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1.发明公开MEDICINE, FOOD AND DRINK OR FEED CONTAINING SPHINGOMYELIN 有权SPHINGOMYELIN ENTHALTENDE MEDIZIN，NAHRUNGSMITTEL UNDGETRÄNK
公开(公告)号：EP1938824A1
公开(公告)日：2008-07-02
申请号：EP06810466.0
申请日：2006-09-22
发明人： KATO, Ken , MIURA, Susumu , TANAKA, Leo , UENO, Hiroshi , UEDA, Noriko , HARUTA, Yuko , YOSHIOKA, Toshimitsu
IPC分类号： A61K31/688 , A23K1/16 , A23L1/30 , A61K8/68 , A61K35/20 , A61P1/00 , A61P17/00 , A61P17/14 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P37/08 , A61P39/06 , A61Q7/00 , A61Q19/02
CPC分类号： A61K31/688 , A23K20/158 , A23K50/40 , A23K50/48 , A23L2/52 , A23L33/10 , A23L33/12 , A23V2002/00 , A61K8/68 , A61Q7/00 , A61Q19/02 , C07F9/10 , A23V2250/21 , A23V2200/304 , A23V2200/32
摘要： It is intended to find novel pharmaceutical use of sphingomyelin and to provide preventive or therapeutic agents for various diseases as well as a food and drink product and feed comprising any of these agents. The present invention provides a pharmaceutical agent which contains sphingomyelin as an active ingredient and is any of the following agents: 1) a sialomucin secretion promoter, 2) an agent for preventing drunken sickness (hangover), 3) an antiallergic agent, 4) an antioxidant, 5) an agent for defending against infection, 6) a hair growth agent, 7) a therapeutic agent for demyelinating disease, 8) an anti-pigmentation agent, 9) an anti-inflammatory agent, and 10) an agent for improving learning ability. The present invention also provides a food and drink product or feed, characterized by comprising the agent. It is preferred that the sphingomyelin should be derived from milk.
摘要翻译： 旨在找到鞘磷脂的新药用途，并提供各种疾病的预防或治疗剂，以及包含任何这些药剂的食品和饮料产品和饲料。 本发明提供含有鞘磷脂作为活性成分的药剂，其为以下药剂：1）唾液酸粘蛋白分泌促进剂，2）防止酒醉（宿醉）的药剂，3）抗过敏剂，4） 抗氧化剂，5）防止感染的药剂，6）毛发生长剂，7）脱髓鞘疾病的治疗剂，8）抗色素沉着剂，9）抗炎剂，和10）改善剂 学习能力 本发明还提供一种食品和饮料产品或饲料，其特征在于包含该试剂。 鞘磷脂优选来源于牛奶。
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公开(公告)号：EP1938824B1
公开(公告)日：2011-11-30
申请号：EP06810466.0
申请日：2006-09-22
发明人： KATO, Ken , MIURA, Susumu , TANAKA, Leo , UENO, Hiroshi , UEDA, Noriko , HARUTA, Yuko , YOSHIOKA, Toshimitsu
IPC分类号： A61K31/688 , A23K1/16 , A23L1/30 , A61K8/68 , A61K35/20 , A61P1/00 , A61P17/00 , A61P17/14 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P37/08 , A61P39/06 , A61Q7/00 , A61Q19/02
CPC分类号： A61K31/688 , A23K20/158 , A23K50/40 , A23K50/48 , A23L2/52 , A23L33/10 , A23L33/12 , A23V2002/00 , A61K8/68 , A61Q7/00 , A61Q19/02 , C07F9/10 , A23V2250/21 , A23V2200/304 , A23V2200/32
摘要： It is intended to find a novel medicinal application of sphingomyelin and to provide a preventive agent or a therapeutic agent for various diseases and a food and drink and feed containing the agent. A medicine which contains sphingomyelin as an active ingredient and is any of the following agents: 1) a sialomucin secretion promoter, 2) an agent for preventing getting sick from drinking, 3) an antiallergic agent, 4) an antioxidant, 5) an agent for preventing infection, 6) a hair growth agent, 7) a therapeutic agent for a demyelinating disease, 8) an anti-pigmentation agent, 9) an antiinflammatory agent or 10) an agent for improving learning ability. The food and drink or the feed is characterized by comprising the agent. The sphingomyelin is preferably derived from milk.
