公开(公告)号：EP1223944B1

公开(公告)日：2007-01-03

申请号：EP00965329.6

申请日：2000-09-22

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： DUFFY, Kevin, J. ,  LUENGO, Juan, I. ,  LIU, Nannan

IPC分类号： A61K31/655 ,  C07D401/14 ,  C07D403/12

CPC分类号： C07D401/14 ,  C07D231/48

摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected azo-pyrazole derivative.

公开(公告)号：EP1294378B1

公开(公告)日：2007-10-03

申请号：EP01941599.1

申请日：2001-05-24

申请人： SMITHKLINE BEECHAM CORPORATION

发明人： DUFFY, Kevin, J. ,  ERICKSON-MILLER, Connie, L. ,  EPPLEY, Daniel, F. ,  JENKINS, Julian ,  LUENGO, Juan, I. ,  LIU, Nannan ,  PRICE, Alan, T. ,  SHAW, Antony, N. ,  VISONNEAU, Sophie ,  WIGGALL, Kenneth

IPC分类号： C07D417/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  A61K31/4439 ,  A61K31/415 ,  A61K31/506

CPC分类号： C07D403/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  C07D417/12

摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

公开(公告)号：EP1294378A2

公开(公告)日：2003-03-26

申请号：EP01941599.1

申请日：2001-05-24

申请人： SMITHKLINE BEECHAM CORPORATION ,  GLAXO GROUP LIMITED

发明人： DUFFY, Kevin, J. ,  ERICKSON-MILLER, Connie, L. ,  EPPLEY, Daniel, F. ,  JENKINS, Julian ,  LUENGO, Juan, I. ,  LIU, Nannan ,  PRICE, Alan, T. ,  SHAW, Antony, N. ,  VISONNEAU, Sophie ,  WIGGALL, Kenneth

IPC分类号： A61K31/41 ,  A61K31/4152 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/655 ,  C07D213/79 ,  C07D231/20 ,  C07D257/04 ,  C07D401/02 ,  C07D403/02 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D403/12 ,  C07D231/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04 ,  C07D417/12

摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备目前发明的化合物的新型方法和中间体。 还发明了一种治疗需要治疗的哺乳动物包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的羟基-1-偶氮苯衍生物。

公开(公告)号：EP1223944A1

公开(公告)日：2002-07-24

申请号：EP00965329.6

申请日：2000-09-22

申请人： SmithKline Beecham Corporation

发明人： DUFFY, Kevin, J. ,  LUENGO, Juan, I. ,  LIU, Nannan

IPC分类号： A61K31/655 ,  C07D231/22 ,  C07D231/26 ,  C07D231/38

CPC分类号： C07D401/14 ,  C07D231/48

摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected azo-pyrazole derivative.

摘要翻译： 发明的是非肽TPO模拟物。 还发明了一种治疗有需要的哺乳动物包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的偶氮 - 吡唑衍生物。