-
公开(公告)号：EP4327875A3
公开(公告)日：2024-05-22
申请号：EP23210115.4
申请日：2019-04-25
发明人： WEI, Lai
CPC分类号： C12N1/20 , C12Q1/025 , A61K49/0008 , A61K31/43 , A61K31/7036 , A61K31/4164 , A61K31/65 , G01N33/5088 , G01N2800/1620130101 , G01N2500/1020130101 , A61K35/742 , A61K35/747 , A61K35/744 , A61K2035/11520130101 , Y02A50/30 , C12Q1/18
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD). For example, provided herein are screening methods for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. The screening method can be an in vitro screening method or an in vivo screening method, e.g., using an animal model described herein. Animal models are also provided herein, for example, for screening candidate therapeutics for treating or preventing eye diseases, such as AMD. Methods of preparing the animal models are also described herein. Methods of treating or preventing AMD are also provided.
-
2.发明公开
公开(公告)号：EP4353315A3
公开(公告)日：2024-05-15
申请号：EP23215639.8
申请日：2019-11-12
发明人： ZHANG, Yan , WEI, Lai , OUYANG, Hui
IPC分类号： A61K31/43 , A61P27/02 , A61K31/4164 , A61K31/65 , A61K31/7036 , A61K38/14 , A61K45/06 , A61P31/04 , A01K67/02 , C12Q1/18
CPC分类号： A61P31/00 , A61P27/02 , C12Q1/18 , G01N2800/1620130101 , A61K49/0008 , A61K31/12 , A61K31/4745 , A61K31/085 , A61K31/216 , A61K31/7034 , A61K31/43 , A61K31/7036 , A61K31/65 , A61K31/4164 , A61K38/14 , A61K45/06 , A61P31/04
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
-
公开(公告)号：EP4382112A1
公开(公告)日：2024-06-12
申请号：EP22866419.9
申请日：2022-08-24
发明人： WEI, Lai
摘要： Provided is a method for building an eye disease model, comprising infecting microorganisms onto a model carrier. Also provided is an eye model carrier infected with microorganisms prepared using said method. The eye model carrier can be used for eye disease research and eye disease drug screening. The eye disease refers to retinal degeneration and the microorganisms refer to intestinal bacteria or bacteria identical to the intestinal bacteria.
-
4.发明公开
公开(公告)号：EP4353315A2
公开(公告)日：2024-04-17
申请号：EP23215639.8
申请日：2019-11-12
发明人： ZHANG, Yan , WEI, Lai , OUYANG, Hui
IPC分类号： A61P27/02
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
-
公开(公告)号：EP4382103A1
公开(公告)日：2024-06-12
申请号：EP22866420.7
申请日：2022-08-24
发明人： WEI, Lai
IPC分类号： A61K31/437 , A61K31/122 , A61K31/05 , A61K36/00 , A61P27/02
CPC分类号： A61K31/437 , A61K36/00 , A61P27/02 , A61K31/05 , A61K31/122
摘要： The present disclosure provides a treatment method for retinal degeneration. The method includes administering an inhibitor or microbicid for a microorganism to eyes or a gastrointestinal tract of a patient. Specifically, the present disclosure proves that the inhibitor or microbicid may be used as a drug for treating a retinal degeneration disease by establishing an eye disease model or an eye disease model carrier, especially, a retinal degeneration model or model carrier.
-
公开(公告)号：EP4327875A2
公开(公告)日：2024-02-28
申请号：EP23210115.4
申请日：2019-04-25
发明人： WEI, Lai
IPC分类号： A61P27/02
摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD). For example, provided herein are screening methods for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. The screening method can be an in vitro screening method or an in vivo screening method, e.g., using an animal model described herein. Animal models are also provided herein, for example, for screening candidate therapeutics for treating or preventing eye diseases, such as AMD. Methods of preparing the animal models are also described herein. Methods of treating or preventing AMD are also provided.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.011 秒)