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公开(公告)号：EP2156820A1
公开(公告)日：2010-02-24
申请号：EP08764523.0
申请日：2008-05-22
发明人： WATANABE, Tatsuya , KATO, Ken , UENO, Hiroshi , HARUTA, Yuko , UEDA, Noriko , YOSHIOKA, Toshimitsu
IPC分类号： A61K8/64 , A23K1/16 , A23K1/175 , A23L1/30 , A23L1/305 , A23L2/52 , A61K8/19 , A61K8/26 , A61K8/27 , A61K9/08 , A61K33/06 , A61K33/10 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K38/16 , A61P17/00 , A61Q19/02
CPC分类号： A61K33/34 , A23K20/105 , A23K20/147 , A23K20/20 , A23K50/40 , A23L33/10 , A23L33/19 , A61K8/19 , A61K8/64 , A61K9/0014 , A61K31/19 , A61K33/06 , A61K33/10 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K38/16 , A61K38/40 , A61K45/06 , A61Q19/02 , A61K2300/00
摘要： Disclosed are: a skin whitening agent comprising, as an active ingredient, a complex of carbonic acid and/or bicarbonic acid, a metal and an LF, a decomposition product of the complex, or a complex of carbonic acid and/or bicarbonic acid, a metal and a decomposition product of an LF; and a food, beverage, feed or cosmetic comprising the skin whitening agent. The skin whitening agent can be ingested safely on a daily basis, and exhibits an excellent skin whitening effect.
摘要翻译： 公开了一种皮肤增白剂，其包含作为活性成分的碳酸和/或碳酸氢盐，金属和LF的络合物，络合物的分解产物或碳酸和/或碳酸氢盐的络合物， LF的金属和分解产物; 和包含皮肤增白剂的食品，饮料，饲料或化妆品。 皮肤美白剂可以每天安全摄取，并具有优异的皮肤美白效果。
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公开(公告)号：EP2221057A1
公开(公告)日：2010-08-25
申请号：EP08851416.1
申请日：2008-11-19
IPC分类号： A61K31/688 , A23L1/30 , A61K8/55 , A61P25/02 , A61Q19/00
CPC分类号： A61Q19/00 , A23K20/158 , A23K20/26 , A23K50/40 , A23L2/52 , A23L33/115 , A61K8/0212 , A61K8/553 , A61K8/68 , A61K31/688
摘要： Disclosed are: sense-improving agent which comprises, as an active ingredient, a phospholipid or a sphingosine-containing phospholipid and/or a derivative thereof, particularly a sphingomyelin, and which has an effect of improving the dulling of senses at a periphery when ingested orally or directly applied to the skin; and a sense-improving food, beverage, feed or cosmetic comprising the sense-improving agent. The phospholipid to be used may be a chemically synthesized phospholipid or a naturally occurring phospholipid, preferably a phospholipid derived from an edible material such as soybean and egg yolk, particularly preferably a phospholipid derived from milk.
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公开(公告)号：EP2143725A1
公开(公告)日：2010-01-13
申请号：EP08722373.1
申请日：2008-03-18
发明人： ISOGAI, Tomoyuki , MIURA, Susumu , KATO, Ken , TANAKA, Reo , MURAKAMI, Mototake , YOSHIOKA, Toshimitsu
IPC分类号： C07H15/04
摘要： Manufacture a lactosylceramide useful as a reagent in the fields of medicine, pharmacology, biochemistry, etc., and also useful as a material for producing pharmaceutical preparations, cosmetics, drinks and food, feeds, and so on, by heating ganglioside GD 3 and/or ganglioside GM 3 in a pH range of 3 to 5 and temperature range of 70°C to 100°C for a period of 30 to 180 minutes, after which the pH is further adjusted to a range of 4.5 to 5.0, followed by concentration using a method using ultrafiltration membranes, etc.
