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1.发明公开CELL CLUSTER COMPRISING PLURAL KINDS OF CELLS DERIVED FROM SOMA WITH ABILITY TO FORM PRIMITIVE ORGAN-LIKE STRUCTURE 有权CELL CLUSTER MT多种细胞类型，从SOMA与能力，形成原始的器官样结构
公开(公告)号：EP2034011A1
公开(公告)日：2009-03-11
申请号：EP07768103.9
申请日：2007-06-27
CPC分类号： C12N5/0697 , C12N5/0625 , C12N5/0627 , C12N5/0629 , C12N5/0666 , C12N2501/40 , C12N2501/415
摘要： The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.
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2.发明授权CELL MASS CAPABLE OF SERVING AS A PRIMITIVE ORGAN-LIKE STRUCTURE COMPRISED OF A PLURALITY OF CELL TYPES OF SOMATIC ORIGIN 有权细胞质能够作为包含多种细胞类型的体细胞起源的原始类似器官的结构
公开(公告)号：EP2455111B1
公开(公告)日：2017-08-16
申请号：EP12155498.4
申请日：2007-06-27
IPC分类号： C12N5/077 , C12N5/071 , C12N5/0775 , A61L27/00
CPC分类号： C12N5/0697 , C12N5/0625 , C12N5/0627 , C12N5/0629 , C12N5/0666 , C12N2501/40 , C12N2501/415
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3.发明授权CELL CLUSTER COMPRISING PLURAL KINDS OF CELLS DERIVED FROM SOMA WITH ABILITY TO FORM PRIMITIVE ORGAN-LIKE STRUCTURE 有权ZELLCLUSTER MT MEHREREN ZELLARTEN AUS DEM SOMA MITFÄHIGKEITZUR BILDUNG PRIMITIVERORGANÄHNLICHERSTRUKTUREN
公开(公告)号：EP2034011B1
公开(公告)日：2013-05-22
申请号：EP07768103.9
申请日：2007-06-27
IPC分类号： C12N5/0775 , C12N5/071 , A61L27/00
CPC分类号： C12N5/0697 , C12N5/0625 , C12N5/0627 , C12N5/0629 , C12N5/0666 , C12N2501/40 , C12N2501/415
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4.发明公开METHOD OF PREDICTING SKIN SPOT FORMATION AND METHOD OF SCREENING SKIN SPOT FORMATION INHIBITOR WITH THE USE OF SPOT SITE-INCREASING GENES AS INDICATION 审中-公开一种用于预测皮肤丘疹的筛选抑制剂皮肤疙瘩教育的形成和模式使用指向疙瘩放大基因，指标
公开(公告)号：EP2011883A1
公开(公告)日：2009-01-07
申请号：EP07742776.3
申请日：2007-04-24
发明人： AOKI, Hirofumi , KISHIMOTO, Jiro , MORO, Osamu
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5088
摘要： The present invention provides a skin test method for predicting the formation of spots in the skin. This method is characterized by judging skin to be susceptible to spot formation in the case expression of genes consisting of MLSTD1, MOGAT1, FADS2, FADS1, HSD3B1, ELOVL3, BG1, PECR, FABP7, FA2H, HAO2, ALOX15B, PDE6A, LZTS1, SEC14L4, BAMBI, CIDEA, TERE1, GAL, THRSP, INSIG1 or CUTL2 in the epidermis is accelerated, or the expression of genes consisting of RBBP6, MSMB, WIF1, ANKRD12, FLG, SYNE2, SCEL, NKTR or AMBP in the epidermis is decreased as compared with normal expression in the epidermis.
摘要翻译： 本发明提供用于预知皮肤斑形成的皮肤检查方法。 这种方法是通过判断皮肤易受在基因由......组成MLSTD1，MOGAT1，FADS2 FADS1，HSD3B1，ELOVL3，BG1，PECR，FABP7，FA2H，HAO2，ALOX15B，PDE6A，LZTS1，SEC14L4的情况下表达点形成为特征的 ，BAMBI，CIDEA，TERE1，GAL，THRSP，INSIG1或CUTL2在表皮被加速，或基因在表皮RBBP6，MSMB，WIF1，ANKRD12，FLG，SYNE2，SCEL，NKTR或AMBP由......组成的减小作为表达 与在表皮正常表达进行比较。
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公开(公告)号：EP1067968B1
公开(公告)日：2007-02-28
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
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公开(公告)号：EP1067968A1
公开(公告)日：2001-01-17
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
摘要翻译： 本发明提供了评估治疗对皮肤作用的方法。 本发明还提供了具有与皮肤代谢启动子偶联的报道基因的非人转基因动物，例如小鼠。
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