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1.发明公开
公开(公告)号：EP0420683A3
公开(公告)日：1992-01-15
申请号：EP90310663.1
申请日：1990-09-28
发明人： Okahata, Yoshio , Yomemori, Kazuyuki, c/o Sogo Pharma. Co. Ltd. , Fujita, Shinsuke, c/o Sogo Pharma. Co. Ltd.
CPC分类号： G01N29/036 , G01N33/15 , G01N2291/0256
摘要： A method of evaluating the physioiogical activities and structural characteristics of medicinal substances, which method comprises determining correlations of (A) at least one of kinds of lipid films, physiological activity factors of medicinal substances and structural characteristics of medicinal substances with (B) at least one of amounts of change in frequency, adsorbed amounts or interacted amounts due to adsorption or interaction of the medicinal substances onto the lipid films and lipid film-water partition coefficients, by use of crystal oscillators cast various lipid films respectively, wherein the lipid film-water partition coefficient is used as a parameter in the structural activity correlation technique for medicinal substances.
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2.发明公开
公开(公告)号：EP0420683A2
公开(公告)日：1991-04-03
申请号：EP90310663.1
申请日：1990-09-28
发明人： Okahata, Yoshio , Yomemori, Kazuyuki, c/o Sogo Pharma. Co. Ltd. , Fujita, Shinsuke, c/o Sogo Pharma. Co. Ltd.
CPC分类号： G01N29/036 , G01N33/15 , G01N2291/0256
摘要： A method of evaluating the physioiogical activities and structural characteristics of medicinal substances, which method comprises determining correlations of (A) at least one of kinds of lipid films, physiological activity factors of medicinal substances and structural characteristics of medicinal substances with (B) at least one of amounts of change in frequency, adsorbed amounts or interacted amounts due to adsorption or interaction of the medicinal substances onto the lipid films and lipid film-water partition coefficients, by use of crystal oscillators cast various lipid films respectively, wherein the lipid film-water partition coefficient is used as a parameter in the structural activity correlation technique for medicinal substances.
摘要翻译： 评价的physioiogical活动和药用物质，该方法包括（A）确定的采矿相关种脂质膜的，药用物质，并用（B）至少的医药物质结构特征生理活性因子中的至少一个结构特征的方法 在频率变化量中的一个，吸附量或由于吸附或药用物质的相互作用走上脂质膜和脂质 - 电影 - 水分配系数的相互作用量，通过使用分别投各种脂质膜晶体振荡器，worin脂质成膜 水分配系数被用作药用物质的结构活性相关技术的参数。
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公开(公告)号：EP0282332A3
公开(公告)日：1989-10-18
申请号：EP88302154.5
申请日：1988-03-11
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N27/327 , G01N2291/0256 , Y10T436/255
摘要： Disclosed are a method of detecting bitter or odor substances, which method comprises adsorbing the bitter or odor substances onto an immobilized bilayer film and directly, quantitatively, separately, and selectively detecting the adsorbed bitter or odor substances, and an apparatus therefor.
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4.发明公开A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a crystal oscillator used therefor 失效确定在离子溶液中含有的物质或离子的量的方法或非离子溶液和使用的晶体振荡器的方法
公开(公告)号：EP0359473A3
公开(公告)日：1990-11-22
申请号：EP89309071.2
申请日：1989-09-07
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N33/84 , G01N2291/0256
摘要： Disclosed are a method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution by measuring the frequency of a one side barrier-covered crystal oscillator comprising a crystal oscillator 1,2a,2b, a barrier 6 to cover over one of the electrodes 2b of the crystal oscillator through a predetermined insulative space 5 so as to prevent the ionic solution or the non-deionized solution from permeating therethrough and an adsorption film 7 cast on the other electrode 2a of the crystal oscillator, in situ in the state that the one side barrier-covered crystal oscillator is dipped in the ionic solution or the non-deionized solution, and the one side barrier-covered crystal oscillator used therefor.
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公开(公告)号：EP0282332A2
公开(公告)日：1988-09-14
申请号：EP88302154.5
申请日：1988-03-11
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N27/327 , G01N2291/0256 , Y10T436/255
摘要： Disclosed are a method of detecting bitter or odor substances, which method comprises adsorbing the bitter or odor substances onto an immobilized bilayer film and directly, quantitatively, separately, and selectively detecting the adsorbed bitter or odor substances, and an apparatus therefor.
