/14 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/53 ,  A61P31/16

    CPC分类号： C07D498/14 ,  A61K31/53 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K31/675 ,  A61P31/16 ,  C07C2601/08 ,  C07C2601/16 ,  C07D471/14 ,  C07D471/20 ,  C07D491/22 ,  C07D513/14 ,  C07D519/00 ,  C07F7/1804 ,  C07F9/6561

    摘要： The present inventon provides the following compounds having anti-viral activity.

    A 1 is CR 1A R 1B , S or O;
    A 2 is CR 2A R 2B , S or O;
    A 3 is CR 3A R 3B , S or O;
    A 4 is CR 4A R 4B , S or O;
    the number of hetero atoms among atoms constituting the ring which consists of A 1 , A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 1 , is 1 or 2;
    R 1A and R 1B are each independently hydrogen, halogen, alkyl, or the like;
    R 2A and R 2B are each independently hydrogen, halogen, alkyl, or the like;
    R 3A and R 3B are each independently hydrogen, halogen, alkyl, or the like;
    R 4A and R 4B are each independently hydrogen, halogen, alkyl, or the like;
    R 3A and R 3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle;
    X is CH 2 , S or O;
    R 1 is each independently halogen, hydroxy, or the like;
    m is any integer of 0 to 2; and
    n is any integer of 1 to 2.

    摘要翻译： 本发明提供了具有抗病毒活性的下列化合物。 A1是CR1AR1B，S或O; A2是CR2AR2B，S或O; A3是CR3AR3B，S或O; A4是CR4AR4B，S或O; 构成由A1，A2，A3，A4，与A1相邻的氮原子和与A1相邻的碳原子构成的环的原子中的杂原子数为1或2; R1A和R1B各自独立地为氢，卤素，烷基等; R2A和R2B各自独立地为氢，卤素，烷基等; R3A和R3B各自独立地为氢，卤素，烷基等; R4A和R4B各自独立地为氢，卤素，烷基等; R3A和R3B可以一起形成非芳族碳环或非芳族杂环; X是CH2，S或O; R1各自独立地为卤素，羟基等; m是0至2的任何整数; 并且n是1至2的任何整数。

    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF
    8.
    发明公开
    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF 审中-公开

    公开(公告)号：EP4458348A2

    公开(公告)日：2024-11-06

    申请号：EP24190015.8

    申请日：2017-08-09

    申请人： Shionogi & Co., Ltd

    发明人： KAWAI, Makoto ,  TOMITA, Kenji ,  AKIYAMA, Toshiyuki ,  OKANO, Azusa ,  MIYAGAWA, Masayoshi

    IPC分类号： A61K9/06

    摘要： The present invention provides a pharmaceutical composition containing the following compound having antiviral action:

    P is hydrogen or a group to form a prodrug;
    A 1 is CR 1 A R 1 B , S or O;
    A 2 is CR 2 A R 2 B , S or O;
    A 3 is CR 3 A R 3 B , S or O;
    A 4 is each independently CR 4 A R 4 B , S or O;
    the number of hetero atoms among atoms constituting the ring which consists of A 1 ,
    A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 4 , is 1 or 2;
    R 1 A and R 1 B are each independently hydrogen, halogen, alkyl, or the like;
    R 2 A and R 2 B are each independently hydrogen, halogen, alkyl, or the like;
    R 3 A and R 3 B are each independently hydrogen, halogen, alkyl, or the like;
    R 4 A and R 4 B are each independently hydrogen, halogen, alkyl, or the like;
    R 3 A and R 3 B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle;
    R 1 is fluorine;
    m is any integer of 1 to 2; and
    n is any integer of 1 to 2.