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    Compounds useful for treating AIDS
    1.
    发明公开
    Compounds useful for treating AIDS 审中-公开
    NützlicheVerbindungen zur Behandlung von AIDS

    公开(公告)号：EP2465502A1

    公开(公告)日：2012-06-20

    申请号：EP10306417.6

    申请日：2010-12-15

    申请人： Société Splicos ,  Centre National de la Recherche Scientifique CNRS ,  Institut Curie ,  Université Montpellier II

    发明人： Tazi, Jamal ,  Mahuteau, Florence ,  Najman, Romain

    IPC分类号： A61K31/47 ,  A61P31/18

    CPC分类号： C07D215/38 ,  C07D295/135 ,  C07D401/12

    摘要： The present invention relates to compound (I)

    for use as an agent for preventing, inhibiting or treating AIDS.
    The present invention further relates to compounds of formula (I) wherein X is CR 0 or N; R 0 , R 1 , R 2 , R 3 , R 4 , R 7 and R 8 independently represent a hydrogen atom, a halogen atom or a group chosen among a (C 1 -C 5 )alkyl group, a (C 3 -C 6 )cycloalkyl group, a (C 1 -C 5 )fluoroalkyl group, a (C 1 -C 5 )alkoxy group, a (C 1 -C 5 )fluoroalkoxy group, a -CN group, a -COOR a group, a -NO 2 group, a -NR a R b group, a -NR a- SO 2- NR a R b group, a -NR a- SO 2- R a group, a -NR a -C(=O)-R a group, a -NR a -C(=O)-NR a R b group, a -SO 2- NR a R b group, a -SO 3 H group, a -OH group, a -O-SO 2 -OR c group, a -O-P(=O)-(OR c )(OR d ) group, a -O-CH 2 -COOR c group and can further be a group chosen among:

    R 5 represents a hydrogen atom, a (C 1 -C 5 )alkyl group or a (C 3 -C 6 )cycloalkyl group; R 10 is a hydrogen atom or a chlorine atom, and R 11 is a hydrogen atom or a (C 1 -C 4 )alkyl group or anyone of its pharmaceutically acceptable salts.

    摘要翻译： 本发明涉及用作预防，抑制或治疗AIDS的药剂的化合物（I）。 本发明还涉及其中X为CR 0或N的式（I）化合物; R 0，R 1，R 2，R 3，R 4，R 7和R 8独立地表示氢原子，卤素原子或选自（C 1 -C 5）烷基，（C 3〜 C 6）环烷基，（C 1 -C 5）氟代烷基，（C 1 -C 5）烷氧基，（C 1 -C 5）氟烷氧基，-CN基，-COOR a基， -NO 2基团，-NR a R b基团，-NR a -SO 2 NR a R b基团，-NR a -SO 2 R a基团，-NR a -C（= O） -R a基团，-NR a -C（= O）-NR a R b基团，-SO 2 NR a R b基团，-SO 3 H基团，-OH基团，-O-SO 2 -OR c基团，-OP（= O） - （OR c）（OR d）基团，-O-CH 2 -COOR c基团，可以进一步选自：R 5表示氢原子， （C 1 -C 5）烷基或（C 3 -C 6）环烷基; R 10为氢原子或氯原子，R 11为氢原子或（C 1〜C 4）烷基或其任何药学上可接受的盐。

    New anti-invasive compounds
    2.
    发明公开
    New anti-invasive compounds 审中-公开
    新型抗侵袭型

    公开(公告)号：EP2712862A1

    公开(公告)日：2014-04-02

    申请号：EP12186684.2

    申请日：2012-09-28

    申请人： Splicos ,  Centre National de la Recherche Scientifique ,  Institut Curie ,  Université Montpellier II

    发明人： Roux, Pierre ,  Mahuteau, Florence ,  Najman, Romain ,  Gadea, Gilles ,  Tazi, Jamal ,  Scherrer, Didier ,  Brock, Carsten ,  Cahuzac, Nathalie, M.

    IPC分类号： C07D213/75 ,  C07D239/42 ,  C07D401/12 ,  A61K31/44 ,  A61P35/00

    CPC分类号： C07D401/14 ,  C07D213/75 ,  C07D239/42 ,  C07D401/12

    摘要： The present invention relates to a compound of formula (I):

    wherein
    A and A' independently represent a phenylene group or a pyridylene group; R 2 is a hydrogen atom or a (C 1 -C 4 )alkyl group; R 3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R 4 is a carbonyl group or a sulfonyl group; and R 5 is a - NH-(CH 2 ) a -NR 6 R 7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R 6 and R 7 representing independently a (C 1 -C 4 )alkyl group, or R 6 and R 7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.
    The invention further relates to pharmaceutical compositions containing a compound of formula (I) or any one of its pharmaceutically acceptable salt and a preparation process for obtaining the same. Said compounds (I) are useful for treating cancer.

