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    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF
    1.
    发明公开
    PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF 审中-公开

    公开(公告)号：EP4458348A2

    公开(公告)日：2024-11-06

    申请号：EP24190015.8

    申请日：2017-08-09

    申请人： Shionogi & Co., Ltd

    发明人： KAWAI, Makoto ,  TOMITA, Kenji ,  AKIYAMA, Toshiyuki ,  OKANO, Azusa ,  MIYAGAWA, Masayoshi

    IPC分类号： A61K9/06

    摘要： The present invention provides a pharmaceutical composition containing the following compound having antiviral action:

    P is hydrogen or a group to form a prodrug;
    A 1 is CR 1 A R 1 B , S or O;
    A 2 is CR 2 A R 2 B , S or O;
    A 3 is CR 3 A R 3 B , S or O;
    A 4 is each independently CR 4 A R 4 B , S or O;
    the number of hetero atoms among atoms constituting the ring which consists of A 1 ,
    A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 4 , is 1 or 2;
    R 1 A and R 1 B are each independently hydrogen, halogen, alkyl, or the like;
    R 2 A and R 2 B are each independently hydrogen, halogen, alkyl, or the like;
    R 3 A and R 3 B are each independently hydrogen, halogen, alkyl, or the like;
    R 4 A and R 4 B are each independently hydrogen, halogen, alkyl, or the like;
    R 3 A and R 3 B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle;
    R 1 is fluorine;
    m is any integer of 1 to 2; and
    n is any integer of 1 to 2.

    AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY
    8.
    发明公开
    AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY 审中-公开

    公开(公告)号：EP4238960A8

    公开(公告)日：2023-11-22

    申请号：EP21886259.7

    申请日：2021-10-27

    申请人： Shionogi & Co., Ltd. ,  UBE Corporation

    发明人： OKANO, Azusa ,  TATENO, Yusuke ,  NODU, Kouhei ,  SUZUKI, Shinji ,  AKIYAMA, Toshiyuki ,  MATOYAMA, Masaaki ,  AKAZA, Hiroto ,  FUKUDA, Takashi

    IPC分类号： C07D20060101

    摘要： The present invention provides a compound represented by formula (I) :

    wherein the dashed line indicates the presence or absence of a bond; R 1 is carboxy or the like; L is substituted or unsubstituted non-aromatic carbocyclyldiyl or the like; R 2 is substituted or unsubstituted alkyl; R 3 is a hydrogen atom or the like; X is =CR X -or =N-; Y is =CR Y - or =N-; U is -CR U = or -N=; V is -CR V = or -N=; W is =CR W - or =N-; Z A is -C= or -N-; Z B is -CR 5 R 6 - or the like; Z C is -CR 7 R 8 - or the like; R X , R Y , R V and R W are each independently a hydrogen atom or the like; R U is a hydrogen atom or the like; R 5 and R 6 are each independently a hydrogen atom or the like; R 7 and R 8 are each independently a hydrogen atom or the like; R 4 is substituted or unsubstituted alkyloxy or the like,
    or a pharmaceutically acceptable salt thereof, having an antiviral activity; and a pharmaceutical composition comprising the same.

    AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY
    9.
    发明公开
    AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY 审中-公开

    公开(公告)号：EP4238960A1

    公开(公告)日：2023-09-06

    申请号：EP21886259.7

    申请日：2021-10-27

    申请人： Shionogi & Co., Ltd ,  UBE Corporation

    发明人： OKANO, Azusa ,  TATENO, Yusuke ,  NODU, Kouhei ,  SUZUKI, Shinji ,  AKIYAMA, Toshiyuki ,  MATOYAMA, Masaaki ,  AKAZA, Hiroto ,  FUKUDA, Takashi

    IPC分类号： C07D20060101

    摘要： The present invention provides a compound represented by formula (I) :

    wherein the dashed line indicates the presence or absence of a bond; R 1 is carboxy or the like; L is substituted or unsubstituted non-aromatic carbocyclyldiyl or the like; R 2 is substituted or unsubstituted alkyl; R 3 is a hydrogen atom or the like; X is =CR X -or =N-; Y is =CR Y - or =N-; U is -CR U = or -N=; V is -CR V = or -N=; W is =CR W - or =N-; Z A is -C= or -N-; Z B is -CR 5 R 6 - or the like; Z C is -CR 7 R 8 - or the like; R X , R Y , R V and R W are each independently a hydrogen atom or the like; R U is a hydrogen atom or the like; R 5 and R 6 are each independently a hydrogen atom or the like; R 7 and R 8 are each independently a hydrogen atom or the like; R 4 is substituted or unsubstituted alkyloxy or the like,
    or a pharmaceutically acceptable salt thereof, having an antiviral activity; and a pharmaceutical composition comprising the same.