-
1.发明公开METHOD AND APPARATUS FOR THE AUTOMATED GENERATION OF NUCLEIC ACID LIGANDS 审中-公开METHOD AND APPARATUS FOR自动生成的核酸配体
公开(公告)号：EP1144669A1
公开(公告)日：2001-10-17
申请号：EP00909909.4
申请日：2000-01-14
申请人： Somalogic, Inc.
CPC分类号： C12Q1/6811 , B01J2219/00315 , B01J2219/00364 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00702 , B01J2219/00722 , C12N15/1048 , C40B40/06 , C40B60/14
摘要： The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a cartesian robotic manipulator controlled by a computer.
-
2.发明公开METHODS AND REAGENTS FOR DETECTING TARGET BINDING BY NUCLEIC ACID LIGANDS 审中-公开方法和试剂进行目标分子的检测同位素标记配体的结合
公开(公告)号：EP1481090A1
公开(公告)日：2004-12-01
申请号：EP03713423.6
申请日：2003-02-10
申请人： SomaLogic, Inc.
CPC分类号： C12N15/115 , G01N33/58
摘要： The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains (UPS), proteins bound by nucleic acid ligands may be labeled with a detectable moiety. The methods and reagents are particularly useful for the detection of protein targets bound to multiplexed arrays of nucleic acid ligands. The present invention also provides novel methods for the multiplexed evaluation of photocrosslinking nucleic acid ligands. The methods allow one simultaneously to: (1) evaluate the performance (dynamic range) of a plurality of photocrosslinking nucleic acid ligands; and (2) assess the specificity of each photocrosslinking nucleic acid ligand for its cognate target protein. Photocrosslinking nucleic acid ligands with the most desirable properties can then be selected for use in diagnostic and prognostic medical assays. The present invention also provides a photocrosslinking nucleic acid ligand that binds specifically to HIV gp120MN.
-
搜索结果
2 条记录 (耗时 0.009 秒)