摘要翻译： 制造用作药物，药理学，生物化学等领域的试剂的乳糖神经酰胺，也可用作制备药物制剂，化妆品，饮料和食品，饲料等的材料，通过加热神经节苷脂GD 3和/ 或神经节苷脂GM 3，pH范围为3〜5，温度范围为70℃〜100℃，时间为30〜180分钟，然后将pH值进一步调节至4.5〜5.0的范围，然后浓度 使用超滤膜等方法
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公开(公告)号：EP2138159A1
公开(公告)日：2009-12-30
申请号：EP08721729.5
申请日：2008-03-10
发明人： WATANABE, Tatsuya , KATO, Ken , UENO, Hiroshi , HARUTA, Yuko , UEDA, Noriko , YOSHIOKA, Toshimitsu
CPC分类号： A61K35/20 , A23C9/1526 , A23K20/147 , A23K50/40 , A23L2/52 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/00 , A61K38/018 , A61K2800/92 , A61Q19/02
摘要： A skin-whitening agent offering an excellent whitening effect and being effective in preventing and treating age spots, freckles, etc., where such skin-whitening agent contains as its effective ingredient a whey protein hydrolyzate characterized by a molecular weight distribution of 10 kDa or less, main peak of 200 Da to 3 kDa, APL (average peptide-chain length) of 2 to 8, free amino acid content of 20% or less, and antigenicity of one-ten thousandth of β-lactoglobulin or less, as well as a cosmetic, drink or food, feed, pharmaceutical preparation or other skin-whitening product containing such skin-whitening agent.
摘要翻译： 本发明提供美白效果优异，能够有效预防和治疗老年斑，雀斑等的美白剂，其中，该美白剂含有以分子量分布10kDa为特征的乳清蛋白水解物作为有效成分，或 200Da〜3kDa的主峰，2〜8的APL（平均肽链长度），20％以下的游离氨基酸含量，以及β-乳球蛋白的千分之一以下的抗原性 作为含有这种美白剂的化妆品，饮料或食品，饲料，药物制剂或其他美白产品。
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公开(公告)号：EP2011500A1
公开(公告)日：2009-01-07
申请号：EP07741227.8
申请日：2007-04-06
发明人： TANAKA, Reo , ISOGAI, Tomoyuki , HARUTA, Yuko , MIURA, Susumu , KATO, Ken , YOSHIOKA, Toshimitsu , KAWAKAMI, Hiroshi , HIGURASHI, Satoshi , MATSUYAMA, Hiroaki
IPC分类号： A61K31/661 , A23L1/30 , A23L2/00 , A61K35/20 , A61P3/04
CPC分类号： A61K35/20 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K31/661 , A23V2200/332 , A23V2250/1844
摘要： To provede a fat accumulation inhibitor and a food or drink for inhibiting fat accumulation, a visceral fat accumulation inhibitor and a food or drink for inhibiting visceral fat accumulation, or an agent for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood and a food or drink for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood.
A fat accumulation inhibitor for a fat cell, which comrises a milk-derived phospholipid as an active ingredient, and a food or drink for inhibiting fat accumulation in a fat cell, which comprises a milk-derived phospholipid. A visceral fat accumulation inhibitor comprising a sphingosine-containing phospholipid or a derivative thereof as an active ingredient, and a food or drink for inhibiting visceral fat accumulation. An agent for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood , which comprises a sphingosine-containing phospholipid or a derivative thereof as an active ingredient, and a food or drink for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood.摘要翻译： 证明脂肪蓄积抑制剂和用于抑制脂肪蓄积的食物或饮料，内脏脂肪蓄积抑制剂和用于抑制内脏脂肪蓄积的食品或饮料，或用于加速和/或抑制血液中脂联素浓度降低的试剂，以及 用于加速和/或抑制血液中脂联素浓度降低的食物或饮料。 一种脂肪蓄积抑制剂，其含有来自乳的磷脂作为活性成分的脂肪细胞，以及用于抑制脂肪细胞中的脂肪蓄积的食品或饮料，其包含乳源性磷脂。 一种含有含鞘氨醇的磷脂或其衍生物作为活性成分的内脏脂肪蓄积抑制剂和抑制内脏脂肪蓄积的食品或饮料。 用于促进增加和/或抑制血液中脂联素浓度降低的试剂，其包含含鞘氨醇的磷脂或其衍生物作为活性成分，以及用于加速和/或抑制脂联素浓度降低的食品或饮料 在血液中
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公开(公告)号：EP1938695A1
公开(公告)日：2008-07-02
申请号：EP06810632.7
申请日：2006-09-27
发明人： MIURA, Susumu , KOJIMA, Kenji , NAKANO, Taku , KATO, Ken , TOMIZAWA, Akira , YOSHIOKA, Toshimitsu
CPC分类号： A23J7/00 , A23C9/142 , A23C17/00 , A23C2240/05 , A23L33/115 , A23L33/19 , A23V2002/00 , A23V2250/5424
摘要： Manufacture a powder with high milk-derived complex lipid content that contains milk-derived phospholipids and milk-derived ganglioside at high concentrations, which contains protein by 15 to 35 percent by dry weight and fat by 45 to 60 percent by dry weight, wherein the content of milk-derived complex lipids is 20 percent by dry weight or more, and which can be utilized as a material for functional food, mother's milk substitute or drug, by means of adjusting the pH value of a butter serum or butter serum powder reconstituted liquid to a range of 4.0 to 5.0, adding calcium chloride to promote coagulation of protein, removing the produced sediments, filtering the supernatant by means of ultrafiltration or microfiltration, and then drying the obtained concentrate.