    摘要翻译： 本发明涉及式（I）化合物：其中A和A'独立地表示亚苯基或亚吡啶基; R 2是氢原子或（C 1 -C 4）烷基; R 3为2-吡啶基，3-吡啶基，4-吡啶基，2-嘧啶基，4-嘧啶基或5-嘧啶基; R 4是羰基或磺酰基; 和R 5是-NH - （CH 2）a -NR 6 R 7基或4-甲基哌嗪基，其中1至4的整数，R 6和R 7独立地表示（C 1 -C 4） ）烷基，或R 6和R 7与它们所连接的氮原子一起形成选自4-甲基哌嗪基，吗啉代基，吡咯烷基和哌啶子基的杂环基; 或其药学上可接受的盐中的任何一种。 本发明还涉及含有式（I）化合物或其药学上可接受的盐中的任何一种的药物组合物及其制备方法。 所述化合物（I）可用于治疗癌症。

    Methods for screening compounds for treating or preventing a viral infection or a virus-related condition
    5.
    发明公开
    Methods for screening compounds for treating or preventing a viral infection or a virus-related condition 审中-公开
    方法筛选的化合物用于病毒感染的治疗或预防或病毒相关疾病

    公开(公告)号：EP3059591A1

    公开(公告)日：2016-08-24

    申请号：EP15305276.6

    申请日：2015-02-23

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Institut Curie ,  Université Montpellier

    发明人： Scherrer, Didier ,  Garcel, Aude ,  Campos, Noelie ,  Vautrin, Audrey ,  Mahuteau-Betzer, Florence ,  Najman, Romain ,  Fornarelli, Pauline ,  Tazi, Jamal

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56983 ,  G01N2333/16 ,  G01N2469/10 ,  G01N2500/02 ,  G01N2500/10

    摘要： The present invention relates to a method for screening a compound useful for treating or preventing a viral infection or a virus-related condition in an individual, comprising at least the steps of:
    a) determining the ability of a candidate compound to promote the interaction between CBP20 and CBP80 in a sample, and
    b) selecting the candidate compound that is determined to promote said interaction at step a).
    The present invention further relates to a method for screening a compound useful for treating or preventing a viral infection or virus-related condition in an individual, comprising at least the steps of:
    a) determining the ability of a candidate compound to interact with CBP20 or CBP80 in a sample, and
    b) selecting the candidate compound that is determined to interact with CBP20 or CBP80 at step a).

    摘要翻译： 本发明涉及一种用于筛选用于治疗或预防病毒感染或在个体的病毒相关病症有用的化合物的方法，包括至少以下步骤：a）确定的采矿的候选化合物，以促进之间的相互作用的能力 CBP20和CBP80的样品中，和b）选择所述候选化合物确实是确定性的开采，以促进在步骤a）中所述相互作用。 本发明还涉及一种方法，用于筛选用于治疗或预防病毒感染或在单独的病毒相关病症有用的化合物，其至少包括以下步骤：a）确定的采矿的候选化合物的能力与CBP20或交互 CBP80的样品中，和b）选择所述候选化合物确实是确定性的开采在步骤a）中与CBP20或CBP80进行交互。

    Quinoline derivatives for use in the treatment or prevention of viral infection
    7.
    发明公开
    Quinoline derivatives for use in the treatment or prevention of viral infection 审中-公开
    Chinolin-Derivate zur Behandlung oder Vorbeugung von viralen Infektionen

    公开(公告)号：EP3058940A1

    公开(公告)日：2016-08-24

    申请号：EP15305277.4

    申请日：2015-02-23

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Institut Curie ,  Université Montpellier

    发明人： Scherrer, Didier ,  Garcel, Aude ,  Campos, Noelie ,  Tazi, Jamal ,  Vautrin, Audrey ,  Mahuteau-Betzer, Florence ,  Najman, Romain ,  Fornarelli, Pauline

    IPC分类号： A61K31/4709 ,  A61P31/18

    CPC分类号： A61K31/47 ,  A61K31/4709 ,  A61K31/706 ,  A61K2300/00

    摘要： The present invention relates to A quinoline derivative of formula (I)

    or anyone of its pharmaceutically acceptable salt, or anyone of its metabolites,
    for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient; and then terminating said treatment when: the viral load is low or undetectable; and/or the level of CD4+ cell count is maintained or restored.
    The present invention further relates to a quinoline derivative of formula (I) as defined in claim 1, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, for which an ineffectiveness or a decline in a prior anti-retroviral treatment effectiveness has been stated and to a quinoline derivative of formula (I) as defined above, or anyone of its pharmaceutically acceptable salts and metabolites, for use for treating or preventing a viral infection, in particular a HIV infection or a HIV-related condition in a patient, wherein the patient is infected by a drug-resistant viral strain, and more particularly by a drug-resistant HIV strain.