摘要翻译： 本发明公开了检测苦味或臭气物质的方法，该方法包括方法吸附苦味或异味物质走上到固定化双层膜和直接，定量地，单独地和选择性地检测所述吸附苦味或异味物质，并为此设备。
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公开(公告)号：EP0282332B1
公开(公告)日：1994-07-06
申请号：EP88302154.5
申请日：1988-03-11
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N27/327 , G01N2291/0256 , Y10T436/255
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7.发明公开Method of detecting biochemical substances and sensor for use in said method 失效检测生物化学物质的方法和传感器用于实验方法
公开(公告)号：EP0589600A3
公开(公告)日：1996-12-18
申请号：EP93307198.7
申请日：1993-09-13
CPC分类号： C12Q1/6825 , G01N29/036 , G01N2291/0255
摘要： A method of detecting biochemical substances which method comprises chemically binding and immobilizing a probe DNA having a sequence complementary with a sequence specific to a DNA of a biochemical substance onto an electrode of a frequency conversion element, hybridizing the probe DNA with a sample to detect said DNA as a target DNA having a sequence specific to the probe DNA, and measuring frequency changes corresponding to mass changes due to hybridization to detect and identify a hybridized DNA; and a sensor use in the above method.
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8.发明公开Method of detecting biochemical substances and sensor for use in said method 失效一种用于检测的生物化学物质和适当的传感器的方法。
公开(公告)号：EP0589600A2
公开(公告)日：1994-03-30
申请号：EP93307198.7
申请日：1993-09-13
CPC分类号： C12Q1/6825 , G01N29/036 , G01N2291/0255
摘要： A method of detecting biochemical substances which method comprises chemically binding and immobilizing a probe DNA having a sequence complementary with a sequence specific to a DNA of a biochemical substance onto an electrode of a frequency conversion element, hybridizing the probe DNA with a sample to detect said DNA as a target DNA having a sequence specific to the probe DNA, and measuring frequency changes corresponding to mass changes due to hybridization to detect and identify a hybridized DNA; and a sensor use in the above method.
摘要翻译： 用样品以检测所述检测生化物质，该方法包括在化学上结合和固定具有的频率转换元件的电极的特定的生物化学物质的DNA序列走上探针互补的序列的DNA，杂交的探针DNA的方法 DNA为具有特定的DNA样本的序列，以及测量频率的变化对应于由于杂交的质量变化，以检测并识别一个杂交的DNA的目标DNA; 并且在上述方法中的传感器使用。
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9.发明授权A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a crystal oscillator used therefor 失效步骤，用于确定在离子溶液中或在溶液nichtentionisierten和晶体振荡器用于此目的的物质的量。
公开(公告)号：EP0359473B1
公开(公告)日：1993-12-15
申请号：EP89309071.2
申请日：1989-09-07
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N33/84 , G01N2291/0256
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10.发明公开A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a crystal oscillator used therefor 失效步骤，用于确定在离子溶液中或在溶液nichtentionisierten和晶体振荡器用于此目的的物质的量。
公开(公告)号：EP0359473A2
公开(公告)日：1990-03-21
申请号：EP89309071.2
申请日：1989-09-07
发明人： Okahata, Yoshio
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N33/84 , G01N2291/0256
摘要： Disclosed are a method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution by measuring the frequency of a one side barrier-covered crystal oscillator comprising a crystal oscillator 1,2a,2b, a barrier 6 to cover over one of the electrodes 2b of the crystal oscillator through a predetermined insulative space 5 so as to prevent the ionic solution or the non-deionized solution from permeating therethrough and an adsorption film 7 cast on the other electrode 2a of the crystal oscillator, in situ in the state that the one side barrier-covered crystal oscillator is dipped in the ionic solution or the non-deionized solution, and the one side barrier-covered crystal oscillator used therefor.
摘要翻译： 公开的是物质或离子的量在离子溶液或通过测量一个侧屏障覆盖的晶体振荡器的频率，包括一个晶体振荡器1,2A，2B的非去离子溶液，屏障6包含在确定性采矿的方法 通过预定的绝缘空间5在晶体振荡器的电极2b的一个覆盖，以便防止从通过渗透有离子溶液或所述非去离子溶液和在晶体振荡器的另一个电极2A吸附膜-7铸， 原位的状态下做的一个侧屏障覆盖的晶体振荡器浸渍在离子溶液或所述非去离子溶液，为此所用的一个侧屏障覆盖的晶体振荡器。
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