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公开(公告)号:EP3998265A1
公开(公告)日:2022-05-18
申请号:EP20840300.6
申请日:2020-07-10
发明人: LIU, Zhihua , YUAN, Dechuang , CHEN, Kuncheng , YUAN, Baokun , REN, Ren , MIN, Wangyang , LIU, Xijie , ZHANG, Kai , SUN, Yongliang , LU, Chang , SUN, Yinghui
IPC分类号: C07D471/04 , C07D519/00 , A61P35/00 , A61K31/496 , A61K31/4995 , A61K31/55 , A61K31/497
摘要: The present invention provides an RET selective inhibitor and preparation method and use thereof; the present invention provides a compound of formula (I) and a pharmaceutically accepted salt, solvate, polymorph, or tautomer thereof, a composition comprising these compounds, and use of these compounds in the treatment of diseases related to RET.
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公开(公告)号:EP3936509A1
公开(公告)日:2022-01-12
申请号:EP20771072.4
申请日:2020-03-06
发明人: WANG, Jinghan , YAO, Jinsuo , DUAN, Xiaowei , YUAN, Baokun , LIU, Xijie , JIAO, Nan , MIN, Wangyang , SUN, Ying , LU, Chang , SUN, Yinghui , ZHANG, Jiuqing , JI, Yeling , HOU, Deng
IPC分类号: C07D519/00 , C07D471/14 , A61K31/438 , A61K31/4995 , A61K31/4375 , A61K31/496 , A61K31/499 , A61K31/5386 , A61K31/5377 , A61K31/541 , A61P35/00
摘要: The invention relates to an FGFR4 kinase inhibitor, and the preparation method and use thereof. The invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, solvate, polymorph or tautomer thereof, and use thereof in the manufacture of a medicament for the treatment of an FGFR4 mediated disease.
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