    摘要翻译： 本发明涉及式（I）的喹啉衍生物或其任何其药学上可接受的盐或其任何代谢物，用于治疗或预防病毒感染，特别是HIV感染或HIV相关病症 患者; 然后在以下情况下终止所述治疗：病毒载量低或不可检测; 和/或维持或恢复CD4 +细胞计数的水平。 本发明还涉及如权利要求1所定义的式（I）喹啉衍生物或其任何药学上可接受的盐和代谢物，用于治疗或预防病毒感染，特别是HIV感染或HIV相关 已经陈述了先前的抗逆转录病毒治疗有效性的无效性或下降的患者以及上述式（I）的喹啉衍生物或其药学上可接受的盐和代谢物中的任何一种，用于 治疗或预防患者的病毒感染，特别是HIV感染或HIV相关病症，其中患者被抗药性病毒株感染，特别是耐药性HIV毒株。

    Compounds useful to treat premature aging and in particular progeria
    8.
    发明公开
    Compounds useful to treat premature aging and in particular progeria 审中-公开
    组合物过早老化的治疗和在使用中的特定哈钦森-吉尔福德综合征

    公开(公告)号：EP2261214A1

    公开(公告)日：2010-12-15

    申请号：EP09162630.9

    申请日：2009-06-12

    申请人： Splicos Sas ,  CNRS (Centre National de La Recherche Scientifique) ,  Institut Curie ,  Université Montpellier 2

    发明人： Mahuteau, Florence ,  Tazi, Jamal ,  Najman, Romain

    IPC分类号： C07D215/38 ,  C07D401/12 ,  A61K31/33 ,  A61P43/00

    CPC分类号： C07D401/12 ,  C07D215/38

    摘要： The present invention relates to a compound of formula (I):

    wherein:

    means an aromatic ring wherein V is C or N and when V is N, V is in ortho, meta or para of Z, i.e. forms respectively a pyridazine, a pyrimidine or a pyrazine group,
    R independently represents a hydrogen atom, a halogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a -CN group, a -COOH group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a -NO 2 group, a -NR 1 R 2 group and a (C 1 -C 3 )alkoxy group,
    R 1 and R 2 are independently a hydrogen atom or a (C 1 -C 3 )alkyl group,
    n is 1 or 2,
    R' is a hydrogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a halogen atom, a hydroxy group, a -COOH group and a -CN group,
    R" is a hydrogen atom or a (C 1 -C 4 )alkyl group,
    Z is N or C,
    Y is N or C,
    X is N or C,
    W is N or C,

    and wherein at most two of the groups Z, Y, X and W are N,
    or anyone of its pharmaceutically acceptable salt,
    for use as an agent for preventing, inhibiting or treating pathological or nonpathological conditions linked with premature aging.

    摘要翻译： 本发明涉及式（I）的化合物：worin：芳环worinⅤ的手段是C或N，并且当V是N，V是在邻位，间位或Z的对位，即 分别形成哒嗪，嘧啶或吡嗪基，R独立地darstellt氢原子，卤原子或（C 1 -C 3）烷基，-CN基，-COOH基，一个中选择的基团（ C 1 -C 3）氟烷基，（C 1 -C 3）氟烷基，-NO 2基，-NR 1 R 2基团和（C 1 -C 3）烷氧基，R 1和R 2 独立地为氢原子或（C 1 -C 3）烷基基团，n是1或2，R“为氢原子或（C 1 -C 3）中选择的烷基基团，一个卤素原子，一个基团 羟基基团，-COOH基团和-CN基团，R“是氢原子或（C 1 -C 4）烷基基团，Z为N或C，Y是N或C，X为N或C，W 是N或C，以及worin至多两个基团Z，Y，X和W的为N，或其药学上可接受的盐中的任何一个，其用作用于预防，抑制性或治疗与过早老化联的病理或nonpathological条件的试剂 ，