公开(公告)号：EP3148599A1

公开(公告)日：2017-04-05

申请号：EP15725376.6

申请日：2015-06-01

申请人： Sofradim Production

发明人： JAILLON, Amandine ,  SERRERO, Aurélie

IPC分类号： A61L27/24 ,  A61L27/36 ,  A61L27/50 ,  A61L15/32

摘要： The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of: —a) preparing an acidic solution of non-antigenic collagenous material, —b) pouring the solution of a) into a mold in order to form a layer, —c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.

摘要翻译： 本发明涉及一种制备非抗原性胶原材料中和基质的方法，包括以下步骤：a）制备非抗原性胶原材料的酸性溶液，b）将a）的溶液倒入模具中 为了形成层，c）冻结b）层以获得非抗原性胶原材料的酸性基质，d）用环氧乙烷对c）中得到的酸性基质进行灭菌，以获得中和的基质 非抗原性胶原材料。 本发明还涉及获得的基质和包含这种基质的外科植入物。

公开(公告)号：EP3148598A1

公开(公告)日：2017-04-05

申请号：EP15727617.1

申请日：2015-05-29

申请人： Sofradim Production

发明人： SERRERO, Aurélie ,  MONTANARI, Suzelei ,  VESTBERG, Robert

IPC分类号： A61L24/04 ,  A61L27/20 ,  A61L27/34 ,  A61L27/58 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L24/00

CPC分类号： A61L27/20 ,  A61L24/0042 ,  A61L24/043 ,  A61L27/34 ,  A61L27/56 ,  A61L27/58 ,  A61L31/042 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2400/04 ,  A61L2420/08 ,  C08L1/04 ,  C08L5/08

摘要： The present invention relates to an implant (10) comprising: -a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.0 to 1, and -a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.

摘要翻译： 本发明涉及在植入物（10），包括： - 基片（1），其中包含氧化纤维素的表面上，所述具有氧化度范围从0到1的氧化纤维素，以及 - 一个多层涂层覆盖所述基材， 所述多层涂层，其包括至少第一层（2）相邻的所述衬底，所述形成壳聚糖的第一层和第二层（3）邻近所述第一层，所述形成具有范围氧化度的氧化纤维素的第二层 为0.5至1。本发明还涉及一种用于制备寻求植入物。

公开(公告)号：EP3148599B1

公开(公告)日：2019-12-18

申请号：EP15725376.6

申请日：2015-06-01

申请人： Sofradim Production

发明人： JAILLON, Amandine ,  SERRERO, Aurélie

IPC分类号： A61L27/24 ,  A61L27/36 ,  A61L27/50 ,  A61L15/32

公开(公告)号：EP2563416A2

公开(公告)日：2013-03-06

申请号：EP11749904.6

申请日：2011-04-28

申请人： Sofradim Production

发明人： MONTANARI, Suzelei ,  SERRERO, Aurélie

IPC分类号： A61L15/28 ,  A61L15/42

CPC分类号： A61B17/08 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/02

摘要： Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.

公开(公告)号：EP2900280B1

公开(公告)日：2018-08-01

申请号：EP13766967.7

申请日：2013-09-25

申请人： Sofradim Production

发明人： SERRERO, Aurélie ,  MONTANARI, Suzelei

IPC分类号： A61L15/28 ,  A61L15/44 ,  A61L15/64 ,  C08L1/02 ,  C08L5/08

CPC分类号： A61L15/28 ,  A61L15/44 ,  A61L15/64 ,  A61L2400/04 ,  B32B37/0038 ,  B32B37/1284 ,  B32B37/24 ,  B32B38/162 ,  B32B2305/026 ,  B32B2317/18 ,  B32B2535/00 ,  B32B2555/00 ,  C08L1/04 ,  C08L5/08 ,  Y10T156/10

摘要： The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps: —a°) preparing a porous layer based on oxidized cellulose, —b°) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan, —c°) fixing the film obtained in b°) on one face of the porous layer, —d°) neutralizing the film obtained in b°), —where step c°) can be carried out before or after step d°), characterized in that: the neutralizing step d°) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).

公开(公告)号：EP2563416B1

公开(公告)日：2016-11-09

申请号：EP11749904.6

申请日：2011-04-28

申请人： Sofradim Production

发明人： MONTANARI, Suzelei ,  SERRERO, Aurélie

IPC分类号： A61L15/28 ,  A61L15/42

CPC分类号： A61B17/08 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/02

公开(公告)号：EP2900280A1

公开(公告)日：2015-08-05

申请号：EP13766967.7

申请日：2013-09-25

申请人： Sofradim Production

发明人： SERRERO, Aurélie ,  MONTANARI, Suzelei

IPC分类号： A61L15/28 ,  A61L15/44 ,  A61L15/64 ,  C08L1/02 ,  C08L5/08

CPC分类号： A61L15/28 ,  A61L15/44 ,  A61L15/64 ,  A61L2400/04 ,  B32B37/0038 ,  B32B37/1284 ,  B32B37/24 ,  B32B38/162 ,  B32B2305/026 ,  B32B2317/18 ,  B32B2535/00 ,  B32B2555/00 ,  C08L1/04 ,  C08L5/08 ,  Y10T156/10

摘要： The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps: —a°) preparing a porous layer based on oxidized cellulose, —b°) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan, —c°) fixing the film obtained in b°) on one face of the porous layer, —d°) neutralizing the film obtained in b°), —where step c°) can be carried out before or after step d°), characterized in that: the neutralizing step d°) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).

摘要翻译： 本发明涉及一种止血贴片，其包括基于氧化纤维素的多孔层和基于壳聚糖的中和膜，所述膜包含固定在多孔层的一个表面上的自由面和面，以及制备方法 所述贴片包括以下步骤：-a°）基于氧化纤维素制备多孔层，-b°）从壳聚糖的酸性水溶液制备基于壳聚糖的膜，-c°）将以b°获得的膜定影 ）在步骤d°）之前或之后进行，其中步骤c°）可以在步骤d°）之后进行，其特征在于：中和步骤d°） 包括用至少包含乙醇和氢氧化铵（NH 4 OH）的中和组合物处理所述膜。