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9.发明公开MICROORGANISM-PROTECTING AGENT, AND METHOD FOR PRODUCTION OF FROZEN OR LYOPHILIZED MICROBIAL CELL 有权MICRO-保护装置及其制造方法冷冻或冻干微生物细胞
公开(公告)号：EP2241615A1
公开(公告)日：2010-10-20
申请号：EP09708024.6
申请日：2009-02-03
IPC分类号： C12N1/20
CPC分类号： C12N1/04
摘要： The present invention provides a method of preparing frozen or lyophilized microbial cells which can inhibit damages or death of microbial cells and have high viabilities in freezing or lyophilizing process.
A method of preparing frozen or lyophilized microbial cells having high viabilities, characterized by using a permeate which is obtained by filtering milk or whey with ultra-filtration (UF) membrane, as a protecting agent at the time of freezing or lyophilizing.摘要翻译： 本发明提供一种制备冷冻或冻干的微生物细胞可以抑制损害或微生物细胞的死亡，并且具有在冷冻或冻干过程的高存活率的方法。 制备具有高存活率，通过使用渗透所有这一切是通过过滤乳或乳清用超过滤（UF）膜，如在冷冻或冻干时的保护剂为特征的获得冷冻或冻干的微生物细胞的方法。
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公开(公告)号：EP2127540A1
公开(公告)日：2009-12-02
申请号：EP08704064.8
申请日：2008-01-29
发明人： KATO, Ken , HARUTA, Yuko , WATANABE, Tatsuya , UENO, Hiroshi , UEDA, Noriko , YOSHIOKA, Toshimitsu
CPC分类号： A61K31/661 , A23K20/158 , A23K50/40 , A23L33/10 , A23L33/12 , A23V2002/00 , A23V2200/318 , A23V2250/18
摘要： The present invention aims to provide a skin-beautifying agent, food, beverage, or feed for skin-beautification which has cosmetic effects such as moisturizing and beautifying the skin as well as preventing skin roughness and wrinkles by oral intake. The present invention further aims to provide a skin-beautifying agent containing a milk-derived phospholipid as an effective ingredient, and to provide food, beverage, or feed for skin-beautification containing the skin-beautifying agent. The milk-derived phospholipid is preferably a composition prepared from milk or milk material containing 40 to 70% by weight of lipid in a total solid content and containing 30% or more by weight of milk-derived phospholipid.
摘要翻译： 本发明的目的在于提供一种具有保湿，美化皮肤等美容效果并且通过口服摄取来防止皮肤粗糙和皱纹的皮肤美化剂，食品，饮料或美容用饲料。 本发明的目的还在于提供一种含有乳来源的磷脂作为有效成分的美肤剂，并且提供含有该美肤剂的用于美肤的食品，饮料或饲料。 乳来源的磷脂优选为由乳或乳原料制备的组合物，其含有总固体含量为40至70重量％的脂质，并且含有30重量％或更多的源自乳源的磷脂。
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